BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 36696267)

  • 1. FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration.
    Szewczyk B; Günther R; Japtok J; Frech MJ; Naumann M; Lee HO; Hermann A
    Cell Rep; 2023 Feb; 42(2):112025. PubMed ID: 36696267
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
    Daigle JG; Krishnamurthy K; Ramesh N; Casci I; Monaghan J; McAvoy K; Godfrey EW; Daniel DC; Johnson EM; Monahan Z; Shewmaker F; Pasinelli P; Pandey UB
    Acta Neuropathol; 2016 Apr; 131(4):605-20. PubMed ID: 26728149
    [TBL] [Abstract][Full Text] [Related]  

  • 3. RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.
    Daigle JG; Lanson NA; Smith RB; Casci I; Maltare A; Monaghan J; Nichols CD; Kryndushkin D; Shewmaker F; Pandey UB
    Hum Mol Genet; 2013 Mar; 22(6):1193-205. PubMed ID: 23257289
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.
    Tyzack GE; Luisier R; Taha DM; Neeves J; Modic M; Mitchell JS; Meyer I; Greensmith L; Newcombe J; Ule J; Luscombe NM; Patani R
    Brain; 2019 Sep; 142(9):2572-2580. PubMed ID: 31368485
    [TBL] [Abstract][Full Text] [Related]  

  • 5. ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons.
    Lenzi J; De Santis R; de Turris V; Morlando M; Laneve P; Calvo A; Caliendo V; Chiò A; Rosa A; Bozzoni I
    Dis Model Mech; 2015 Jul; 8(7):755-66. PubMed ID: 26035390
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.
    Akiyama T; Suzuki N; Ishikawa M; Fujimori K; Sone T; Kawada J; Funayama R; Fujishima F; Mitsuzawa S; Ikeda K; Ono H; Shijo T; Osana S; Shirota M; Nakagawa T; Kitajima Y; Nishiyama A; Izumi R; Morimoto S; Okada Y; Kamei T; Nishida M; Nogami M; Kaneda S; Ikeuchi Y; Mitsuhashi H; Nakayama K; Fujii T; Warita H; Okano H; Aoki M
    EBioMedicine; 2019 Jul; 45():362-378. PubMed ID: 31262712
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons.
    Ryu HH; Jun MH; Min KJ; Jang DJ; Lee YS; Kim HK; Lee JA
    Neurobiol Aging; 2014 Dec; 35(12):2822-2831. PubMed ID: 25216585
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stress-Specific Spatiotemporal Responses of RNA-Binding Proteins in Human Stem-Cell-Derived Motor Neurons.
    Harley J; Patani R
    Int J Mol Sci; 2020 Nov; 21(21):. PubMed ID: 33172210
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis.
    Lim SM; Choi WJ; Oh KW; Xue Y; Choi JY; Kim SH; Nahm M; Kim YE; Lee J; Noh MY; Lee S; Hwang S; Ki CS; Fu XD; Kim SH
    Mol Neurodegener; 2016 Jan; 11():8. PubMed ID: 26795035
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The fused in sarcoma protein forms cytoplasmic aggregates in motor neurons derived from integration-free induced pluripotent stem cells generated from a patient with familial amyotrophic lateral sclerosis carrying the FUS-P525L mutation.
    Liu X; Chen J; Liu W; Li X; Chen Q; Liu T; Gao S; Deng M
    Neurogenetics; 2015 Jul; 16(3):223-31. PubMed ID: 25912081
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.
    De Santis R; Alfano V; de Turris V; Colantoni A; Santini L; Garone MG; Antonacci G; Peruzzi G; Sudria-Lopez E; Wyler E; Anink JJ; Aronica E; Landthaler M; Pasterkamp RJ; Bozzoni I; Rosa A
    Cell Rep; 2019 Jun; 27(13):3818-3831.e5. PubMed ID: 31242416
    [TBL] [Abstract][Full Text] [Related]  

  • 12. ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity.
    An H; Litscher G; Watanabe N; Wei W; Hashimoto T; Iwatsubo T; Buchman VL; Shelkovnikova TA
    Neurobiol Dis; 2022 Jan; 162():105585. PubMed ID: 34915152
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
    Naumann M; Pal A; Goswami A; Lojewski X; Japtok J; Vehlow A; Naujock M; Günther R; Jin M; Stanslowsky N; Reinhardt P; Sterneckert J; Frickenhaus M; Pan-Montojo F; Storkebaum E; Poser I; Freischmidt A; Weishaupt JH; Holzmann K; Troost D; Ludolph AC; Boeckers TM; Liebau S; Petri S; Cordes N; Hyman AA; Wegner F; Grill SW; Weis J; Storch A; Hermann A
    Nat Commun; 2018 Jan; 9(1):335. PubMed ID: 29362359
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging.
    Japtok J; Lojewski X; Naumann M; Klingenstein M; Reinhardt P; Sterneckert J; Putz S; Demestre M; Boeckers TM; Ludolph AC; Liebau S; Storch A; Hermann A
    Neurobiol Dis; 2015 Oct; 82():420-429. PubMed ID: 26253605
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay.
    Kamelgarn M; Chen J; Kuang L; Jin H; Kasarskis EJ; Zhu H
    Proc Natl Acad Sci U S A; 2018 Dec; 115(51):E11904-E11913. PubMed ID: 30455313
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.
    Guo W; Naujock M; Fumagalli L; Vandoorne T; Baatsen P; Boon R; Ordovás L; Patel A; Welters M; Vanwelden T; Geens N; Tricot T; Benoy V; Steyaert J; Lefebvre-Omar C; Boesmans W; Jarpe M; Sterneckert J; Wegner F; Petri S; Bohl D; Vanden Berghe P; Robberecht W; Van Damme P; Verfaillie C; Van Den Bosch L
    Nat Commun; 2017 Oct; 8(1):861. PubMed ID: 29021520
    [TBL] [Abstract][Full Text] [Related]  

  • 17. ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.
    Vance C; Scotter EL; Nishimura AL; Troakes C; Mitchell JC; Kathe C; Urwin H; Manser C; Miller CC; Hortobágyi T; Dragunow M; Rogelj B; Shaw CE
    Hum Mol Genet; 2013 Jul; 22(13):2676-88. PubMed ID: 23474818
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.
    Zhu Y; Burg T; Neyrinck K; Vervliet T; Nami F; Vervoort E; Ahuja K; Sassano ML; Chai YC; Tharkeshwar AK; De Smedt J; Hu H; Bultynck G; Agostinis P; Swinnen JV; Van Den Bosch L; da Costa RFM; Verfaillie C
    Acta Neuropathol; 2024 Jan; 147(1):6. PubMed ID: 38170217
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS.
    Ito D; Suzuki N
    Neurology; 2011 Oct; 77(17):1636-43. PubMed ID: 21956718
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma.
    Bentmann E; Haass C; Dormann D
    FEBS J; 2013 Sep; 280(18):4348-70. PubMed ID: 23587065
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.