149 related articles for article (PubMed ID: 36460141)
1. Transcription-associated cyclin-dependent kinase 12 (CDK12) as a potential target for cancer therapy.
Wu W; Yu S; Yu X
Biochim Biophys Acta Rev Cancer; 2023 Jan; 1878(1):188842. PubMed ID: 36460141
[TBL] [Abstract][Full Text] [Related]
2. CDK12: a potential therapeutic target in cancer.
Emadi F; Teo T; Rahaman MH; Wang S
Drug Discov Today; 2020 Dec; 25(12):2257-2267. PubMed ID: 33038524
[TBL] [Abstract][Full Text] [Related]
3. CDK12: an emerging therapeutic target for cancer.
Lui GYL; Grandori C; Kemp CJ
J Clin Pathol; 2018 Nov; 71(11):957-962. PubMed ID: 30104286
[TBL] [Abstract][Full Text] [Related]
4. Gene expression regulation by CDK12: a versatile kinase in cancer with functions beyond CTD phosphorylation.
Choi SH; Kim S; Jones KA
Exp Mol Med; 2020 May; 52(5):762-771. PubMed ID: 32451425
[TBL] [Abstract][Full Text] [Related]
5. Role and therapeutic potential of CDK12 in human cancers.
Chilà R; Guffanti F; Damia G
Cancer Treat Rev; 2016 Nov; 50():83-88. PubMed ID: 27662623
[TBL] [Abstract][Full Text] [Related]
6.
Liang S; Hu L; Wu Z; Chen Z; Liu S; Xu X; Qian A
Cells; 2020 Jun; 9(6):. PubMed ID: 32570740
[TBL] [Abstract][Full Text] [Related]
7. Th e role of CDK12 in tumor bio logy.
Dzimková M; Procházková J; Klát J; Kohoutek J
Klin Onkol; 2020; 33(4):260-267. PubMed ID: 32894954
[TBL] [Abstract][Full Text] [Related]
8. A patent and literature review of CDK12 inhibitors.
Tang R; Liu J; Li S; Zhang J; Yu C; Liu H; Chen F; Lv L; Zhang Q; Yuan K; Shao H
Expert Opin Ther Pat; 2022 Oct; 32(10):1055-1065. PubMed ID: 36120913
[TBL] [Abstract][Full Text] [Related]
9. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
Dubbury SJ; Boutz PL; Sharp PA
Nature; 2018 Dec; 564(7734):141-145. PubMed ID: 30487607
[TBL] [Abstract][Full Text] [Related]
10. The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation.
Schmitz M; Kaltheuner IH; Anand K; Düster R; Moecking J; Monastyrskyi A; Duckett DR; Roush WR; Geyer M
J Biol Chem; 2024 Jan; 300(1):105501. PubMed ID: 38016516
[TBL] [Abstract][Full Text] [Related]
11. Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery.
Liu H; Liu K; Dong Z
Cancer Res; 2021 Jan; 81(1):18-26. PubMed ID: 32958547
[TBL] [Abstract][Full Text] [Related]
12. Development, validation, and evaluation of a deep learning model to screen cyclin-dependent kinase 12 inhibitors in cancers.
Wen T; Wang J; Lu R; Tan S; Li P; Yao X; Liu H; Yi Z; Li L; Liu S; Gao P; Qian H; Xie G; Ma F
Eur J Med Chem; 2023 Mar; 250():115199. PubMed ID: 36827953
[TBL] [Abstract][Full Text] [Related]
13. The emerging roles of CDK12 in tumorigenesis.
Paculová H; Kohoutek J
Cell Div; 2017; 12():7. PubMed ID: 29090014
[TBL] [Abstract][Full Text] [Related]
14. CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.
Tien JF; Mazloomian A; Cheng SG; Hughes CS; Chow CCT; Canapi LT; Oloumi A; Trigo-Gonzalez G; Bashashati A; Xu J; Chang VC; Shah SP; Aparicio S; Morin GB
Nucleic Acids Res; 2017 Jun; 45(11):6698-6716. PubMed ID: 28334900
[TBL] [Abstract][Full Text] [Related]
15. Current progress and novel strategies that target CDK12 for drug discovery.
Lei P; Zhang J; Liao P; Ren C; Wang J; Wang Y
Eur J Med Chem; 2022 Oct; 240():114603. PubMed ID: 35868123
[TBL] [Abstract][Full Text] [Related]
16. Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy.
Chou J; Quigley DA; Robinson TM; Feng FY; Ashworth A
Cancer Discov; 2020 Mar; 10(3):351-370. PubMed ID: 32071145
[TBL] [Abstract][Full Text] [Related]
17. CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Krajewska M; Dries R; Grassetti AV; Dust S; Gao Y; Huang H; Sharma B; Day DS; Kwiatkowski N; Pomaville M; Dodd O; Chipumuro E; Zhang T; Greenleaf AL; Yuan GC; Gray NS; Young RA; Geyer M; Gerber SA; George RE
Nat Commun; 2019 Apr; 10(1):1757. PubMed ID: 30988284
[TBL] [Abstract][Full Text] [Related]
18. Low expression of CDK12 in gastric cancer is correlated with advanced stage and poor outcome.
Liu M; Fan H; Li T; Sihong L; Qiao S; Bi J
Pathol Res Pract; 2020 Jul; 216(7):152962. PubMed ID: 32534699
[TBL] [Abstract][Full Text] [Related]
19. [Function of CDK12 in Tumor initiation and progression and its clinical consequences].
Vrábel D; Svoboda M; Navrátil J; Kohoutek J
Klin Onkol; 2014; 27(5):340-6. PubMed ID: 25312711
[TBL] [Abstract][Full Text] [Related]
20. MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma.
Pitolli C; Marini A; Guerra M; Pieraccioli M; Marabitti V; Palluzzi F; Giacò L; Tamburrini G; Cecconi F; Nazio F; Sette C; Pagliarini V
J Exp Clin Cancer Res; 2023 Aug; 42(1):214. PubMed ID: 37599362
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
