BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 36608671)

  • 1. GATOR2 rings GATOR1 to speak to mTORC1.
    Sahu U; Ben-Sahra I
    Mol Cell; 2023 Jan; 83(1):6-8. PubMed ID: 36608671
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ring domains are essential for GATOR2-dependent mTORC1 activation.
    Jiang C; Dai X; He S; Zhou H; Fang L; Guo J; Liu S; Zhang T; Pan W; Yu H; Fu T; Li D; Inuzuka H; Wang P; Xiao J; Wei W
    Mol Cell; 2023 Jan; 83(1):74-89.e9. PubMed ID: 36528027
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
    Chantranupong L; Wolfson RL; Orozco JM; Saxton RA; Scaria SM; Bar-Peled L; Spooner E; Isasa M; Gygi SP; Sabatini DM
    Cell Rep; 2014 Oct; 9(1):1-8. PubMed ID: 25263562
    [TBL] [Abstract][Full Text] [Related]  

  • 4. SZT2 dictates GATOR control of mTORC1 signalling.
    Peng M; Yin N; Li MO
    Nature; 2017 Mar; 543(7645):433-437. PubMed ID: 28199315
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
    Saxton RA; Knockenhauer KE; Wolfson RL; Chantranupong L; Pacold ME; Wang T; Schwartz TU; Sabatini DM
    Science; 2016 Jan; 351(6268):53-8. PubMed ID: 26586190
    [TBL] [Abstract][Full Text] [Related]  

  • 6. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
    Wolfson RL; Chantranupong L; Wyant GA; Gu X; Orozco JM; Shen K; Condon KJ; Petri S; Kedir J; Scaria SM; Abu-Remaileh M; Frankel WN; Sabatini DM
    Nature; 2017 Mar; 543(7645):438-442. PubMed ID: 28199306
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function.
    Cai W; Wei Y; Jarnik M; Reich J; Lilly MA
    PLoS Genet; 2016 May; 12(5):e1006036. PubMed ID: 27166823
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
    Bar-Peled L; Chantranupong L; Cherniack AD; Chen WW; Ottina KA; Grabiner BC; Spear ED; Carter SL; Meyerson M; Sabatini DM
    Science; 2013 May; 340(6136):1100-6. PubMed ID: 23723238
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.
    Jin G; Lee SW; Zhang X; Cai Z; Gao Y; Chou PC; Rezaeian AH; Han F; Wang CY; Yao JC; Gong Z; Chan CH; Huang CY; Tsai FJ; Tsai CH; Tu SH; Wu CH; Sarbassov dos D; Ho YS; Lin HK
    Mol Cell; 2015 Jun; 58(6):989-1000. PubMed ID: 26051179
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.
    Yan G; Yang J; Li W; Guo A; Guan J; Liu Y
    Nat Cell Biol; 2023 May; 25(5):754-764. PubMed ID: 37037994
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Wdr59 promotes or inhibits TORC1 activity depending on cellular context.
    Zhang Y; Ting CY; Yang S; Reich J; Fru K; Lilly MA
    Proc Natl Acad Sci U S A; 2023 Jan; 120(1):e2212330120. PubMed ID: 36577058
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
    Parmigiani A; Nourbakhsh A; Ding B; Wang W; Kim YC; Akopiants K; Guan KL; Karin M; Budanov AV
    Cell Rep; 2014 Nov; 9(4):1281-91. PubMed ID: 25457612
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of the nutrient-sensing hub GATOR2.
    Valenstein ML; Rogala KB; Lalgudi PV; Brignole EJ; Gu X; Saxton RA; Chantranupong L; Kolibius J; Quast JP; Sabatini DM
    Nature; 2022 Jul; 607(7919):610-616. PubMed ID: 35831510
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New insights into GATOR2-dependent interactions and its conformational changes in amino acid sensing.
    Yang C; Sun X; Wu G
    Biosci Rep; 2024 Mar; 44(3):. PubMed ID: 38372438
    [TBL] [Abstract][Full Text] [Related]  

  • 15. SPOP negatively regulates mTORC1 activity by ubiquitinating Sec13.
    Yang Y; Han YC; Cao Q; Wang X; Wei XD; Shang MD; Zhang XG; Li X; Hu B; Tian CY; Yang ZL; Liu KH; Wang JQ
    Cell Signal; 2024 Apr; 116():111060. PubMed ID: 38242269
    [TBL] [Abstract][Full Text] [Related]  

  • 16. GPCRs join the mTORC1 regulatory network.
    Puertollano R
    Nat Cell Biol; 2019 May; 21(5):538-539. PubMed ID: 31048767
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Sestrin2 is a leucine sensor for the mTORC1 pathway.
    Wolfson RL; Chantranupong L; Saxton RA; Shen K; Scaria SM; Cantor JR; Sabatini DM
    Science; 2016 Jan; 351(6268):43-8. PubMed ID: 26449471
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
    Kim JS; Ro SH; Kim M; Park HW; Semple IA; Park H; Cho US; Wang W; Guan KL; Karin M; Lee JH
    Sci Rep; 2015 Mar; 5():9502. PubMed ID: 25819761
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition.
    Figlia G; Müller S; Hagenston AM; Kleber S; Roiuk M; Quast JP; Ten Bosch N; Carvajal Ibañez D; Mauceri D; Martin-Villalba A; Teleman AA
    Nat Cell Biol; 2022 Sep; 24(9):1407-1421. PubMed ID: 36097071
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A multiprotein complex negatively regulates RAG GTPases and mTORC1.
    Cancer Discov; 2013 Jul; 3(7):OF24. PubMed ID: 23847368
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.