188 related articles for article (PubMed ID: 36750593)
1. In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents.
Ibrahim MAA; Abdeljawaad KAA; Roshdy E; Mohamed DEM; Ali TFS; Gabr GA; Jaragh-Alhadad LA; Mekhemer GAH; Shawky AM; Sidhom PA; Abdelrahman AHM
Sci Rep; 2023 Feb; 13(1):2146. PubMed ID: 36750593
[TBL] [Abstract][Full Text] [Related]
2.
Almansour NM; Allemailem KS; Abd El Aty AA; Ismail EIF; Ibrahim MAA
Molecules; 2023 Jan; 28(2):. PubMed ID: 36677841
[TBL] [Abstract][Full Text] [Related]
3. Hit evaluation results in 5-benzyl-1,3,4-thiadiazole-2-carboxamide based SIRT2-selective inhibitor with improved affinity and selectivity.
Gozelle M; Kaya SG; Aksel AB; Ozkan E; Bakar-Ates F; Ozkan Y; Eren G
Bioorg Chem; 2022 Jun; 123():105746. PubMed ID: 35358824
[TBL] [Abstract][Full Text] [Related]
4. Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
Radwan MO; Ciftci HI; Ali TFS; Koga R; Tateishi H; Nakata A; Ito A; Yoshida M; Fujita M; Otsuka M
Bioorg Med Chem Lett; 2020 Oct; 30(19):127458. PubMed ID: 32755678
[TBL] [Abstract][Full Text] [Related]
5. Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations.
Sakkiah S; Arooj M; Kumar MR; Eom SH; Lee KW
PLoS One; 2013; 8(1):e51429. PubMed ID: 23382805
[TBL] [Abstract][Full Text] [Related]
6. Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis.
Huang S; Song C; Wang X; Zhang G; Wang Y; Jiang X; Sun Q; Huang L; Xiang R; Hu Y; Li L; Yang S
J Chem Inf Model; 2017 Apr; 57(4):669-679. PubMed ID: 28301150
[TBL] [Abstract][Full Text] [Related]
7. Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
Bharadwaj S; Dubey A; Kamboj NK; Sahoo AK; Kang SG; Yadava U
Sci Rep; 2021 May; 11(1):10169. PubMed ID: 33986372
[TBL] [Abstract][Full Text] [Related]
8. Exploring Natural Product Activity and Species Source Candidates for Hunting ABCB1 Transporter Inhibitors: An In Silico Drug Discovery Study.
Ibrahim MAA; Abdeljawaad KAA; Abdelrahman AHM; Jaragh-Alhadad LA; Oraby HF; Elkaeed EB; Mekhemer GAH; Gabr GA; Shawky AM; Sidhom PA; Soliman MES; Moustafa MF; Paré PW; Hegazy MF
Molecules; 2022 May; 27(10):. PubMed ID: 35630581
[TBL] [Abstract][Full Text] [Related]
9. Screening approach by a combination of computational and in vitro experiments: identification of fluvastatin sodium as a potential SIRT2 inhibitor.
Yang J; Wang H; Liu J; Ma E; Jin X; Li Y; Ma C
J Mol Model; 2024 May; 30(6):188. PubMed ID: 38801625
[TBL] [Abstract][Full Text] [Related]
10. Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
Yang L; Ma X; Yuan C; He Y; Li L; Fang S; Xia W; He T; Qian S; Xu Z; Li G; Wang Z
Eur J Med Chem; 2017 Jul; 134():230-241. PubMed ID: 28415012
[TBL] [Abstract][Full Text] [Related]
11. Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities.
Spiegelman NA; Price IR; Jing H; Wang M; Yang M; Cao J; Hong JY; Zhang X; Aramsangtienchai P; Sadhukhan S; Lin H
ChemMedChem; 2018 Sep; 13(18):1890-1894. PubMed ID: 30058233
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
Manjula R; Gokhale N; Unni S; Deshmukh P; Reddyrajula R; Srinivas Bharath MM; Dalimba U; Padmanabhan B
Bioorg Chem; 2019 Nov; 92():103281. PubMed ID: 31561106
[TBL] [Abstract][Full Text] [Related]
13. Molecular docking and dynamics simulation, receptor-based hypothesis: application to identify novel sirtuin 2 inhibitors.
Sakkiah S; Thangapandian S; Park C; Son M; Lee KW
Chem Biol Drug Des; 2012 Aug; 80(2):315-27. PubMed ID: 22564257
[TBL] [Abstract][Full Text] [Related]
14. Venetoclax analogs as promising anticancer therapeutics via targeting Bcl-2 protein:
Almansour NM; Allemailem KS; Abd El Aty AA; Boussoufa D; Ismail Fagiree E; Ibrahim MAA
J Biomol Struct Dyn; 2023; 41(23):14308-14324. PubMed ID: 36815250
[TBL] [Abstract][Full Text] [Related]
15. Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics.
Djokovic N; Ruzic D; Rahnasto-Rilla M; Srdic-Rajic T; Lahtela-Kakkonen M; Nikolic K
J Chem Inf Model; 2022 May; 62(10):2571-2585. PubMed ID: 35467856
[TBL] [Abstract][Full Text] [Related]
16. Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD
Mellini P; Itoh Y; Elboray EE; Tsumoto H; Li Y; Suzuki M; Takahashi Y; Tojo T; Kurohara T; Miyake Y; Miura Y; Kitao Y; Kotoku M; Iida T; Suzuki T
J Med Chem; 2019 Jun; 62(12):5844-5862. PubMed ID: 31144814
[TBL] [Abstract][Full Text] [Related]
17. Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
Sundriyal S; Moniot S; Mahmud Z; Yao S; Di Fruscia P; Reynolds CR; Dexter DT; Sternberg MJ; Lam EW; Steegborn C; Fuchter MJ
J Med Chem; 2017 Mar; 60(5):1928-1945. PubMed ID: 28135086
[TBL] [Abstract][Full Text] [Related]
18. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Rumpf T; Schiedel M; Karaman B; Roessler C; North BJ; Lehotzky A; Oláh J; Ladwein KI; Schmidtkunz K; Gajer M; Pannek M; Steegborn C; Sinclair DA; Gerhardt S; Ovádi J; Schutkowski M; Sippl W; Einsle O; Jung M
Nat Commun; 2015 Feb; 6():6263. PubMed ID: 25672491
[TBL] [Abstract][Full Text] [Related]
19. Identification of novel Plasmodium falciparum PI4KB inhibitors as potential anti-malarial drugs: Homology modeling, molecular docking and molecular dynamics simulations.
Ibrahim MAA; Abdelrahman AHM; Hassan AMA
Comput Biol Chem; 2019 Jun; 80():79-89. PubMed ID: 30928871
[TBL] [Abstract][Full Text] [Related]
20. Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Farooqi AS; Hong JY; Cao J; Lu X; Price IR; Zhao Q; Kosciuk T; Yang M; Bai JJ; Lin H
J Med Chem; 2019 Apr; 62(8):4131-4141. PubMed ID: 30986062
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
