BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 36773804)

  • 1. Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.
    Petrunak EM; Bart AG; Peng HM; Auchus RJ; Scott EE
    J Biol Chem; 2023 Mar; 299(3):102999. PubMed ID: 36773804
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.
    DeVore NM; Scott EE
    Nature; 2012 Jan; 482(7383):116-9. PubMed ID: 22266943
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.
    Attard G; Reid AH; Auchus RJ; Hughes BA; Cassidy AM; Thompson E; Oommen NB; Folkerd E; Dowsett M; Arlt W; de Bono JS
    J Clin Endocrinol Metab; 2012 Feb; 97(2):507-16. PubMed ID: 22170708
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparative study of the binding mode between cytochrome P450 17A1 and prostate cancer drugs in the absence of haem iron.
    Song D; Zhang J; Wang Y; Hu J; Xu S; Xu Y; Shen H; Wen X; Sun Z
    J Biomol Struct Dyn; 2019 Oct; 37(16):4161-4170. PubMed ID: 30431391
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone.
    Garrido M; Peng HM; Yoshimoto FK; Upadhyay SK; Bratoeff E; Auchus RJ
    J Steroid Biochem Mol Biol; 2014 Sep; 143():1-10. PubMed ID: 24508512
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A bypass mechanism of abiraterone-resistant prostate cancer: Accumulating CYP17A1 substrates activate androgen receptor signaling.
    Moll JM; Kumagai J; van Royen ME; Teubel WJ; van Soest RJ; French PJ; Homma Y; Jenster G; de Wit R; van Weerden WM
    Prostate; 2019 Jun; 79(9):937-948. PubMed ID: 31017696
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1.
    Petrunak EM; Rogers SA; Aubé J; Scott EE
    Drug Metab Dispos; 2017 Jun; 45(6):635-645. PubMed ID: 28373265
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
    Fehl C; Vogt CD; Yadav R; Li K; Scott EE; Aubé J
    J Med Chem; 2018 Jun; 61(11):4946-4960. PubMed ID: 29792703
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structures of human steroidogenic cytochrome P450 17A1 with substrates.
    Petrunak EM; DeVore NM; Porubsky PR; Scott EE
    J Biol Chem; 2014 Nov; 289(47):32952-64. PubMed ID: 25301938
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone.
    de Mello Martins AGG; Allegretta G; Unteregger G; Haupenthal J; Eberhard J; Hoffmann M; van der Zee JA; Junker K; Stöckle M; Müller R; Hartmann RW; Ohlmann CH
    J Steroid Biochem Mol Biol; 2017 Nov; 174():183-191. PubMed ID: 28890368
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors.
    Bonomo S; Hansen CH; Petrunak EM; Scott EE; Styrishave B; Jørgensen FS; Olsen L
    Sci Rep; 2016 Jul; 6():29468. PubMed ID: 27406023
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2.
    Malikova J; Brixius-Anderko S; Udhane SS; Parween S; Dick B; Bernhardt R; Pandey AV
    J Steroid Biochem Mol Biol; 2017 Nov; 174():192-200. PubMed ID: 28893623
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro.
    Gent R; du Toit T; Swart AC
    J Steroid Biochem Mol Biol; 2019 Jul; 191():105369. PubMed ID: 31039398
    [TBL] [Abstract][Full Text] [Related]  

  • 14. CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.
    van Rooyen D; Yadav R; Scott EE; Swart AC
    J Steroid Biochem Mol Biol; 2020 May; 199():105614. PubMed ID: 32007561
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents.
    Wróbel TM; Rogova O; Andersen KL; Yadav R; Brixius-Anderko S; Scott EE; Olsen L; Jørgensen FS; Björkling F
    Int J Mol Sci; 2020 Jul; 21(14):. PubMed ID: 32660148
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis.
    Guengerich FP; McCarty KD; Chapman JG; Tateishi Y
    J Biol Chem; 2021 Aug; 297(2):100969. PubMed ID: 34273352
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparisons of Prostate Cancer Inhibitors Abiraterone and TOK-001 Binding with CYP17A1 through Molecular Dynamics.
    Xiao F; Yang M; Xu Y; Vongsangnak W
    Comput Struct Biotechnol J; 2015; 13():520-7. PubMed ID: 26682016
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.
    Estrada DF; Laurence JS; Scott EE
    J Biol Chem; 2013 Jun; 288(23):17008-17018. PubMed ID: 23620596
    [TBL] [Abstract][Full Text] [Related]  

  • 19. N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.
    Brossard D; Zhang Y; Haider SM; Sgobba M; Khalid M; Legay R; Duterque-Coquillaud M; Galera P; Rault S; Dallemagne P; Moslemi S; El Kihel L
    Chem Biol Drug Des; 2013 Nov; 82(5):620-9. PubMed ID: 23906044
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.
    Li A; Yadav R; White JK; Herroon MK; Callahan BP; Podgorski I; Turro C; Scott EE; Kodanko JJ
    Chem Commun (Camb); 2017 Mar; 53(26):3673-3676. PubMed ID: 28304025
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.