174 related articles for article (PubMed ID: 36849411)
1. Exploiting the Receptor-Binding Domains of R-Spondin 1 to Target Leucine-Rich Repeat-Containin G-Coupled Protein Receptor 5-Expressing Stem Cells in Ovarian Cancer.
Wong C; Mulero MC; Barth EI; Wang K; Shang X; Tikle S; Rice C; Gately D; Howell SB
J Pharmacol Exp Ther; 2023 May; 385(2):95-105. PubMed ID: 36849411
[TBL] [Abstract][Full Text] [Related]
2. Therapeutic Targeting of Tumor Cells Rich in LGR Stem Cell Receptors.
Yu S; Mulero MC; Chen W; Shang X; Tian S; Watanabe J; Watanabe A; Vorberg T; Wong C; Gately D; Howell SB
Bioconjug Chem; 2021 Feb; 32(2):376-384. PubMed ID: 33492953
[TBL] [Abstract][Full Text] [Related]
3. Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.
Peng WC; de Lau W; Forneris F; Granneman JC; Huch M; Clevers H; Gros P
Cell Rep; 2013 Jun; 3(6):1885-92. PubMed ID: 23809763
[TBL] [Abstract][Full Text] [Related]
4. WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer.
Lee S; Jun J; Kim WJ; Tamayo P; Howell SB
Anticancer Res; 2020 Nov; 40(11):6017-6028. PubMed ID: 33109540
[TBL] [Abstract][Full Text] [Related]
5. The structural basis of R-spondin recognition by LGR5 and RNF43.
Chen PH; Chen X; Lin Z; Fang D; He X
Genes Dev; 2013 Jun; 27(12):1345-50. PubMed ID: 23756651
[TBL] [Abstract][Full Text] [Related]
6. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Gong X; Carmon KS; Lin Q; Thomas A; Yi J; Liu Q
PLoS One; 2012; 7(5):e37137. PubMed ID: 22615920
[TBL] [Abstract][Full Text] [Related]
7. LGR5-Targeted Antibody-Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence.
Gong X; Azhdarinia A; Ghosh SC; Xiong W; An Z; Liu Q; Carmon KS
Mol Cancer Ther; 2016 Jul; 15(7):1580-90. PubMed ID: 27207778
[TBL] [Abstract][Full Text] [Related]
8. Structural basis for R-spondin recognition by LGR4/5/6 receptors.
Wang D; Huang B; Zhang S; Yu X; Wu W; Wang X
Genes Dev; 2013 Jun; 27(12):1339-44. PubMed ID: 23756652
[TBL] [Abstract][Full Text] [Related]
9. Drug Conjugates of Antagonistic R-Spondin 4 Mutant for Simultaneous Targeting of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4/5/6 for Cancer Treatment.
Cui J; Toh Y; Park S; Yu W; Tu J; Wu L; Li L; Jacob J; Pan S; Carmon KS; Liu QJ
J Med Chem; 2021 Sep; 64(17):12572-12581. PubMed ID: 34406767
[TBL] [Abstract][Full Text] [Related]
10. Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway.
Kwon MS; Park BO; Kim HM; Kim S
Mol Cells; 2013 Sep; 36(3):267-72. PubMed ID: 23912594
[TBL] [Abstract][Full Text] [Related]
11. Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines.
Alharbi SA; Ovchinnikov DA; Wolvetang E
World J Gastroenterol; 2021 Apr; 27(15):1578-1594. PubMed ID: 33958845
[TBL] [Abstract][Full Text] [Related]
12. Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
Peng WC; de Lau W; Madoori PK; Forneris F; Granneman JC; Clevers H; Gros P
PLoS One; 2013; 8(12):e83110. PubMed ID: 24349440
[TBL] [Abstract][Full Text] [Related]
13. Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling.
Park S; Cui J; Yu W; Wu L; Carmon KS; Liu QJ
J Biol Chem; 2018 Jun; 293(25):9759-9769. PubMed ID: 29752411
[TBL] [Abstract][Full Text] [Related]
14. Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo.
Ren W; Lewandowski BC; Watson J; Aihara E; Iwatsuki K; Bachmanov AA; Margolskee RF; Jiang P
Proc Natl Acad Sci U S A; 2014 Nov; 111(46):16401-6. PubMed ID: 25368147
[TBL] [Abstract][Full Text] [Related]
15. Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).
Xu JG; Huang C; Yang Z; Jin M; Fu P; Zhang N; Luo J; Li D; Liu M; Zhou Y; Zhu Y
J Biol Chem; 2015 Jan; 290(4):2455-65. PubMed ID: 25480784
[TBL] [Abstract][Full Text] [Related]
16. Non-equivalence of Wnt and R-spondin ligands during Lgr5
Yan KS; Janda CY; Chang J; Zheng GXY; Larkin KA; Luca VC; Chia LA; Mah AT; Han A; Terry JM; Ootani A; Roelf K; Lee M; Yuan J; Li X; Bolen CR; Wilhelmy J; Davies PS; Ueno H; von Furstenberg RJ; Belgrader P; Ziraldo SB; Ordonez H; Henning SJ; Wong MH; Snyder MP; Weissman IL; Hsueh AJ; Mikkelsen TS; Garcia KC; Kuo CJ
Nature; 2017 May; 545(7653):238-242. PubMed ID: 28467820
[TBL] [Abstract][Full Text] [Related]
17. Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1.
Wilhelm F; Simon E; Böger C; Behrens HM; Krüger S; Röcken C
Mol Cancer Res; 2017 Jun; 15(6):776-785. PubMed ID: 28219935
[TBL] [Abstract][Full Text] [Related]
18. HER2-targeted antibody drug conjugates for ovarian cancer therapy.
Jiang J; Dong L; Wang L; Wang L; Zhang J; Chen F; Zhang X; Huang M; Li S; Ma W; Xu Q; Huang C; Fang J; Wang C
Eur J Pharm Sci; 2016 Oct; 93():274-86. PubMed ID: 27509865
[TBL] [Abstract][Full Text] [Related]
19. Generation and characterization of monoclonal antibodies against human LGR6.
Funahashi SI; Suzuki Y; Nakano K; Kawai S; Suzuki M
J Biochem; 2017 Apr; 161(4):361-368. PubMed ID: 28013222
[TBL] [Abstract][Full Text] [Related]
20. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Huch M; Dorrell C; Boj SF; van Es JH; Li VS; van de Wetering M; Sato T; Hamer K; Sasaki N; Finegold MJ; Haft A; Vries RG; Grompe M; Clevers H
Nature; 2013 Feb; 494(7436):247-50. PubMed ID: 23354049
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
