194 related articles for article (PubMed ID: 36508676)
1. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
[TBL] [Abstract][Full Text] [Related]
2. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
Chan EM; Foster KJ; Bass AJ
Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
[TBL] [Abstract][Full Text] [Related]
3. WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency.
Sobol RW
Proc Natl Acad Sci U S A; 2023 Jan; 120(2):e2219963120. PubMed ID: 36598947
[No Abstract] [Full Text] [Related]
4. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
[TBL] [Abstract][Full Text] [Related]
5. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
Elife; 2019 Mar; 8():. PubMed ID: 30910006
[TBL] [Abstract][Full Text] [Related]
6. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
[TBL] [Abstract][Full Text] [Related]
7. WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Kawasaki T; Ohnishi M; Suemoto Y; Kirkner GJ; Liu Z; Yamamoto H; Loda M; Fuchs CS; Ogino S
Mod Pathol; 2008 Feb; 21(2):150-8. PubMed ID: 18084250
[TBL] [Abstract][Full Text] [Related]
8. The WRN helicase: resolving a new target in microsatellite unstable cancers.
van Wietmarschen N; Nathan WJ; Nussenzweig A
Curr Opin Genet Dev; 2021 Dec; 71():34-38. PubMed ID: 34284257
[TBL] [Abstract][Full Text] [Related]
9. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
[TBL] [Abstract][Full Text] [Related]
10. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
[TBL] [Abstract][Full Text] [Related]
11. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
Kategaya L; Perumal SK; Hager JH; Belmont LD
iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619
[TBL] [Abstract][Full Text] [Related]
12. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011
[TBL] [Abstract][Full Text] [Related]
13. p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
Sommers JA; Sharma S; Doherty KM; Karmakar P; Yang Q; Kenny MK; Harris CC; Brosh RM
Cancer Res; 2005 Feb; 65(4):1223-33. PubMed ID: 15735006
[TBL] [Abstract][Full Text] [Related]
14. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA
Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936
[TBL] [Abstract][Full Text] [Related]
15. p53-mediated apoptosis is attenuated in Werner syndrome cells.
Spillare EA; Robles AI; Wang XW; Shen JC; Yu CE; Schellenberg GD; Harris CC
Genes Dev; 1999 Jun; 13(11):1355-60. PubMed ID: 10364153
[TBL] [Abstract][Full Text] [Related]
16. Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.
Ren X; Lim S; Ji Z; Yuh J; Peng V; Smith MT; Zhang L
PLoS One; 2011 Jan; 6(1):e14546. PubMed ID: 21267443
[TBL] [Abstract][Full Text] [Related]
17. The Werner syndrome protein contributes to induction of p53 by DNA damage.
Blander G; Zalle N; Leal JF; Bar-Or RL; Yu CE; Oren M
FASEB J; 2000 Nov; 14(14):2138-40. PubMed ID: 11023999
[TBL] [Abstract][Full Text] [Related]
18. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
van Wietmarschen N; Sridharan S; Nathan WJ; Tubbs A; Chan EM; Callen E; Wu W; Belinky F; Tripathi V; Wong N; Foster K; Noorbakhsh J; Garimella K; Cruz-Migoni A; Sommers JA; Huang Y; Borah AA; Smith JT; Kalfon J; Kesten N; Fugger K; Walker RL; Dolzhenko E; Eberle MA; Hayward BE; Usdin K; Freudenreich CH; Brosh RM; West SC; McHugh PJ; Meltzer PS; Bass AJ; Nussenzweig A
Nature; 2020 Oct; 586(7828):292-298. PubMed ID: 32999459
[TBL] [Abstract][Full Text] [Related]
19. Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Newman JA; Gavard AE; Lieb S; Ravichandran MC; Hauer K; Werni P; Geist L; Böttcher J; Engen JR; Rumpel K; Samwer M; Petronczki M; Gileadi O
Life Sci Alliance; 2021 Jan; 4(1):. PubMed ID: 33199508
[TBL] [Abstract][Full Text] [Related]
20. The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
Shen JC; Loeb LA
Trends Genet; 2000 May; 16(5):213-20. PubMed ID: 10782115
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
