BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

180 related articles for article (PubMed ID: 36608175)

  • 1. An Empirical Quantitative Structure-Activity Relationship Equation Assists the Discovery of High-Affinity Phosphodiesterase 4D Inhibitors as Leads to PET Radioligands.
    Jiang M; Lu S; Telu S; Pike VW
    J Med Chem; 2023 Jan; 66(2):1543-1561. PubMed ID: 36608175
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Robust Quantification of Phosphodiesterase-4D in Monkey Brain with PET and
    Jiang M; Tang S; Jenkins MD; Lee AC; Kenou B; Knoer C; Montero Santamaria J; Wu S; Liow JS; Zoghbi SS; Zanotti-Fregonara P; Innis RB; Telu S; Pike VW
    J Nucl Med; 2024 May; 65(5):788-793. PubMed ID: 38423785
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D.
    Wakabayashi Y; Telu S; Dick RM; Fujita M; Ooms M; Morse CL; Liow JS; Hong JS; Gladding RL; Manly LS; Zoghbi SS; Mo X; D'Amato EC; Sindac JA; Nugent RA; Marron BE; Gurney ME; Innis RB; Pike VW
    ACS Chem Neurosci; 2020 May; 11(9):1311-1323. PubMed ID: 32212718
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.
    Zhang L; Chen L; Beck EM; Chappie TA; Coelho RV; Doran SD; Fan KH; Helal CJ; Humphrey JM; Hughes Z; Kuszpit K; Lachapelle EA; Lazzaro JT; Lee C; Mather RJ; Patel NC; Skaddan MB; Sciabola S; Verhoest PR; Young JM; Zasadny K; Villalobos A
    J Med Chem; 2017 Oct; 60(20):8538-8551. PubMed ID: 28957634
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.
    Lodge NJ; Li YW; Chin FT; Dischino DD; Zoghbi SS; Deskus JA; Mattson RJ; Imaizumi M; Pieschl R; Molski TF; Fujita M; Dulac H; Zaczek R; Bronson JJ; Macor JE; Innis RB; Pike VW
    Nucl Med Biol; 2014 Jul; 41(6):524-35. PubMed ID: 24793011
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography.
    Schröder S; Wenzel B; Deuther-Conrad W; Teodoro R; Egerland U; Kranz M; Scheunemann M; Höfgen N; Steinbach J; Brust P
    Molecules; 2015 May; 20(6):9591-615. PubMed ID: 26016549
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.
    Aspiotis R; Deschênes D; Dubé D; Girard Y; Huang Z; Laliberté F; Liu S; Papp R; Nicholson DW; Young RN
    Bioorg Med Chem Lett; 2010 Sep; 20(18):5502-5. PubMed ID: 20709547
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of [
    Yang KC; Stepanov V; Amini N; Martinsson S; Takano A; Nielsen J; Bundgaard C; Bang-Andersen B; Grimwood S; Halldin C; Farde L; Finnema SJ
    Eur J Nucl Med Mol Imaging; 2017 Feb; 44(2):308-320. PubMed ID: 27817159
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of novel phosphodiesterase-4D inhibitors prescreened by molecular dynamics-augmented modeling and validated by bioassay.
    Li Z; Cai YH; Cheng YK; Lu X; Shao YX; Li X; Liu M; Liu P; Luo HB
    J Chem Inf Model; 2013 Apr; 53(4):972-81. PubMed ID: 23517293
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships.
    Zhou ZZ; Ge BC; Chen YF; Shi XD; Yang XM; Xu JP
    Bioorg Med Chem; 2015 Nov; 23(22):7332-9. PubMed ID: 26526739
    [TBL] [Abstract][Full Text] [Related]  

  • 11. PET measurement of the in vivo affinity of 11C-(R)-rolipram and the density of its target, phosphodiesterase-4, in the brains of conscious and anesthetized rats.
    Itoh T; Abe K; Zoghbi SS; Inoue O; Hong J; Imaizumi M; Pike VW; Innis RB; Fujita M
    J Nucl Med; 2009 May; 50(5):749-56. PubMed ID: 19372471
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.
    Zanotti-Fregonara P; Zhang Y; Jenko KJ; Gladding RL; Zoghbi SS; Fujita M; Sbardella G; Castellano S; Taliani S; Martini C; Innis RB; Da Settimo F; Pike VW
    ACS Chem Neurosci; 2014 Oct; 5(10):963-71. PubMed ID: 25123416
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.
    Andrés JI; De Angelis M; Alcázar J; Iturrino L; Langlois X; Dedeurwaerdere S; Lenaerts I; Vanhoof G; Celen S; Bormans G
    J Med Chem; 2011 Aug; 54(16):5820-35. PubMed ID: 21777010
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 3D-QSAR Studies on High-affinity Phosphodiestera.
    Shi L; Si H
    Curr Med Chem; 2024 Jan; ():. PubMed ID: 38231072
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Recent advances in positron emission tomography (PET) radiotracers for imaging phosphodiesterases.
    Andrés JI; De Angelis M; Alcázar J; Celen S; Bormans G
    Curr Top Med Chem; 2012; 12(11):1224-36. PubMed ID: 22571785
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.
    Zhang L; Villalobos A; Beck EM; Bocan T; Chappie TA; Chen L; Grimwood S; Heck SD; Helal CJ; Hou X; Humphrey JM; Lu J; Skaddan MB; McCarthy TJ; Verhoest PR; Wager TT; Zasadny K
    J Med Chem; 2013 Jun; 56(11):4568-79. PubMed ID: 23651455
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Carboxyl-
    Fisher MJ; McMurray L; Lu S; Morse CL; Liow JS; Zoghbi SS; Kowalski A; Tye GL; Innis RB; Aigbirhio FI; Pike VW
    ChemMedChem; 2018 Jan; 13(2):138-146. PubMed ID: 29232493
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.
    Harada A; Suzuki K; Miura S; Hasui T; Kamiguchi N; Ishii T; Taniguchi T; Kuroita T; Takano A; Stepanov V; Halldin C; Kimura H
    Nucl Med Biol; 2015 Feb; 42(2):146-54. PubMed ID: 25451212
    [TBL] [Abstract][Full Text] [Related]  

  • 19. First-in-Human Evaluation of
    Wakabayashi Y; Stenkrona P; Arakawa R; Yan X; Van Buskirk MG; Jenkins MD; Santamaria JAM; Maresca KP; Takano A; Liow JS; Chappie TA; Varrone A; Nag S; Zhang L; Hughes ZA; Schmidt CJ; Doran SD; Mannes A; Zanotti-Fregonara P; Ooms M; Morse CL; Zoghbi SS; Halldin C; Pike VW; Innis RB
    J Nucl Med; 2022 Dec; 63(12):1919-1924. PubMed ID: 35772961
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
    Huang Y; Bae SA; Zhu Z; Guo N; Roth BL; Laruelle M
    J Med Chem; 2005 Apr; 48(7):2559-70. PubMed ID: 15801845
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.