Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 36508676)

  • 1. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
    Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
    Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
    Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
    Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
    [TBL] [Abstract][Full Text] [Related]  

  • 3. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
    Chan EM; Foster KJ; Bass AJ
    Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
    [TBL] [Abstract][Full Text] [Related]  

  • 4. WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency.
    Sobol RW
    Proc Natl Acad Sci U S A; 2023 Jan; 120(2):e2219963120. PubMed ID: 36598947
    [No Abstract]   [Full Text] [Related]  

  • 5. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
    Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
    Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
    Elife; 2019 Mar; 8():. PubMed ID: 30910006
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
    Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
    Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
    [TBL] [Abstract][Full Text] [Related]  

  • 8. WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.
    Kawasaki T; Ohnishi M; Suemoto Y; Kirkner GJ; Liu Z; Yamamoto H; Loda M; Fuchs CS; Ogino S
    Mod Pathol; 2008 Feb; 21(2):150-8. PubMed ID: 18084250
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The WRN helicase: resolving a new target in microsatellite unstable cancers.
    van Wietmarschen N; Nathan WJ; Nussenzweig A
    Curr Opin Genet Dev; 2021 Dec; 71():34-38. PubMed ID: 34284257
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
    Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
    Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
    [TBL] [Abstract][Full Text] [Related]  

  • 11. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
    Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
    EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
    Kategaya L; Perumal SK; Hager JH; Belmont LD
    iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
    Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
    Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011
    [TBL] [Abstract][Full Text] [Related]  

  • 14. p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
    Sommers JA; Sharma S; Doherty KM; Karmakar P; Yang Q; Kenny MK; Harris CC; Brosh RM
    Cancer Res; 2005 Feb; 65(4):1223-33. PubMed ID: 15735006
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
    Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA
    Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936
    [TBL] [Abstract][Full Text] [Related]  

  • 16. p53-mediated apoptosis is attenuated in Werner syndrome cells.
    Spillare EA; Robles AI; Wang XW; Shen JC; Yu CE; Schellenberg GD; Harris CC
    Genes Dev; 1999 Jun; 13(11):1355-60. PubMed ID: 10364153
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.
    Ren X; Lim S; Ji Z; Yuh J; Peng V; Smith MT; Zhang L
    PLoS One; 2011 Jan; 6(1):e14546. PubMed ID: 21267443
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Werner syndrome protein contributes to induction of p53 by DNA damage.
    Blander G; Zalle N; Leal JF; Bar-Or RL; Yu CE; Oren M
    FASEB J; 2000 Nov; 14(14):2138-40. PubMed ID: 11023999
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
    van Wietmarschen N; Sridharan S; Nathan WJ; Tubbs A; Chan EM; Callen E; Wu W; Belinky F; Tripathi V; Wong N; Foster K; Noorbakhsh J; Garimella K; Cruz-Migoni A; Sommers JA; Huang Y; Borah AA; Smith JT; Kalfon J; Kesten N; Fugger K; Walker RL; Dolzhenko E; Eberle MA; Hayward BE; Usdin K; Freudenreich CH; Brosh RM; West SC; McHugh PJ; Meltzer PS; Bass AJ; Nussenzweig A
    Nature; 2020 Oct; 586(7828):292-298. PubMed ID: 32999459
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Werner helicase mediates the senescence and cell cycle of leukemia cells by regulating DNA repair pathways.
    Cui X; Hou J; Wang S; Yu J; Cheng S; Yu L; Song FJ; Luo H
    Int J Biol Macromol; 2024 Jan; 255():128305. PubMed ID: 37992942
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.