124 related articles for article (PubMed ID: 36629035)
1. Design of a dual-function agent by fusing a designed anti-VEGF-A binder and CPG-2 enzyme.
Etemadi A; Karimi-Jafari MH; Negahdari B; Asgari Y; Reza Khorramizadeh M; Mohammadian F; Mazloomi M
J Biomol Struct Dyn; 2023; 41(21):11463-11470. PubMed ID: 36629035
[TBL] [Abstract][Full Text] [Related]
2. Molecular modeling approach to predict a binding mode for the complex methotrexate-carboxypeptidase G2.
Turra KM; Pasqualoto KF; Ferreira EI; Rando DG
J Mol Model; 2012 May; 18(5):1867-75. PubMed ID: 21866317
[TBL] [Abstract][Full Text] [Related]
3. A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs.
Spooner RA; Friedlos F; Maycroft K; Stribbling SM; Roussel J; Brueggen J; Stolz B; O'Reilly T; Wood J; Matter A; Marais R; Springer CJ
Br J Cancer; 2003 May; 88(10):1622-30. PubMed ID: 12771932
[TBL] [Abstract][Full Text] [Related]
4. Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate.
Haenseler E; Esswein A; Vitols KS; Montejano Y; Mueller BM; Reisfeld RA; Huennekens FM
Biochemistry; 1992 Jan; 31(3):891-7. PubMed ID: 1731945
[TBL] [Abstract][Full Text] [Related]
5. Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site.
Aldughaim MS; Alsaffar F; Barker MD
Molecules; 2021 Jan; 26(3):. PubMed ID: 33504102
[TBL] [Abstract][Full Text] [Related]
6. Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate.
Smith GK; Banks S; Blumenkopf TA; Cory M; Humphreys J; Laethem RM; Miller J; Moxham CP; Mullin R; Ray PH; Walton LM; Wolfe LA
J Biol Chem; 1997 Jun; 272(25):15804-16. PubMed ID: 9188478
[TBL] [Abstract][Full Text] [Related]
7. Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.
Niculescu-Duvaz I; Scanlon I; Niculescu-Duvaz D; Friedlos F; Martin J; Marais R; Springer CJ
J Med Chem; 2004 May; 47(10):2651-8. PubMed ID: 15115406
[TBL] [Abstract][Full Text] [Related]
8. Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.
Davies LC; Friedlos F; Hedley D; Martin J; Ogilvie LM; Scanlon IJ; Springer CJ
J Med Chem; 2005 Aug; 48(16):5321-8. PubMed ID: 16078849
[TBL] [Abstract][Full Text] [Related]
9. Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.
Khan TH; Eno-Amooquaye EA; Searle F; Browne PJ; Osborn HM; Burke PJ
J Med Chem; 1999 Mar; 42(6):951-6. PubMed ID: 10090777
[TBL] [Abstract][Full Text] [Related]
10. Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs.
Hamstra DA; Pagé M; Maybaum J; Rehemtulla A
Cancer Res; 2000 Feb; 60(3):657-65. PubMed ID: 10676650
[TBL] [Abstract][Full Text] [Related]
11. Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.
Vitols KS; Haag-Zeino B; Baer T; Montejano YD; Huennekens FM
Cancer Res; 1995 Feb; 55(3):478-81. PubMed ID: 7834611
[TBL] [Abstract][Full Text] [Related]
12. Activation of prodrugs by antibody-enzyme conjugates: a new approach to cancer therapy.
Senter PD
FASEB J; 1990 Feb; 4(2):188-93. PubMed ID: 2404820
[TBL] [Abstract][Full Text] [Related]
13. A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy.
Marais R; Spooner RA; Stribbling SM; Light Y; Martin J; Springer CJ
Nat Biotechnol; 1997 Dec; 15(13):1373-7. PubMed ID: 9415889
[TBL] [Abstract][Full Text] [Related]
14. Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells.
Pinto JT; Suffoletto BP; Berzin TM; Qiao CH; Lin S; Tong WP; May F; Mukherjee B; Heston WD
Clin Cancer Res; 1996 Sep; 2(9):1445-51. PubMed ID: 9816319
[TBL] [Abstract][Full Text] [Related]
15. Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates.
Huennekens FM
Adv Enzyme Regul; 1997; 37():77-92. PubMed ID: 9381987
[TBL] [Abstract][Full Text] [Related]
16. Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs.
Springer CJ; Niculescu-Duvaz I
Anticancer Drug Des; 1995 Jul; 10(5):361-72. PubMed ID: 7639927
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.
Masterson LA; Spanswick VJ; Hartley JA; Begent RH; Howard PW; Thurston DE
Bioorg Med Chem Lett; 2006 Jan; 16(2):252-6. PubMed ID: 16290933
[TBL] [Abstract][Full Text] [Related]
18. Redox-Responsive and Dual-Targeting Hyaluronic Acid-Methotrexate Prodrug Self-Assembling Nanoparticles for Enhancing Intracellular Drug Self-Delivery.
Zhang Y; Li Y; Tian H; Zhu Q; Wang F; Fan Z; Zhou S; Wang X; Xie L; Hou Z
Mol Pharm; 2019 Jul; 16(7):3133-3144. PubMed ID: 31198046
[TBL] [Abstract][Full Text] [Related]
19. Association of GGH Promoter Methylation Levels with Methotrexate Concentrations in Chinese Children with Acute Lymphoblastic Leukemia.
Wang SM; Kong XY; Li M; Sun LL; Yan D
Pharmacotherapy; 2020 Jul; 40(7):614-622. PubMed ID: 32476160
[TBL] [Abstract][Full Text] [Related]
20. New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
Dowell RI; Springer CJ; Davies DH; Hadley EM; Burke PJ; Boyle FT; Melton RG; Connors TA; Blakey DC; Mauger AB
J Med Chem; 1996 Mar; 39(5):1100-5. PubMed ID: 8676345
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
