BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 36271982)

  • 1. Mechanism studies of the activation of DNA methyltransferase DNMT1 triggered by histone H3 ubiquitination, revealed by multi-scale molecular dynamics simulations.
    Sun J; Liu F; Yuan L; Pang NN; Zhu B; Yang N
    Sci China Life Sci; 2023 Feb; 66(2):313-323. PubMed ID: 36271982
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance.
    Ishiyama S; Nishiyama A; Saeki Y; Moritsugu K; Morimoto D; Yamaguchi L; Arai N; Matsumura R; Kawakami T; Mishima Y; Hojo H; Shimamura S; Ishikawa F; Tajima S; Tanaka K; Ariyoshi M; Shirakawa M; Ikeguchi M; Kidera A; Suetake I; Arita K; Nakanishi M
    Mol Cell; 2017 Oct; 68(2):350-360.e7. PubMed ID: 29053958
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enhanced processivity of Dnmt1 by monoubiquitinated histone H3.
    Mishima Y; Brueckner L; Takahashi S; Kawakami T; Otani J; Shinohara A; Takeshita K; Garvilles RG; Watanabe M; Sakai N; Takeshima H; Nachtegael C; Nishiyama A; Nakanishi M; Arita K; Nakashima K; Hojo H; Suetake I
    Genes Cells; 2020 Jan; 25(1):22-32. PubMed ID: 31680384
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA.
    Berkyurek AC; Suetake I; Arita K; Takeshita K; Nakagawa A; Shirakawa M; Tajima S
    J Biol Chem; 2014 Jan; 289(1):379-86. PubMed ID: 24253042
    [TBL] [Abstract][Full Text] [Related]  

  • 5. RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails.
    Mishima Y; Brueckner L; Takahashi S; Kawakami T; Arita K; Oka S; Otani J; Hojo H; Shirakawa M; Shinohara A; Watanabe M; Suetake I
    FEBS J; 2017 Oct; 284(20):3455-3469. PubMed ID: 28834260
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition.
    Misaki T; Yamaguchi L; Sun J; Orii M; Nishiyama A; Nakanishi M
    Biochem Biophys Res Commun; 2016 Feb; 470(3):741-747. PubMed ID: 26774338
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
    Syeda F; Fagan RL; Wean M; Avvakumov GV; Walker JR; Xue S; Dhe-Paganon S; Brenner C
    J Biol Chem; 2011 Apr; 286(17):15344-51. PubMed ID: 21389349
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
    Tajima S; Suetake I; Takeshita K; Nakagawa A; Kimura H; Song J
    Adv Exp Med Biol; 2022; 1389():45-68. PubMed ID: 36350506
    [TBL] [Abstract][Full Text] [Related]  

  • 9. RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation.
    Wu BK; Mei SC; Brenner C
    Cell Cycle; 2014; 13(20):3222-31. PubMed ID: 25485502
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain.
    Bashtrykov P; Rajavelu A; Hackner B; Ragozin S; Carell T; Jeltsch A
    Chembiochem; 2014 Mar; 15(5):743-8. PubMed ID: 24532244
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural basis for activation of DNMT1.
    Kikuchi A; Onoda H; Yamaguchi K; Kori S; Matsuzawa S; Chiba Y; Tanimoto S; Yoshimi S; Sato H; Yamagata A; Shirouzu M; Adachi N; Sharif J; Koseki H; Nishiyama A; Nakanishi M; Defossez PA; Arita K
    Nat Commun; 2022 Nov; 13(1):7130. PubMed ID: 36414620
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal Structure of Human DNA Methyltransferase 1.
    Zhang ZM; Liu S; Lin K; Luo Y; Perry JJ; Wang Y; Song J
    J Mol Biol; 2015 Jul; 427(15):2520-2531. PubMed ID: 26070743
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Histone H3 Inhibits Ubiquitin-Ubiquitin Intermolecular Interactions to Enhance Binding to DNA Methyl Transferase 1.
    Yasuda T; Morita R; Shigeta Y; Harada R
    J Mol Biol; 2022 Jan; 434(2):167371. PubMed ID: 34838519
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation.
    Garvilles RG; Hasegawa T; Kimura H; Sharif J; Muto M; Koseki H; Takahashi S; Suetake I; Tajima S
    PLoS One; 2015; 10(9):e0137509. PubMed ID: 26383849
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation.
    Li T; Wang L; Du Y; Xie S; Yang X; Lian F; Zhou Z; Qian C
    Nucleic Acids Res; 2018 Apr; 46(6):3218-3231. PubMed ID: 29471350
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions.
    Zhu Y; Ye F; Zhou Z; Liu W; Liang Z; Hu G
    Molecules; 2021 Aug; 26(17):. PubMed ID: 34500587
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Disease-Associated Mutations G589A and V590F Relieve Replication Focus Targeting Sequence-Mediated Autoinhibition of DNA Methyltransferase 1.
    Dolen EK; McGinnis JH; Tavory RN; Weiss JA; Switzer RL
    Biochemistry; 2019 Dec; 58(51):5151-5159. PubMed ID: 31804802
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1).
    Takeshita K; Suetake I; Yamashita E; Suga M; Narita H; Nakagawa A; Tajima S
    Proc Natl Acad Sci U S A; 2011 May; 108(22):9055-9. PubMed ID: 21518897
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism.
    Bashtrykov P; Jankevicius G; Jurkowska RZ; Ragozin S; Jeltsch A
    J Biol Chem; 2014 Feb; 289(7):4106-15. PubMed ID: 24368767
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.
    Song J; Rechkoblit O; Bestor TH; Patel DJ
    Science; 2011 Feb; 331(6020):1036-40. PubMed ID: 21163962
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.