179 related articles for article (PubMed ID: 36768458)
1. New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.
Ferrisi R; Polini B; Ricardi C; Gado F; Mohamed KA; Baron G; Faiella S; Poli G; Rapposelli S; Saccomanni G; Aldini G; Chiellini G; Laprairie RB; Manera C; Ortore G
Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768458
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB
Ferrisi R; Gado F; Polini B; Ricardi C; Mohamed KA; Stevenson LA; Ortore G; Rapposelli S; Saccomanni G; Pertwee RG; Laprairie RB; Manera C; Chiellini G
Front Chem; 2022; 10():984069. PubMed ID: 36238097
[TBL] [Abstract][Full Text] [Related]
3. Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
Gado F; Ferrisi R; Polini B; Mohamed KA; Ricardi C; Lucarini E; Carpi S; Domenichini F; Stevenson LA; Rapposelli S; Saccomanni G; Nieri P; Ortore G; Pertwee RG; Ghelardini C; Di Cesare Mannelli L; Chiellini G; Laprairie RB; Manera C
J Med Chem; 2022 Jul; 65(14):9918-9938. PubMed ID: 35849804
[TBL] [Abstract][Full Text] [Related]
4. Bridging the Binding Sites 2.0: Photoswitchable Dualsteric Ligands for the Cannabinoid 2 Receptor.
Steinmüller SAM; Tutov A; Hislop JN; Decker M
ACS Chem Neurosci; 2023 Oct; 14(20):3737-3744. PubMed ID: 37792463
[TBL] [Abstract][Full Text] [Related]
5. Recent Advances in the Drug Discovery and Development of Dualsteric/ Bitopic Activators of G Protein-Coupled Receptors.
Reinecke BA; Wang H; Zhang Y
Curr Top Med Chem; 2019; 19(26):2378-2392. PubMed ID: 31833462
[TBL] [Abstract][Full Text] [Related]
6. Designing drugs and chemical probes with the dualsteric approach.
Zha J; He J; Wu C; Zhang M; Liu X; Zhang J
Chem Soc Rev; 2023 Dec; 52(24):8651-8677. PubMed ID: 37990599
[TBL] [Abstract][Full Text] [Related]
7. Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
Mohr K; Schmitz J; Schrage R; Tränkle C; Holzgrabe U
Angew Chem Int Ed Engl; 2013 Jan; 52(2):508-16. PubMed ID: 23225228
[TBL] [Abstract][Full Text] [Related]
8. Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.
Feng Z; Hu G; Ma S; Xie XQ
AAPS J; 2015 Sep; 17(5):1080-95. PubMed ID: 25940084
[TBL] [Abstract][Full Text] [Related]
9. Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist.
Polini B; Cervetto C; Carpi S; Pelassa S; Gado F; Ferrisi R; Bertini S; Nieri P; Marcoli M; Manera C
Life (Basel); 2020 Dec; 10(12):. PubMed ID: 33302569
[TBL] [Abstract][Full Text] [Related]
10. Dopamine D2 Receptors Dimers: How can we Pharmacologically Target Them?
Carli M; Kolachalam S; Aringhieri S; Rossi M; Giovannini L; Maggio R; Scarselli M
Curr Neuropharmacol; 2018 Jan; 16(2):222-230. PubMed ID: 28521704
[TBL] [Abstract][Full Text] [Related]
11. Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology.
Braga Emidio N; Small BM; Keller AR; Cheloha RW; Wingler LM
Mol Pharmacol; 2024 Feb; 105(3):260-271. PubMed ID: 38164609
[TBL] [Abstract][Full Text] [Related]
12. Exploration of the orthosteric/allosteric interface in human M1 muscarinic receptors by bitopic fluorescent ligands.
Daval SB; Kellenberger E; Bonnet D; Utard V; Galzi JL; Ilien B
Mol Pharmacol; 2013 Jul; 84(1):71-85. PubMed ID: 23604140
[TBL] [Abstract][Full Text] [Related]
13. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.
Fronik P; Gaiser BI; Sejer Pedersen D
J Med Chem; 2017 May; 60(10):4126-4134. PubMed ID: 28140580
[TBL] [Abstract][Full Text] [Related]
14. Computational insights into the molecular mechanisms of differentiated allosteric modulation at the mu opioid receptor by structurally similar bitopic modulators.
Wang H; Reinecke BA; Zhang Y
J Comput Aided Mol Des; 2020 Aug; 34(8):879-895. PubMed ID: 32193867
[TBL] [Abstract][Full Text] [Related]
15. Negative allosteric modulators of cannabinoid receptor 2: protein modeling, binding site identification and molecular dynamics simulations in the presence of an orthosteric agonist.
Pandey P; Roy KK; Doerksen RJ
J Biomol Struct Dyn; 2020 Jan; 38(1):32-47. PubMed ID: 30652534
[TBL] [Abstract][Full Text] [Related]
16. Rational design of dualsteric GPCR ligands: quests and promise.
Mohr K; Tränkle C; Kostenis E; Barocelli E; De Amici M; Holzgrabe U
Br J Pharmacol; 2010 Mar; 159(5):997-1008. PubMed ID: 20136835
[TBL] [Abstract][Full Text] [Related]
17. A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by β-Amyloid in Glial Cells.
Polini B; Zallocco L; Gado F; Ferrisi R; Ricardi C; Zuccarini M; Carnicelli V; Manera C; Ronci M; Lucacchini A; Zucchi R; Giusti L; Chiellini G
Cells; 2024 May; 13(10):. PubMed ID: 38786097
[TBL] [Abstract][Full Text] [Related]
18. Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.
Laprairie RB; Kulkarni AR; Kulkarni PM; Hurst DP; Lynch D; Reggio PH; Janero DR; Pertwee RG; Stevenson LA; Kelly ME; Denovan-Wright EM; Thakur GA
ACS Chem Neurosci; 2016 Jun; 7(6):776-98. PubMed ID: 27046127
[TBL] [Abstract][Full Text] [Related]
19. The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.
Valant C; Robert Lane J; Sexton PM; Christopoulos A
Annu Rev Pharmacol Toxicol; 2012; 52():153-78. PubMed ID: 21910627
[TBL] [Abstract][Full Text] [Related]
20. Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor.
Keov P; López L; Devine SM; Valant C; Lane JR; Scammells PJ; Sexton PM; Christopoulos A
J Biol Chem; 2014 Aug; 289(34):23817-37. PubMed ID: 25006252
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]