65 related articles for article (PubMed ID: 36577036)
1. Physachenolide C is a Potent, Selective BET Inhibitor.
Zerio CJ; Sivinski J; Wijeratne EMK; Xu YM; Ngo DT; Ambrose AJ; Villa-Celis L; Ghadirian N; Clarkson MW; Zhang DD; Horton NC; Gunatilaka AAL; Fromme R; Chapman E
J Med Chem; 2023 Jan; 66(1):913-933. PubMed ID: 36577036
[TBL] [Abstract][Full Text] [Related]
2. Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets.
Situ Y; Liang Q; Zeng Z; Chen J; Shao Z; Xu Q; Lu X; Cui Y; Zhang J; Lu L; Deng L
Front Endocrinol (Lausanne); 2023; 14():1089531. PubMed ID: 36793283
[TBL] [Abstract][Full Text] [Related]
3. Discovery of a Bromodomain and Extra Terminal Domain (BET) Inhibitor with the Selectivity for the Second Bromodomain (BD2) and the Capacity for the Treatment of Inflammatory Diseases.
Wang Z; Yin L; Xiong Z; Huang F; Yang N; Jiang F; Li H; Cui Y; Ren J; Cheng Z; Jia K; Lu T; Zhu J; Hu Q; Chen Y
J Med Chem; 2023 Aug; 66(15):10824-10848. PubMed ID: 37478496
[TBL] [Abstract][Full Text] [Related]
4. Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe.
Bradley E; Fusani L; Chung CW; Craggs PD; Demont EH; Humphreys PG; Mitchell DJ; Phillipou A; Rioja I; Shah RR; Wellaway CR; Prinjha RK; Palmer DS; Kerr WJ; Reid M; Wall ID; Cookson R
J Med Chem; 2023 Dec; 66(23):15728-15749. PubMed ID: 37967462
[TBL] [Abstract][Full Text] [Related]
5. DW71177: A novel [1,2,4]triazolo[4,3-a]quinoxaline-based potent and BD1-Selective BET inhibitor for the treatment of acute myeloid leukemia.
Ali I; Cha HJ; Lim B; Chae CH; Youm J; Park WJ; Lee SH; Kim JH; Jeong D; Lim JK; Hwang YH; Roe JS; Woo JS; Lee K; Choi G
Eur J Med Chem; 2024 Feb; 265():116052. PubMed ID: 38134745
[TBL] [Abstract][Full Text] [Related]
6. Selectivity Mechanism of Pyrrolopyridone Analogues Targeting Bromodomain 2 of Bromodomain-Containing Protein 4 from Molecular Dynamics Simulations.
Shi M; Zheng X; Zhou Y; Yin Y; Lu Z; Zou Z; Hu Y; Liang Y; Chen T; Yang Y; Jing M; Lei D; Yang P; Li X
ACS Omega; 2023 Sep; 8(37):33658-33674. PubMed ID: 37744850
[TBL] [Abstract][Full Text] [Related]
7. Overexpression of Bromodomain and Extraterminal Domain is Associated with Progression, Metastasis and Unfavorable Outcomes: Highlighting Prognostic and Therapeutic Value of the BET Protein Family in Gastric Cancer.
Fard SS; Kouchaki S; Salimian Z; Sotoudeh M; Mousavi SA; Alimoghaddam K; Ghaffari SH
Anticancer Agents Med Chem; 2023; 23(7):794-806. PubMed ID: 36284375
[TBL] [Abstract][Full Text] [Related]
8. Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.
Yan Z; Lyu X; Lin D; Wu G; Gong Y; Ren X; Xiao J; Lou J; Huang H; Chen Y; Zhao Y
Eur J Med Chem; 2023 Jun; 254():115381. PubMed ID: 37084596
[TBL] [Abstract][Full Text] [Related]
9. Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
Jiang W; Hou Q; Xu H; Yang K; Wang X; Zhang K; Zeng Y; Li W; Wang B; Luo G; Zhao X; Shen H; Xu Y; Wu X
J Med Chem; 2024 Jan; 67(2):1513-1532. PubMed ID: 38175809
[TBL] [Abstract][Full Text] [Related]
10. Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis.
Chen X; Wu T; Du Z; Kang W; Xu R; Meng F; Liu C; Chen Y; Bao Q; Shen J; You Q; Cao D; Jiang Z; Guo X
Eur J Med Chem; 2024 Feb; 265():116080. PubMed ID: 38142510
[TBL] [Abstract][Full Text] [Related]
11. Domain-Selective BET Ligands Yield Next-Generation Synthetic Genome Readers/Regulators with Nonidentical Cellular Functions.
Mohammed A; Waddell MB; Sutkeviciute I; Danda A; Philips SJ; Lang W; Slavish PJ; Kietlinska SJ; Kaulage M; Sourav D; Ansari AZ
J Am Chem Soc; 2023 Nov; ():. PubMed ID: 37923569
[TBL] [Abstract][Full Text] [Related]
12. Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity.
Hu J; Hu B; Xu F; Wang M; Qin C; McEachern D; Stuckey J; Wang S
J Med Chem; 2023 Jun; 66(12):8222-8237. PubMed ID: 37289649
[TBL] [Abstract][Full Text] [Related]
13. Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Franck C; Patel K; Walport LJ; Christie M; Norman A; Passioura T; Suga H; Payne RJ; Mackay JP
Structure; 2023 Aug; 31(8):912-923.e4. PubMed ID: 37269828
[TBL] [Abstract][Full Text] [Related]
14. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.
Divakaran A; Scholtz CR; Zahid H; Lin W; Griffith EC; Lee RE; Chen T; Harki DA; Pomerantz WCK
ACS Med Chem Lett; 2022 Oct; 13(10):1621-1627. PubMed ID: 36262390
[TBL] [Abstract][Full Text] [Related]
15. From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Koravovic M; Mayasundari A; Tasic G; Keramatnia F; Stachowski TR; Cui H; Chai SC; Jonchere B; Yang L; Li Y; Fu X; Hiltenbrand R; Paul L; Mishra V; Klco JM; Roussel MF; Pomerantz WC; Fischer M; Rankovic Z; Savic V
Eur J Med Chem; 2023 May; 251():115246. PubMed ID: 36898329
[TBL] [Abstract][Full Text] [Related]
16. Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family.
Arole AH; Deshmukh P; Sridhar A; Mathur S; Mahalingaswamy M; Subramanya H; Dalavaikodihalli Nanjaiah N; Padmanabhan B
Acta Crystallogr D Struct Biol; 2023 Aug; 79(Pt 8):758-774. PubMed ID: 37432115
[TBL] [Abstract][Full Text] [Related]
17. BET proteins: Biological functions and therapeutic interventions.
Guo J; Zheng Q; Peng Y
Pharmacol Ther; 2023 Mar; 243():108354. PubMed ID: 36739915
[TBL] [Abstract][Full Text] [Related]
18. Discovery and anti-tumor activity of 4-(benzylamino)-6-(3,5-dimethylisoxazol-4-yl)quinolin-2(1H)-one (CG13250), a potent, selective and orally bioavailable BET bromodomain inhibitor.
Chauhan J; Yoshioka M; Pogash S; Strovel JW; Fletcher S
Bioorg Med Chem Lett; 2023 Apr; 86():129220. PubMed ID: 36905966
[TBL] [Abstract][Full Text] [Related]
19. Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease.
Xie Y; Pan Y; Chen Q; Chen Y; Chen G; Wang M; Zeng P; Li Z; Li Z; Wang S; Yang H; Liang D
Invest Ophthalmol Vis Sci; 2023 Jun; 64(7):9. PubMed ID: 37272763
[TBL] [Abstract][Full Text] [Related]
20. 1,4-Dihydropyridinebutyrolactone-derived ring-opened ester and amide analogs targeting BET bromodomains.
Jiang J; Zhao PL; Sigua LH; Chan A; Schönbrunn E; Qi J; Georg GI
Arch Pharm (Weinheim); 2022 Nov; 355(11):e2200288. PubMed ID: 35941525
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
