BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 36841758)

  • 1. A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.
    Numata M; Haginoya N; Shiroishi M; Hirata T; Sato-Otsubo A; Yoshikawa K; Takata Y; Nagase R; Kashimoto Y; Suzuki M; Schulte N; Polier G; Kurimoto A; Tomoe Y; Toyota A; Yoneyama T; Imai E; Watanabe K; Hamada T; Kanada R; Watanabe J; Kagoshima Y; Tokumaru E; Murata K; Baba T; Shinozaki T; Ohtsuka M; Goto K; Karibe T; Deguchi T; Gocho Y; Yoshida M; Tomizawa D; Kato M; Tsutsumi S; Kitagawa M; Abe Y
    Cancer Cell Int; 2023 Feb; 23(1):36. PubMed ID: 36841758
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
    Heikamp EB; Henrich JA; Perner F; Wong EM; Hatton C; Wen Y; Barwe SP; Gopalakrishnapillai A; Xu H; Uckelmann HJ; Takao S; Kazansky Y; Pikman Y; McGeehan GM; Kolb EA; Kentsis A; Armstrong SA
    Blood; 2022 Feb; 139(6):894-906. PubMed ID: 34582559
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c).
    Fiskus W; Boettcher S; Daver N; Mill CP; Sasaki K; Birdwell CE; Davis JA; Takahashi K; Kadia TM; DiNardo CD; Jin Q; Qi Y; Su X; McGeehan GM; Khoury JD; Ebert BL; Bhalla KN
    Blood Cancer J; 2022 Jan; 12(1):5. PubMed ID: 35017466
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
    Klossowski S; Miao H; Kempinska K; Wu T; Purohit T; Kim E; Linhares BM; Chen D; Jih G; Perkey E; Huang H; He M; Wen B; Wang Y; Yu K; Lee SC; Danet-Desnoyers G; Trotman W; Kandarpa M; Cotton A; Abdel-Wahab O; Lei H; Dou Y; Guzman M; Peterson L; Gruber T; Choi S; Sun D; Ren P; Li LS; Liu Y; Burrows F; Maillard I; Cierpicki T; Grembecka J
    J Clin Invest; 2020 Feb; 130(2):981-997. PubMed ID: 31855575
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
    Bourgeois W; Cutler JA; Aubrey BJ; Wenge DV; Perner F; Martucci C; Henrich JA; Klega K; Nowak RP; Donovan KA; Boileau M; Wen Y; Hatton C; Apazidis AA; Olsen SN; Kirmani N; Pikman Y; Pollard JA; Perry JA; Sperling AS; Ebert BL; McGeehan GM; Crompton BD; Fischer ES; Armstrong SA
    Blood; 2024 Apr; 143(15):1513-1527. PubMed ID: 38096371
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.
    Uckelmann HJ; Haarer EL; Takeda R; Wong EM; Hatton C; Marinaccio C; Perner F; Rajput M; Antonissen NJC; Wen Y; Yang L; Brunetti L; Chen CW; Armstrong SA
    Cancer Discov; 2023 Mar; 13(3):746-765. PubMed ID: 36455613
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Menin-MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers.
    Shi Q; Xu M; Kang Z; Zhang M; Luo Y
    Molecules; 2023 Mar; 28(7):. PubMed ID: 37049787
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Imidazoquinoxaline derivative EAPB0503: A promising drug targeting mutant nucleophosmin 1 in acute myeloid leukemia.
    Nabbouh AI; Hleihel RS; Saliba JL; Karam MM; Hamie MH; Wu HJM; Berthier CP; Tawil NM; Bonnet PA; Deleuze-Masquefa C; El Hajj HA
    Cancer; 2017 May; 123(9):1662-1673. PubMed ID: 28055106
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.
    Chen Y; Jones KL; Anastassiadis K; Kranz A; Stewart AF; Grembecka J; Meyerson M; Ernst P
    Exp Hematol; 2019 Jan; 69():37-42. PubMed ID: 30315824
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.
    Kühn MW; Song E; Feng Z; Sinha A; Chen CW; Deshpande AJ; Cusan M; Farnoud N; Mupo A; Grove C; Koche R; Bradner JE; de Stanchina E; Vassiliou GS; Hoshii T; Armstrong SA
    Cancer Discov; 2016 Oct; 6(10):1166-1181. PubMed ID: 27535106
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
    Krivtsov AV; Evans K; Gadrey JY; Eschle BK; Hatton C; Uckelmann HJ; Ross KN; Perner F; Olsen SN; Pritchard T; McDermott L; Jones CD; Jing D; Braytee A; Chacon D; Earley E; McKeever BM; Claremon D; Gifford AJ; Lee HJ; Teicher BA; Pimanda JE; Beck D; Perry JA; Smith MA; McGeehan GM; Lock RB; Armstrong SA
    Cancer Cell; 2019 Dec; 36(6):660-673.e11. PubMed ID: 31821784
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Menin Inhibitors in Acute Myeloid Leukemia-What Does the Future Hold?
    Swaminathan M; Bourgeois W; Armstrong SA; Wang ES
    Cancer J; 2022 Jan-Feb 01; 28(1):62-66. PubMed ID: 35072375
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1.
    Fiskus W; Mill CP; Birdwell C; Davis JA; Das K; Boettcher S; Kadia TM; DiNardo CD; Takahashi K; Loghavi S; Soth MJ; Heffernan T; McGeehan GM; Ruan X; Su X; Vakoc CR; Daver N; Bhalla KN
    Blood Cancer J; 2023 Apr; 13(1):53. PubMed ID: 37055414
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair.
    Ye J; Zha J; Shi Y; Li Y; Yuan D; Chen Q; Lin F; Fang Z; Yu Y; Dai Y; Xu B
    Clin Epigenetics; 2019 Oct; 11(1):137. PubMed ID: 31590682
    [TBL] [Abstract][Full Text] [Related]  

  • 15. HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.
    Zhu G; Luo H; Feng Y; Guryanova OA; Xu J; Chen S; Lai Q; Sharma A; Xu B; Zhao Z; Feng R; Ni H; Claxton D; Guo Y; Mesa RA; Qiu Y; Yang FC; Li W; Nimer SD; Huang S; Xu M
    Nat Commun; 2021 Mar; 12(1):1956. PubMed ID: 33782403
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
    Borkin D; Klossowski S; Pollock J; Miao H; Linhares BM; Kempinska K; Jin Z; Purohit T; Wen B; He M; Sun D; Cierpicki T; Grembecka J
    J Med Chem; 2018 Jun; 61(11):4832-4850. PubMed ID: 29738674
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition.
    Dzama MM; Steiner M; Rausch J; Sasca D; Schönfeld J; Kunz K; Taubert MC; McGeehan GM; Chen CW; Mupo A; Hähnel P; Theobald M; Kindler T; Koche RP; Vassiliou GS; Armstrong SA; Kühn MWM
    Blood; 2020 Nov; 136(21):2442-2456. PubMed ID: 32589720
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of MLL1-menin interaction attenuates renal fibrosis in obstructive nephropathy.
    Zou J; Yu C; Zhang C; Guan Y; Zhang Y; Tolbert E; Zhang W; Zhao T; Bayliss G; Li X; Ye Z; Zhuang S
    FASEB J; 2023 Jan; 37(1):e22712. PubMed ID: 36527439
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth.
    Li X; Yao Y; Wu F; Song Y
    J Hematol Oncol; 2022 Apr; 15(1):41. PubMed ID: 35395864
    [TBL] [Abstract][Full Text] [Related]  

  • 20. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program.
    Xu J; Li L; Xiong J; denDekker A; Ye A; Karatas H; Liu L; Wang H; Qin ZS; Wang S; Dou Y
    Cell Discov; 2016; 2():16008. PubMed ID: 27462455
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.