These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 36508676)

  • 21. Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
    Newman JA; Gavard AE; Lieb S; Ravichandran MC; Hauer K; Werni P; Geist L; Böttcher J; Engen JR; Rumpel K; Samwer M; Petronczki M; Gileadi O
    Life Sci Alliance; 2021 Jan; 4(1):. PubMed ID: 33199508
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Challenges for the Discovery of Non-Covalent WRN Helicase Inhibitors.
    Heuser A; Abdul Rahman W; Bechter E; Blank J; Buhr S; Erdmann D; Fontana P; Mermet-Meillon F; Meyerhofer M; Strang R; Schrapp M; Zimmermann C; Cortes-Cros M; Möbitz H; Hamon J
    ChemMedChem; 2024 Apr; 19(8):e202300613. PubMed ID: 38334957
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
    Shen JC; Loeb LA
    Trends Genet; 2000 May; 16(5):213-20. PubMed ID: 10782115
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
    Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
    Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Role for the Werner syndrome protein in the promotion of tumor cell growth.
    Opresko PL; Calvo JP; von Kobbe C
    Mech Ageing Dev; 2007; 128(7-8):423-36. PubMed ID: 17624410
    [TBL] [Abstract][Full Text] [Related]  

  • 26. WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3.
    Aggarwal M; Brosh RM
    Aging (Albany NY); 2009 Feb; 1(2):219-33. PubMed ID: 20157511
    [TBL] [Abstract][Full Text] [Related]  

  • 27. WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.
    Chen L; Huang S; Lee L; Davalos A; Schiestl RH; Campisi J; Oshima J
    Aging Cell; 2003 Aug; 2(4):191-9. PubMed ID: 12934712
    [TBL] [Abstract][Full Text] [Related]  

  • 28.
    Zimmer K; Puccini A; Xiu J; Baca Y; Spizzo G; Lenz HJ; Battaglin F; Goldberg RM; Grothey A; Shields AF; Salem ME; Marshall JL; Korn WM; Wolf D; Kocher F; Seeber A
    Cancers (Basel); 2020 May; 12(5):. PubMed ID: 32455893
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.
    Lazzari L; Corti G; Picco G; Isella C; Montone M; Arcella P; Durinikova E; Zanella ER; Novara L; Barbosa F; Cassingena A; Cancelliere C; Medico E; Sartore-Bianchi A; Siena S; Garnett MJ; Bertotti A; Trusolino L; Di Nicolantonio F; Linnebacher M; Bardelli A; Arena S
    Clin Cancer Res; 2019 Oct; 25(20):6243-6259. PubMed ID: 31375513
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
    Aggarwal M; Sommers JA; Shoemaker RH; Brosh RM
    Proc Natl Acad Sci U S A; 2011 Jan; 108(4):1525-30. PubMed ID: 21220316
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer.
    Gupta P; Majumdar AG; Patro BS
    Aging Cell; 2022 Jun; 21(6):e13625. PubMed ID: 35582959
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
    Agrelo R; Cheng WH; Setien F; Ropero S; Espada J; Fraga MF; Herranz M; Paz MF; Sanchez-Cespedes M; Artiga MJ; Guerrero D; Castells A; von Kobbe C; Bohr VA; Esteller M
    Proc Natl Acad Sci U S A; 2006 Jun; 103(23):8822-7. PubMed ID: 16723399
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Riok1, A Novel Potential Target in MSI-High p53 Mutant Colorectal Cancer Cells.
    Shechter S; Ya'ar Bar S; Khattib H; Gage MJ; Avni D
    Molecules; 2023 May; 28(11):. PubMed ID: 37298928
    [TBL] [Abstract][Full Text] [Related]  

  • 34. p53 Modulates the exonuclease activity of Werner syndrome protein.
    Brosh RM; Karmakar P; Sommers JA; Yang Q; Wang XW; Spillare EA; Harris CC; Bohr VA
    J Biol Chem; 2001 Sep; 276(37):35093-102. PubMed ID: 11427532
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Werner helicase is required for proliferation and DNA damage repair in multiple myeloma.
    Akcora-Yildiz D; Ozkan T; Ozen M; Gunduz M; Sunguroglu A; Beksac M
    Mol Biol Rep; 2023 Feb; 50(2):1565-1573. PubMed ID: 36515823
    [TBL] [Abstract][Full Text] [Related]  

  • 36. WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis.
    Rodríguez Pérez F; Natwick D; Schiff L; McSwiggen D; Heckert A; Huey M; Morrison H; Loo M; Miranda RG; Filbin J; Ortega J; Van Buren K; Murnock D; Tao A; Butler R; Cheng K; Tarvestad W; Zhang Z; Gonzalez E; Miller RM; Kelly M; Tang Y; Ho J; Anderson D; Bashore C; Basham S
    Nat Commun; 2024 Jul; 15(1):6059. PubMed ID: 39025847
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.
    Frank B; Hoffmeister M; Klopp N; Illig T; Chang-Claude J; Brenner H
    Carcinogenesis; 2010 Mar; 31(3):442-5. PubMed ID: 19945966
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV light.
    Guay D; Gaudreault I; Massip L; Lebel M
    Int J Biochem Cell Biol; 2006; 38(8):1300-13. PubMed ID: 16584908
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.
    Galván N; Lim S; Zmugg S; Smith MT; Zhang L
    Mutat Res; 2008 Jan; 649(1-2):54-61. PubMed ID: 17875398
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.
    Machwe A; Lozada EM; Xiao L; Orren DK
    BMC Mol Biol; 2006 Jan; 7():1. PubMed ID: 16412221
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.