These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

264 related articles for article (PubMed ID: 36613762)

  • 1. Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours.
    Barszczewska-Pietraszek G; Drzewiecka M; Czarny P; Skorski T; Śliwiński T
    Int J Mol Sci; 2022 Dec; 24(1):. PubMed ID: 36613762
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Talazoparib enhances resection at DSBs and renders HR-proficient cancer cells susceptible to Polθ inhibition.
    Lin X; Soni A; Hessenow R; Sun Y; Mladenov E; Guberina M; Stuschke M; Iliakis G
    Radiother Oncol; 2024 Nov; 200():110475. PubMed ID: 39147034
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells.
    Sullivan-Reed K; Toma MM; Drzewiecka M; Nieborowska-Skorska M; Nejati R; Karami A; Wasik MA; Sliwinski T; Skorski T
    Mol Cancer Res; 2023 Oct; 21(10):1017-1022. PubMed ID: 37358557
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
    Ceccaldi R; Liu JC; Amunugama R; Hajdu I; Primack B; Petalcorin MI; O'Connor KW; Konstantinopoulos PA; Elledge SJ; Boulton SJ; Yusufzai T; D'Andrea AD
    Nature; 2015 Feb; 518(7538):258-62. PubMed ID: 25642963
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining.
    Ito F; Li Z; Minakhin L; Khant HA; Pomerantz RT; Chen XS
    bioRxiv; 2024 Jun; ():. PubMed ID: 38895274
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors.
    Bazan Russo TD; Mujacic C; Di Giovanni E; Vitale MC; Ferrante Bannera C; Randazzo U; Contino S; Bono M; Gristina V; Galvano A; Perez A; Badalamenti G; Russo A; Bazan V; Incorvaia L
    Cancer Gene Ther; 2024 Nov; 31(11):1619-1631. PubMed ID: 39122831
    [TBL] [Abstract][Full Text] [Related]  

  • 7. DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability.
    Brambati A; Barry RM; Sfeir A
    Curr Opin Genet Dev; 2020 Feb; 60():119-126. PubMed ID: 32302896
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas.
    Willman GH; Xu H; Zeigler TM; McIntosh MT; Bhaduri-McIntosh S
    J Virol; 2024 Jul; 98(7):e0057224. PubMed ID: 38860782
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection.
    Luedeman ME; Stroik S; Feng W; Luthman AJ; Gupta GP; Ramsden DA
    Nat Commun; 2022 Aug; 13(1):4547. PubMed ID: 35927262
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends.
    Schaub JM; Soniat MM; Finkelstein IJ
    Nucleic Acids Res; 2022 Apr; 50(7):3911-3921. PubMed ID: 35357490
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sequential requirements for distinct Polθ domains during theta-mediated end joining.
    Fijen C; Drogalis Beckham L; Terino D; Li Y; Ramsden DA; Wood RD; Doublié S; Rothenberg E
    Mol Cell; 2024 Apr; 84(8):1460-1474.e6. PubMed ID: 38640894
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthetic Lethality Targeting Polθ.
    Drzewiecka M; Barszczewska-Pietraszek G; Czarny P; Skorski T; Śliwiński T
    Genes (Basel); 2022 Jun; 13(6):. PubMed ID: 35741863
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
    Gelot C; Kovacs MT; Miron S; Mylne E; Haan A; Boeffard-Dosierre L; Ghouil R; Popova T; Dingli F; Loew D; Guirouilh-Barbat J; Del Nery E; Zinn-Justin S; Ceccaldi R
    Nature; 2023 Sep; 621(7978):415-422. PubMed ID: 37674080
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting Polymerase Theta (POLθ) for Cancer Therapy.
    Patterson-Fortin J; D'Andrea AD
    Cancer Treat Res; 2023; 186():285-298. PubMed ID: 37978141
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks.
    Vekariya U; Minakhin L; Chandramouly G; Tyagi M; Kent T; Sullivan-Reed K; Atkins J; Ralph D; Nieborowska-Skorska M; Kukuyan AM; Tang HY; Pomerantz RT; Skorski T
    Nat Commun; 2024 Jul; 15(1):5822. PubMed ID: 38987289
    [TBL] [Abstract][Full Text] [Related]  

  • 16. POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis.
    Llorens-Agost M; Ensminger M; Le HP; Gawai A; Liu J; Cruz-García A; Bhetawal S; Wood RD; Heyer WD; Löbrich M
    Nat Cell Biol; 2021 Oct; 23(10):1095-1104. PubMed ID: 34616022
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.
    Mateos-Gomez PA; Kent T; Deng SK; McDevitt S; Kashkina E; Hoang TM; Pomerantz RT; Sfeir A
    Nat Struct Mol Biol; 2017 Dec; 24(12):1116-1123. PubMed ID: 29058711
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analysis of chromatid-break-repair detects a homologous recombination to non-homologous end-joining switch with increasing load of DNA double-strand breaks.
    Murmann-Konda T; Soni A; Stuschke M; Iliakis G
    Mutat Res Genet Toxicol Environ Mutagen; 2021 Jul; 867():503372. PubMed ID: 34266628
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
    Zhou J; Gelot C; Pantelidou C; Li A; Yücel H; Davis RE; Färkkilä A; Kochupurakkal B; Syed A; Shapiro GI; Tainer JA; Blagg BSJ; Ceccaldi R; D'Andrea AD
    Nat Cancer; 2021 Jun; 2(6):598-610. PubMed ID: 34179826
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining.
    Ramsden DA; Carvajal-Garcia J; Gupta GP
    Nat Rev Mol Cell Biol; 2022 Feb; 23(2):125-140. PubMed ID: 34522048
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.