BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 36831007)

  • 1. Peptides That Block RAS-p21 Protein-Induced Cell Transformation.
    Pincus MR; Lin B; Patel P; Gabutan E; Zohar N; Bowne WB
    Biomedicines; 2023 Feb; 11(2):. PubMed ID: 36831007
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of new anti-cancer peptides from conformational energy analysis of the oncogenic ras-p21 protein and its complexes with target proteins.
    Pincus MR
    Front Biosci; 2004 Sep; 9():3486-509. PubMed ID: 15353372
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Comparison of the computed three-dimensional structures of oncogenic forms (bound to GDP) of the ras-gene-encoded p21 protein with the structure of the normal (non-transforming) wild-type protein.
    Monaco R; Chen JM; Chung D; Brandt-Rauf P; Pincus MR
    J Protein Chem; 1995 Aug; 14(6):457-66. PubMed ID: 8593186
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparison of the low energy conformations of an oncogenic and a non-oncogenic p21 protein, neither of which binds GTP or GDP.
    Liwo A; Gibson KD; Scheraga HA; Brandt-Rauf PW; Monaco R; Pincus MR
    J Protein Chem; 1994 Feb; 13(2):237-51. PubMed ID: 8060496
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.
    Kanovsky M; Michl J; Botzolaki G; Morin J; Kovac C; Chung DL; Chie L; Friedman FK; Pincus MR
    Cancer Chemother Pharmacol; 2003 Sep; 52(3):202-8. PubMed ID: 12783204
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Specificity of inhibition of ras-p21 signal transduction by peptides from GTPase activating protein (GAP) and the son-of sevenless (SOS) ras-specific guanine nucleotide exchange protein.
    Chie L; Chung D; Pincus MR
    Protein J; 2005 May; 24(4):253-8. PubMed ID: 16283548
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Anti-cancer peptides from ras-p21 and p53 proteins.
    Pincus MR; Fenelus M; Sarafraz-Yazdi E; Adler V; Bowne W; Michl J
    Curr Pharm Des; 2011; 17(25):2677-98. PubMed ID: 21728981
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activated conformations of the ras-gene-encoded p21 protein. 1. An energy-refined structure for the normal p21 protein complexed with GDP.
    Dykes DC; Brandt-Rauf P; Luster SM; Chung D; Friedman FK; Pincus MR
    J Biomol Struct Dyn; 1992 Jun; 9(6):1025-44. PubMed ID: 1637501
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oncogenic and activated wild-type ras-p21 proteins induce different isoforms of protein kinase C in mitogenic signal transduction.
    Chie L; Qu Y; Chung D; Boutjdir M; Pincus MR
    J Protein Chem; 2003 Nov; 22(7-8):625-9. PubMed ID: 14714729
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Oncogenic amino acid substitutions in the inhibitory rap-1A protein cause it to adopt a ras-p21-like conformation as computed using molecular dynamics.
    Chen JM; Brandt-Rauf PW; Pincus MR
    J Biomol Struct Dyn; 1996 Jun; 13(6):925-33. PubMed ID: 8832375
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A peptide from a ras effector-domain blocks ras-dependent cardiac hypertrophy in myocytes.
    Deng L; Boujdir M; Tremontano A; Pincus MR; El-Sherif N
    Ann Clin Lab Sci; 2009; 39(4):351-60. PubMed ID: 19880762
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Comparison of the computed structures for the phosphate-binding loop of the p21 protein containing the oncogenic site Gly 12 with the X-ray crystallographic structures for this region in the p21 protein and EFtu. A model for the structure of the p21 protein in its oncogenic form.
    Chen JM; Lee G; Murphy RB; Carty RP; Brandt-Rauf PW; Friedman E; Pincus MR
    J Biomol Struct Dyn; 1989 Apr; 6(5):859-75. PubMed ID: 2686707
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells.
    Adler V; Bowne W; Kamran I; Michl J; Friedman FK; Chin E; Zenilman M; Pincus MR
    Cancer Chemother Pharmacol; 2008 Aug; 62(3):491-8. PubMed ID: 18066549
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer.
    Bowne WB; Michl J; Bluth MH; Zenilman ME; Pincus MR
    Cancer Ther; 2007; 5B():331-344. PubMed ID: 18007958
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A protein methyl transferase, PRMT5, selectively blocks oncogenic ras-p21 mitogenic signal transduction.
    Chie L; Cook JR; Chung D; Hoffmann R; Yang Z; Kim Y; Pestka S; Pincus MR
    Ann Clin Lab Sci; 2003; 33(2):200-7. PubMed ID: 12817625
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas.
    Garlick DS; Sukumar S; Barbacid M; Petit D; Hamer PJ; Leav I; Lavecchio JA; Trimpe KL; Carney WP
    Hybridoma; 1991 Feb; 10(1):95-102. PubMed ID: 2032737
    [TBL] [Abstract][Full Text] [Related]  

  • 17. KRAS: From undruggable to a druggable Cancer Target.
    Uprety D; Adjei AA
    Cancer Treat Rev; 2020 Sep; 89():102070. PubMed ID: 32711246
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the guanine-nucleotide exchange protein, SOS, identified from molecular dynamics calculations. Selective inhibition of oncogenic ras-p21.
    Chie L; Chen JM; Friedman FK; Chung DL; Amar S; Michl J; Yamaizumi Z; Brandt-Rauf PW; Pincus MR
    J Protein Chem; 1999 Nov; 18(8):875-9. PubMed ID: 10839624
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular dynamics of the H-ras gene-encoded p21 protein; identification of flexible regions and possible effector domains.
    Dykes DC; Friedman FK; Dykes SL; Murphy RB; Brandt-Rauf PW; Pincus MR
    J Biomol Struct Dyn; 1993 Dec; 11(3):443-58. PubMed ID: 8129867
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation.
    Kovac C; Clie L; Morin J; Friedman FK; Robinson R; Chung DL; Kanovsky M; Flom J; Brandt-Rauf PW; Yamaizumi Z; Michl J; Pincus MR
    Cancer Chemother Pharmacol; 2001 Jul; 48(1):9-14. PubMed ID: 11488531
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.