These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

155 related articles for article (PubMed ID: 36399908)

  • 1. Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation.
    Xu X; Ghatge MS; Huang B; Alghamdi A; Wang H; Pierce BD; Abdulmalik O; Zhang Y; Safo MK; Venitz J
    J Pharm Biomed Anal; 2023 Jan; 223():115152. PubMed ID: 36399908
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.
    Safo MK; Abdulmalik O; Danso-Danquah R; Burnett JC; Nokuri S; Joshi GS; Musayev FN; Asakura T; Abraham DJ
    J Med Chem; 2004 Sep; 47(19):4665-76. PubMed ID: 15341482
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.
    Pagare PP; Ghatge MS; Musayev FN; Deshpande TM; Chen Q; Braxton C; Kim S; Venitz J; Zhang Y; Abdulmalik O; Safo MK
    Bioorg Med Chem; 2018 May; 26(9):2530-2538. PubMed ID: 29655608
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin.
    Enakaya NA; Jefferson A; Chew-Martinez D; Matthews JS
    Acc Chem Res; 2023 Jun; 56(11):1279-1286. PubMed ID: 36946781
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Schiff base adducts of hemoglobin. Modifications that inhibit erythrocyte sickling.
    Zaugg RH; Walder JA; Klotz IM
    J Biol Chem; 1977 Dec; 252(23):8542-8. PubMed ID: 925011
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.
    Xu GG; Pagare PP; Ghatge MS; Safo RP; Gazi A; Chen Q; David T; Alabbas AB; Musayev FN; Venitz J; Zhang Y; Safo MK; Abdulmalik O
    Mol Pharm; 2017 Oct; 14(10):3499-3511. PubMed ID: 28858508
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property.
    Pagare PP; Rastegar A; Abdulmalik O; Omar AM; Zhang Y; Fleischman A; Safo MK
    Expert Opin Ther Pat; 2022 Feb; 32(2):115-130. PubMed ID: 34657559
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin.
    Abdulmalik O; Ghatge MS; Musayev FN; Parikh A; Chen Q; Yang J; Nnamani I; Danso-Danquah R; Eseonu DN; Asakura T; Abraham DJ; Venitz J; Safo MK
    Acta Crystallogr D Biol Crystallogr; 2011 Nov; 67(Pt 11):920-8. PubMed ID: 22101818
    [TBL] [Abstract][Full Text] [Related]  

  • 9. VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions.
    Abdulmalik O; Pagare PP; Huang B; Xu GG; Ghatge MS; Xu X; Chen Q; Anabaraonye N; Musayev FN; Omar AM; Venitz J; Zhang Y; Safo MK
    Sci Rep; 2020 Nov; 10(1):20277. PubMed ID: 33219275
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin.
    Omar AM; Mahran MA; Ghatge MS; Bamane FH; Ahmed MH; El-Araby ME; Abdulmalik O; Safo MK
    Molecules; 2016 Aug; 21(8):. PubMed ID: 27529207
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeted modification of furan-2-carboxaldehydes into Michael acceptor analogs yielded long-acting hemoglobin modulators with dual antisickling activities.
    Omar AM; Abdulmalik O; El-Say KM; Ghatge MS; Cyril-Olutayo M; Paredes S; Al-Awadh M; El-Araby ME; Safo MK
    Chem Biol Drug Des; 2024 Jan; 103(1):e14371. PubMed ID: 37798397
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease.
    Alhashimi RT; Ghatge MS; Donkor AK; Deshpande TM; Anabaraonye N; Alramadhani D; Danso-Danquah R; Huang B; Zhang Y; Musayev FN; Abdulmalik O; Safo MK
    Biomolecules; 2022 May; 12(5):. PubMed ID: 35625623
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents.
    Pagare PP; Ghatge MS; Chen Q; Musayev FN; Venitz J; Abdulmalik O; Zhang Y; Safo MK
    J Med Chem; 2020 Dec; 63(23):14724-14739. PubMed ID: 33205981
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.
    Nakagawa A; Ferrari M; Schleifer G; Cooper MK; Liu C; Yu B; Berra L; Klings ES; Safo RS; Chen Q; Musayev FN; Safo MK; Abdulmalik O; Bloch DB; Zapol WM
    Mol Pharm; 2018 May; 15(5):1954-1963. PubMed ID: 29634905
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice.
    Dufu K; Williams AT; Muller CR; Walser CM; Lucas A; Eaker AM; Alt C; Cathers BE; Oksenberg D; Cabrales P
    Am J Physiol Heart Circ Physiol; 2021 Aug; 321(2):H400-H411. PubMed ID: 34213392
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation.
    Deshpande TM; Pagare PP; Ghatge MS; Chen Q; Musayev FN; Venitz J; Zhang Y; Abdulmalik O; Safo MK
    Acta Crystallogr D Struct Biol; 2018 Oct; 74(Pt 10):956-964. PubMed ID: 30289405
    [TBL] [Abstract][Full Text] [Related]  

  • 17. X-ray crystallography and sickle cell disease drug discovery-a tribute to Donald Abraham.
    Donkor AK; Pagare PP; Mughram MHA; Safo MK
    Front Mol Biosci; 2023; 10():1136970. PubMed ID: 37293554
    [TBL] [Abstract][Full Text] [Related]  

  • 18. How allosteric effectors can bind to the same protein residue and produce opposite shifts in the allosteric equilibrium.
    Abraham DJ; Safo MK; Boyiri T; Danso-Danquah RE; Kister J; Poyart C
    Biochemistry; 1995 Nov; 34(46):15006-20. PubMed ID: 7578114
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde.
    Alhashimi RT; Ahmed TA; Alghanem L; Pagare PP; Huang B; Ghatge MS; Omar AM; Abdulmalik O; Zhang Y; Safo MK
    Pharmaceutics; 2023 Oct; 15(11):. PubMed ID: 38004527
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
    Henry ER; Metaferia B; Li Q; Harper J; Best RB; Glass KE; Cellmer T; Dunkelberger EB; Conrey A; Thein SL; Bunn HF; Eaton WA
    Blood; 2021 Sep; 138(13):1172-1181. PubMed ID: 34197597
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.