BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 36538511)

  • 1. Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer.
    Sun N; Kabir M; Lee Y; Xie L; Hu X; Velez J; Chen X; Kaniskan HÜ; Jin J
    J Med Chem; 2023 Jan; 66(1):596-610. PubMed ID: 36538511
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer.
    Yu X; Li D; Kottur J; Kim HS; Herring LE; Yu Y; Xie L; Hu X; Chen X; Cai L; Liu J; Aggarwal AK; Wang GG; Jin J
    J Med Chem; 2023 Dec; 66(23):16168-16186. PubMed ID: 38019706
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.
    Ždralević M; Brand A; Di Ianni L; Dettmer K; Reinders J; Singer K; Peter K; Schnell A; Bruss C; Decking SM; Koehl G; Felipe-Abrio B; Durivault J; Bayer P; Evangelista M; O'Brien T; Oefner PJ; Renner K; Pouysségur J; Kreutz M
    J Biol Chem; 2018 Oct; 293(41):15947-15961. PubMed ID: 30158244
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.
    Han X; Zhao L; Xiang W; Miao B; Qin C; Wang M; Xu T; McEachern D; Lu J; Wang Y; Metwally H; Yang CY; Kirchhoff PD; Wang L; Matvekas A; Takyi-Williams J; Wen B; Sun D; Ator M; Mckean R; Wang S
    J Med Chem; 2023 Jul; 66(13):8822-8843. PubMed ID: 37382562
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival.
    Mack N; Mazzio EA; Bauer D; Flores-Rozas H; Soliman KF
    Anticancer Res; 2017 Mar; 37(3):1205-1212. PubMed ID: 28314283
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of the First Potent, Selective, and
    Sun Y; Xue Y; Sun P; Mu S; Liu H; Sun Y; Wang L; Wang J; Wu T; Yin W; Qin Q; Sun Y; Liu N; Wang H; Yang H; Zhao D; Cheng M
    J Med Chem; 2023 Jun; 66(12):8200-8221. PubMed ID: 37279162
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of LHF418 as a new potent SOS1 PROTAC degrader.
    Li H; Chai M; Chen Y; Zhou F; Ren X; Xu J; Wang J; Wang Z; Huang W
    Bioorg Med Chem; 2024 Apr; 103():117661. PubMed ID: 38489998
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of the first highly selective inhibitor of human lactate dehydrogenase B.
    Shibata S; Sogabe S; Miwa M; Fujimoto T; Takakura N; Naotsuka A; Kitamura S; Kawamoto T; Soga T
    Sci Rep; 2021 Nov; 11(1):21353. PubMed ID: 34725423
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Therapeutic Strategies Toward Lactate Dehydrogenase Within the Tumor Microenvironment of Pancreatic Cancer.
    Moir JAG; Long A; Haugk B; French JJ; Charnley RM; Manas DM; Wedge SR; Mann J; Robinson SM; White SA
    Pancreas; 2020; 49(10):1364-1371. PubMed ID: 33122526
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
    Christov PP; Kim K; Jana S; Romaine IM; Rai G; Mott BT; Allweil AA; Lamers A; Brimacombe KR; Urban DJ; Lee TD; Hu X; Lukacs CM; Davies DR; Jadhav A; Hall MD; Green N; Moore WJ; Stott GM; Flint AJ; Maloney DJ; Sulikowski GA; Waterson AG
    Bioorg Med Chem Lett; 2021 Jun; 41():127974. PubMed ID: 33771585
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment.
    Mishra D; Banerjee D
    Cancers (Basel); 2019 May; 11(6):. PubMed ID: 31146503
    [TBL] [Abstract][Full Text] [Related]  

  • 12. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression.
    Cui J; Shi M; Xie D; Wei D; Jia Z; Zheng S; Gao Y; Huang S; Xie K
    Clin Cancer Res; 2014 May; 20(10):2595-606. PubMed ID: 24634381
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos.
    Meng F; Xu C; Park KS; Kaniskan HÜ; Wang GG; Jin J
    J Med Chem; 2022 Aug; 65(15):10611-10625. PubMed ID: 35895319
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The novel role of LDHA/LDHB in the prognostic value and tumor-immune infiltration in clear cell renal cell carcinoma.
    Chen J; Wu F; Cao Y; Xing Y; Liu Q; Zhao Z
    PeerJ; 2023; 11():e15749. PubMed ID: 37547725
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13.
    Yang J; Chang Y; Tien JC; Wang Z; Zhou Y; Zhang P; Huang W; Vo J; Apel IJ; Wang C; Zeng VZ; Cheng Y; Li S; Wang GX; Chinnaiyan AM; Ding K
    J Med Chem; 2022 Aug; 65(16):11066-11083. PubMed ID: 35938508
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells.
    Urbańska K; Orzechowski A
    Int J Mol Sci; 2019 Apr; 20(9):. PubMed ID: 31035592
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome.
    Mohammad GH; Olde Damink SW; Malago M; Dhar DK; Pereira SP
    PLoS One; 2016; 11(3):e0151635. PubMed ID: 26989901
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation.
    Chen X; Liu L; Kang S; Gnanaprakasam JR; Wang R
    Sci Adv; 2023 Mar; 9(12):eadd9554. PubMed ID: 36961904
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy.
    Sada N; Suto S; Suzuki M; Usui S; Inoue T
    Epilepsia; 2020 May; 61(5):e37-e42. PubMed ID: 32202309
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chemical degrader enhances the treatment of androgen receptor-positive triple-negative breast cancer.
    Wu Y; Xue J; Li J
    Arch Biochem Biophys; 2022 May; 721():109194. PubMed ID: 35337811
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.