These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

128 related articles for article (PubMed ID: 36273823)

  • 1. Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na
    Asano D; Nakamura K; Nishiya Y; Shiozawa H; Takakusa H; Shibayama T; Inoue SI; Shinozuka T; Hamada T; Yahara C; Watanabe N; Yoshinari K
    Drug Metab Dispos; 2023 Jan; 51(1):67-80. PubMed ID: 36273823
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na
    Asano D; Hamaue S; Zahir H; Shiozawa H; Nishiya Y; Kimura T; Kazui M; Yamamura N; Ikeguchi M; Shibayama T; Inoue SI; Shinozuka T; Watanabe T; Yahara C; Watanabe N; Yoshinari K
    Drug Metab Dispos; 2022 Mar; 50(3):235-242. PubMed ID: 34930785
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evaluation of species differences in the metabolism of the selective Na
    Asano D; Shibayama T; Shiozawa H; Inoue SI; Shinozuka T; Murata S; Watanabe N; Yoshinari K
    Xenobiotica; 2021 Sep; 51(9):1060-1070. PubMed ID: 34330191
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes.
    Sanoh S; Nozaki K; Murai H; Terashita S; Teramura T; Ohta S
    Drug Metab Dispos; 2012 Jan; 40(1):76-82. PubMed ID: 21984595
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.
    Tanoue C; Sugihara K; Uramaru N; Tayama Y; Watanabe Y; Horie T; Ohta S; Kitamura S
    Xenobiotica; 2013 Nov; 43(11):956-62. PubMed ID: 23651075
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver.
    Kato S; Shah A; Plesescu M; Miyata Y; Bolleddula J; Chowdhury S; Zhu X
    Drug Metab Dispos; 2020 Oct; 48(10):934-943. PubMed ID: 32665417
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers.
    Kamimura H; Uehara S; Yoneda N; Suemizu H
    Xenobiotica; 2023 Dec; 53(8-9):523-535. PubMed ID: 37938160
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver.
    Sanoh S; Horiguchi A; Sugihara K; Kotake Y; Tayama Y; Ohshita H; Tateno C; Horie T; Kitamura S; Ohta S
    Drug Metab Dispos; 2012 Feb; 40(2):322-8. PubMed ID: 22048522
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
    Kamimura H; Ito S; Chijiwa H; Okuzono T; Ishiguro T; Yamamoto Y; Nishinoaki S; Ninomiya SI; Mitsui M; Kalgutkar AS; Yamazaki H; Suemizu H
    Xenobiotica; 2017 May; 47(5):382-393. PubMed ID: 27389028
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.
    Uehara S; Yoneda N; Higuchi Y; Yamazaki H; Suemizu H
    Drug Metab Dispos; 2020 Jul; 48(7):580-586. PubMed ID: 32357972
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2.
    Nakada N
    Pharm Res; 2017 Apr; 34(4):874-886. PubMed ID: 28194636
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates.
    Feng B; Pemberton R; Dworakowski W; Ye Z; Zetterberg C; Wang G; Morikawa Y; Kumar S
    Drug Metab Dispos; 2021 Mar; 49(3):254-264. PubMed ID: 33376106
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans.
    Nakada N; Kawamura A; Kamimura H; Sato K; Kazuki Y; Kakuni M; Ohbuchi M; Kato K; Tateno C; Oshimura M; Usui T
    Biopharm Drug Dispos; 2016 Jan; 37(1):3-14. PubMed ID: 26352195
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.
    Sanoh S; Horiguchi A; Sugihara K; Kotake Y; Tayama Y; Uramaru N; Ohshita H; Tateno C; Horie T; Kitamura S; Ohta S
    Drug Metab Dispos; 2012 Dec; 40(12):2267-72. PubMed ID: 22936315
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions.
    Greupink R; Schreurs M; Benne MS; Huisman MT; Russel FG
    Eur J Pharm Sci; 2013 Aug; 49(5):819-28. PubMed ID: 23806476
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.
    Schulz-Utermoehl T; Sarda S; Foster JR; Jacobsen M; Kenna JG; Morikawa Y; Salmu J; Gross G; Wilson ID
    Xenobiotica; 2012 Jun; 42(6):503-17. PubMed ID: 22201515
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver.
    Kato K; Ohbuchi M; Hamamura S; Ohshita H; Kazuki Y; Oshimura M; Sato K; Nakada N; Kawamura A; Usui T; Kamimura H; Tateno C
    Drug Metab Dispos; 2015 Aug; 43(8):1208-17. PubMed ID: 25979261
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Crouch RD; Morrison RD; Byers FW; Lindsley CW; Emmitte KA; Daniels JS
    Drug Metab Dispos; 2016 Aug; 44(8):1296-303. PubMed ID: 26936972
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.
    Samuelsson K; Pickup K; Sarda S; Swales JG; Morikawa Y; Schulz-Utermoehl T; Hutchison M; Wilson ID
    Xenobiotica; 2012 Nov; 42(11):1128-37. PubMed ID: 22642803
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Physiologically based pharmacokinetic modeling of CYP2C8 substrate rosiglitazone and its metabolite to predict metabolic drug-drug interaction.
    Gaud N; Gogola D; Kowal-Chwast A; Gabor-Worwa E; Littlewood P; Brzózka K; Kus K; Walczak M
    Drug Metab Pharmacokinet; 2024 Aug; 57():101023. PubMed ID: 39088906
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.