These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 36572169)

  • 1. The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models.
    Proença S; van Sabben N; Legler J; Kamstra JH; Kramer NI
    Toxicology; 2023 Feb; 485():153411. PubMed ID: 36572169
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.
    Roques BB; Leghait J; Lacroix MZ; Lasserre F; Pineau T; Viguié C; Martin PG
    Biochem Pharmacol; 2013 Oct; 86(7):997-1039. PubMed ID: 23962444
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays.
    Murase W; Kubota A; Ikeda-Araki A; Terasaki M; Nakagawa K; Shizu R; Yoshinari K; Kojima H
    Toxicology; 2023 Aug; 494():153577. PubMed ID: 37302725
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.
    Hendriks DFG; Vorrink SU; Smutny T; Sim SC; Nordling Å; Ullah S; Kumondai M; Jones BC; Johansson I; Andersson TB; Lauschke VM; Ingelman-Sundberg M
    Clin Pharmacol Ther; 2020 Oct; 108(4):844-855. PubMed ID: 32320483
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
    Haines C; Chatham LR; Vardy A; Elcombe CR; Foster JR; Lake BG
    Toxicology; 2018 May; 400-401():20-27. PubMed ID: 29548889
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.
    Kandel BA; Thomas M; Winter S; Damm G; Seehofer D; Burk O; Schwab M; Zanger UM
    Biochim Biophys Acta; 2016 Sep; 1859(9):1218-1227. PubMed ID: 26994748
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors.
    Rouquié D; Tinwell H; Blanck O; Schorsch F; Geter D; Wason S; Bars R
    Regul Toxicol Pharmacol; 2014 Dec; 70(3):673-80. PubMed ID: 25455223
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A microfluidic thyroid-liver platform to assess chemical safety in humans.
    Kühnlenz J; Karwelat D; Steger-Hartmann T; Raschke M; Bauer S; Vural Ö; Marx U; Tinwell H; Bars R
    ALTEX; 2023; 40(1):61-82. PubMed ID: 35536601
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells.
    van der Mark VA; Adam AAA; Chang JC; Oude Elferink RP; Chamuleau RAFM; Hoekstra R
    Toxicol Appl Pharmacol; 2020 Jul; 399():115055. PubMed ID: 32428594
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.
    Paul KB; Thompson JT; Simmons SO; Vanden Heuvel JP; Crofton KM
    Toxicol In Vitro; 2013 Oct; 27(7):2049-60. PubMed ID: 23899473
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG Cells.
    Tanner N; Kubik L; Luckert C; Thomas M; Hofmann U; Zanger UM; Böhmert L; Lampen A; Braeuning A
    Drug Metab Dispos; 2018 Apr; 46(4):326-335. PubMed ID: 29330220
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Increased hepatic functionality of the human hepatoma cell line HepaRG cultured in the AMC bioreactor.
    Nibourg GA; Hoekstra R; van der Hoeven TV; Ackermans MT; Hakvoort TB; van Gulik TM; Chamuleau RA
    Int J Biochem Cell Biol; 2013 Aug; 45(8):1860-8. PubMed ID: 23770120
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
    Preiss LC; Liu R; Hewitt P; Thompson D; Georgi K; Badolo L; Lauschke VM; Petersson C
    Drug Metab Dispos; 2021 Aug; 49(8):668-678. PubMed ID: 34035124
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.
    Li D; Mackowiak B; Brayman TG; Mitchell M; Zhang L; Huang SM; Wang H
    Biochem Pharmacol; 2015 Nov; 98(1):190-202. PubMed ID: 26275810
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.
    Sueyoshi T; Li L; Wang H; Moore R; Kodavanti PR; Lehmler HJ; Negishi M; Birnbaum LS
    Toxicol Sci; 2014 Feb; 137(2):292-302. PubMed ID: 24218150
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital.
    Schraplau A; Schewe B; Neuschäfer-Rube F; Ringel S; Neuber C; Kleuser B; Püschel GP
    Toxicology; 2015 Feb; 328():21-8. PubMed ID: 25489928
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells.
    van der Mark VA; Rudi de Waart D; Shevchenko V; Elferink RP; Chamuleau RA; Hoekstra R
    Drug Metab Dispos; 2017 Jan; 45(1):56-67. PubMed ID: 27780834
    [TBL] [Abstract][Full Text] [Related]  

  • 18. HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.
    Lübberstedt M; Müller-Vieira U; Mayer M; Biemel KM; Knöspel F; Knobeloch D; Nüssler AK; Gerlach JC; Zeilinger K
    J Pharmacol Toxicol Methods; 2011; 63(1):59-68. PubMed ID: 20460162
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
    Chang HY; Chen CJ; Ma WC; Cheng WK; Lin YN; Lee YR; Chen JJ; Lim YP
    Phytomedicine; 2017 Dec; 36():37-49. PubMed ID: 29157826
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.
    Thomas M; Bayha C; Vetter S; Hofmann U; Schwarz M; Zanger UM; Braeuning A
    Mol Pharmacol; 2015 Jun; 87(6):1013-20. PubMed ID: 25824487
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.