243 related articles for article (PubMed ID: 36480007)
1. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Popescu AS; Butler CA; Allendorf DH; Piers TM; Mallach A; Roewe J; Reinhardt P; Cinti A; Redaelli L; Boudesco C; Pradier L; Pocock JM; Thornton P; Brown GC
Glia; 2023 Apr; 71(4):974-990. PubMed ID: 36480007
[TBL] [Abstract][Full Text] [Related]
2. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Hall-Roberts H; Agarwal D; Obst J; Smith TB; Monzón-Sandoval J; Di Daniel E; Webber C; James WS; Mead E; Davis JB; Cowley SA
Alzheimers Res Ther; 2020 Nov; 12(1):151. PubMed ID: 33198789
[TBL] [Abstract][Full Text] [Related]
3. Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
Korvatska O; Kiianitsa K; Ratushny A; Matsushita M; Beeman N; Chien WM; Satoh JI; Dorschner MO; Keene CD; Bammler TK; Bird TD; Raskind WH
Front Immunol; 2020; 11():559342. PubMed ID: 33101276
[TBL] [Abstract][Full Text] [Related]
4. Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Cosker K; Mallach A; Limaye J; Piers TM; Staddon J; Neame SJ; Hardy J; Pocock JM
Sci Rep; 2021 Jun; 11(1):13316. PubMed ID: 34172778
[TBL] [Abstract][Full Text] [Related]
5. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Xiang X; Piers TM; Wefers B; Zhu K; Mallach A; Brunner B; Kleinberger G; Song W; Colonna M; Herms J; Wurst W; Pocock JM; Haass C
Mol Neurodegener; 2018 Sep; 13(1):49. PubMed ID: 30185230
[TBL] [Abstract][Full Text] [Related]
6. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss.
Penney J; Ralvenius WT; Loon A; Cerit O; Dileep V; Milo B; Pao PC; Woolf H; Tsai LH
Glia; 2024 Feb; 72(2):452-469. PubMed ID: 37969043
[TBL] [Abstract][Full Text] [Related]
7. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease.
Claes C; Danhash EP; Hasselmann J; Chadarevian JP; Shabestari SK; England WE; Lim TE; Hidalgo JLS; Spitale RC; Davtyan H; Blurton-Jones M
Mol Neurodegener; 2021 Jul; 16(1):50. PubMed ID: 34301296
[TBL] [Abstract][Full Text] [Related]
8. Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Ellwanger DC; Wang S; Brioschi S; Shao Z; Green L; Case R; Yoo D; Weishuhn D; Rathanaswami P; Bradley J; Rao S; Cha D; Luan P; Sambashivan S; Gilfillan S; Hasson SA; Foltz IN; van Lookeren Campagne M; Colonna M
Proc Natl Acad Sci U S A; 2021 Jan; 118(3):. PubMed ID: 33446504
[TBL] [Abstract][Full Text] [Related]
9. SHIP inhibition mediates select TREM2-induced microglial functions.
Ramakrishnan GS; Berry WL; Pacherille A; Kerr WG; Chisholm JD; Pedicone C; Humphrey MB
Mol Immunol; 2024 Jun; 170():35-45. PubMed ID: 38613944
[TBL] [Abstract][Full Text] [Related]
10. A Trem2
Tran KM; Kawauchi S; Kramár EA; Rezaie N; Liang HY; Sakr JS; Gomez-Arboledas A; Arreola MA; Cunha CD; Phan J; Wang S; Collins S; Walker A; Shi KX; Neumann J; Filimban G; Shi Z; Milinkeviciute G; Javonillo DI; Tran K; Gantuz M; Forner S; Swarup V; Tenner AJ; LaFerla FM; Wood MA; Mortazavi A; MacGregor GR; Green KN
Mol Neurodegener; 2023 Feb; 18(1):12. PubMed ID: 36803190
[TBL] [Abstract][Full Text] [Related]
11. AD-linked R47H-
Sayed FA; Kodama L; Fan L; Carling GK; Udeochu JC; Le D; Li Q; Zhou L; Wong MY; Horowitz R; Ye P; Mathys H; Wang M; Niu X; Mazutis L; Jiang X; Wang X; Gao F; Brendel M; Telpoukhovskaia M; Tracy TE; Frost G; Zhou Y; Li Y; Qiu Y; Cheng Z; Yu G; Hardy J; Coppola G; Wang F; DeTure MA; Zhang B; Xie L; Trajnowski JQ; Lee VMY; Gong S; Sinha SC; Dickson DW; Luo W; Gan L
Sci Transl Med; 2021 Dec; 13(622):eabe3947. PubMed ID: 34851693
[TBL] [Abstract][Full Text] [Related]
12. Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge.
Cousins O; Schubert JJ; Chandra A; Veronese M; Valkimadi P; Creese B; Khan Z; Arathimos R; Hampshire A; Rosenzweig I; Ballard C; Corbett A; Aasland D; Velayudhan L; O'Neill M; Collier D; Awais R; Sander K; Årstad E; Howes O; Turkheimer F; Hodges A
J Neuroinflammation; 2023 Nov; 20(1):272. PubMed ID: 37990275
[TBL] [Abstract][Full Text] [Related]
13. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
Piers TM; Cosker K; Mallach A; Johnson GT; Guerreiro R; Hardy J; Pocock JM
FASEB J; 2020 Feb; 34(2):2436-2450. PubMed ID: 31907987
[TBL] [Abstract][Full Text] [Related]
14. Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains.
Ma L; Allen M; Sakae N; Ertekin-Taner N; Graff-Radford NR; Dickson DW; Younkin SG; Sevlever D
Mol Neurodegener; 2016 Nov; 11(1):72. PubMed ID: 27887626
[TBL] [Abstract][Full Text] [Related]
15. Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
Song WM; Joshita S; Zhou Y; Ulland TK; Gilfillan S; Colonna M
J Exp Med; 2018 Mar; 215(3):745-760. PubMed ID: 29321225
[TBL] [Abstract][Full Text] [Related]
16. Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.
Claes C; Van Den Daele J; Boon R; Schouteden S; Colombo A; Monasor LS; Fiers M; Ordovás L; Nami F; Bohrmann B; Tahirovic S; De Strooper B; Verfaillie CM
Alzheimers Dement; 2019 Mar; 15(3):453-464. PubMed ID: 30442540
[TBL] [Abstract][Full Text] [Related]
17. Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer's Risk Variant.
Tambini MD; D'Adamio L
Sci Rep; 2020 Mar; 10(1):4122. PubMed ID: 32139718
[TBL] [Abstract][Full Text] [Related]
18. TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology.
Fracassi A; Marcatti M; Tumurbaatar B; Woltjer R; Moreno S; Taglialatela G
Brain Pathol; 2023 Jan; 33(1):e13108. PubMed ID: 35816404
[TBL] [Abstract][Full Text] [Related]
19. Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology.
Wood JI; Wong E; Joghee R; Balbaa A; Vitanova KS; Stringer KM; Vanshoiack A; Phelan SJ; Launchbury F; Desai S; Tripathi T; Hanrieder J; Cummings DM; Hardy J; Edwards FA
Cell Rep; 2022 Nov; 41(8):111686. PubMed ID: 36417868
[TBL] [Abstract][Full Text] [Related]
20. Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Sudom A; Talreja S; Danao J; Bragg E; Kegel R; Min X; Richardson J; Zhang Z; Sharkov N; Marcora E; Thibault S; Bradley J; Wood S; Lim AC; Chen H; Wang S; Foltz IN; Sambashivan S; Wang Z
J Biol Chem; 2018 Aug; 293(32):12634-12646. PubMed ID: 29794134
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
