These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Filling in the Gaps in Metformin Biodegradation: a New Enzyme and a Metabolic Pathway for Guanylurea. Tassoulas LJ; Robinson A; Martinez-Vaz B; Aukema KG; Wackett LP Appl Environ Microbiol; 2021 May; 87(11):. PubMed ID: 33741630 [TBL] [Abstract][Full Text] [Related]
3. Aerobic Degradation of the Antidiabetic Drug Metformin by Li T; Xu ZJ; Zhou NY Environ Sci Technol; 2023 Jan; ():. PubMed ID: 36624085 [TBL] [Abstract][Full Text] [Related]
4. Co-occurrence, toxicity, and biotransformation pathways of metformin and its intermediate product guanylurea: Current state and future prospects for enhanced biodegradation strategy. Dong L; Li S; Huang J; Li WJ; Ali M Sci Total Environ; 2024 Apr; 921():171108. PubMed ID: 38395159 [TBL] [Abstract][Full Text] [Related]
5. Metformin hydrolase is a recently evolved nickel-dependent heteromeric ureohydrolase. Sinn M; Riede L; Fleming JR; Funck D; Lutz H; Bachmann A; Mayans O; Hartig JS Nat Commun; 2024 Sep; 15(1):8045. PubMed ID: 39271653 [TBL] [Abstract][Full Text] [Related]
6. Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives. Elizalde-Velázquez GA; Gómez-Oliván LM Sci Total Environ; 2020 Feb; 702():134924. PubMed ID: 31726346 [TBL] [Abstract][Full Text] [Related]
7. Biodegradation of metformin and its transformation product, guanylurea, by natural and exposed microbial communities. Poursat BAJ; van Spanning RJM; Braster M; Helmus R; de Voogt P; Parsons JR Ecotoxicol Environ Saf; 2019 Oct; 182():109414. PubMed ID: 31301597 [TBL] [Abstract][Full Text] [Related]
8. Occurrence, Impact, Analysis and Treatment of Metformin and Guanylurea in Coastal Aquatic Environments of Canada, USA and Europe. Tao Y; Chen B; Zhang BH; Zhu ZJ; Cai Q Adv Mar Biol; 2018; 81():23-58. PubMed ID: 30471658 [TBL] [Abstract][Full Text] [Related]
9. Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. Tassoulas LJ; Rankin JA; Elias MH; Wackett LP Proc Natl Acad Sci U S A; 2024 Mar; 121(10):e2312652121. PubMed ID: 38408229 [TBL] [Abstract][Full Text] [Related]
10. Environmental Concentrations of the Type 2 Diabetes Medication Metformin and Its Transformation Product Guanylurea in Surface Water and Sediment in Ontario and Quebec, Canada. Littlejohn C; Renaud JB; Sabourin L; Lapen DR; Pappas JJ; Tuteja B; Hughes D; Ussery E; Yeung KK; Sumarah MW Environ Toxicol Chem; 2023 Aug; 42(8):1709-1720. PubMed ID: 37283207 [TBL] [Abstract][Full Text] [Related]
11. The elevated toxicity of the biodegradation product (guanylurea) from metformin and the antagonistic pattern recognition of combined toxicity: Insight from the pharmaceutical risk assessment and the simulated wastewater treatment. Gao F; Wen H; Feng S; Li M; Zhu L; Zhang Y; Xi Y; Xiang X Sci Total Environ; 2023 Sep; 892():164747. PubMed ID: 37295518 [TBL] [Abstract][Full Text] [Related]
12. A Methylotrophic Bacterium Growing with the Antidiabetic Drug Metformin as Its Sole Carbon, Nitrogen and Energy Source. Chaignaud P; Gruffaz C; Borreca A; Fouteau S; Kuhn L; Masbou J; Rouy Z; Hammann P; Imfeld G; Roche D; Vuilleumier S Microorganisms; 2022 Nov; 10(11):. PubMed ID: 36422372 [TBL] [Abstract][Full Text] [Related]
13. Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family. Lucero RM; Demirer K; Yeh TJ; Stockbridge RB J Gen Physiol; 2024 Mar; 156(3):. PubMed ID: 38294434 [TBL] [Abstract][Full Text] [Related]
14. Comprehensive study of the antidiabetic drug metformin and its transformation product guanylurea in Greek wastewaters. Kosma CI; Lambropoulou DA; Albanis TA Water Res; 2015 Mar; 70():436-48. PubMed ID: 25562582 [TBL] [Abstract][Full Text] [Related]
15. Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle. Trautwein C; Berset JD; Wolschke H; Kümmerer K Environ Int; 2014 Sep; 70():203-12. PubMed ID: 24954924 [TBL] [Abstract][Full Text] [Related]
16. Transport of metformin metabolites by guanidinium exporters of the Small Multidrug Resistance family. Lucero RM; Demirer K; Yeh TJ; Stockbridge RB bioRxiv; 2023 Aug; ():. PubMed ID: 37645731 [TBL] [Abstract][Full Text] [Related]
17. Biodegradation of metformin and guanylurea by aerobic cultures enriched from sludge. Briones RM; Zhuang WQ; Sarmah AK Environ Pollut; 2018 Dec; 243(Pt A):255-262. PubMed ID: 30179806 [TBL] [Abstract][Full Text] [Related]
18. Genome Sequences of Two Pseudomonas Isolates That Can Use Metformin as the Sole Nitrogen Source. Hillmann KB; Niehaus TD Microbiol Resour Announc; 2022 Sep; 11(9):e0063922. PubMed ID: 35980179 [TBL] [Abstract][Full Text] [Related]