BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 36854124)

  • 1. Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
    Sabo KA; Albekioni E; Caliger D; Coleman NJ; Thornberg E; Avellaneda Matteo D; Komives EA; Silletti S; Sohl CD
    Biochemistry; 2023 Mar; 62(6):1145-1159. PubMed ID: 36854124
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction.
    Peng Y; Zhong C; Huang W; Ding J
    Protein Sci; 2008 Sep; 17(9):1542-54. PubMed ID: 18552125
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.
    Luna LA; Lesecq Z; White KA; Hoang A; Scott DA; Zagnitko O; Bobkov AA; Barber DL; Schiffer JM; Isom DG; Sohl CD
    Biochem J; 2020 Aug; 477(16):2999-3018. PubMed ID: 32729927
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.
    Xu X; Zhao J; Xu Z; Peng B; Huang Q; Arnold E; Ding J
    J Biol Chem; 2004 Aug; 279(32):33946-57. PubMed ID: 15173171
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Platform for Investigating Peptide Biosynthetic Enzymes.
    Habibi Y; Thibodeaux CJ
    J Vis Exp; 2020 May; (159):. PubMed ID: 32420996
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isocitrate binding at two functionally distinct sites in yeast NAD+-specific isocitrate dehydrogenase.
    Lin AP; McAlister-Henn L
    J Biol Chem; 2002 Jun; 277(25):22475-83. PubMed ID: 11953438
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of the soluble form of nicotinamide adenine dinucleotide phosphate-specific isocitrate dehydrogenase from lactating bovine mammary gland: effects of metabolites on activity and structure.
    Farrell HM; Wickham ED; Seery VL; Kumosinski TF
    J Dairy Sci; 1993 Dec; 76(12):3799-811. PubMed ID: 8132888
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Kinetic analysis of NAD(+)-isocitrate dehydrogenase with altered isocitrate binding sites: contribution of IDH1 and IDH2 subunits to regulation and catalysis.
    Cupp JR; McAlister-Henn L
    Biochemistry; 1993 Sep; 32(36):9323-8. PubMed ID: 8369302
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen-Deuterium Exchange Mass Spectrometry.
    Olaleye O; Graf C; Spanov B; Govorukhina N; Groves MR; van de Merbel NC; Bischoff R
    J Am Soc Mass Spectrom; 2023 Apr; 34(4):775-783. PubMed ID: 36960982
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.
    Chambers JM; Miller W; Quichocho G; Upadhye V; Matteo DA; Bobkov AA; Sohl CD; Schiffer JM
    Biochemistry; 2020 Feb; 59(4):479-490. PubMed ID: 31869219
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Basis for half-site ligand binding in yeast NAD(+)-specific isocitrate dehydrogenase.
    Lin AP; McAlister-Henn L
    Biochemistry; 2011 Sep; 50(38):8241-50. PubMed ID: 21861471
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7-A resolution: conformational changes induced by decarboxylation of isocitrate.
    Stoddard BL; Koshland DE
    Biochemistry; 1993 Sep; 32(36):9317-22. PubMed ID: 8369301
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A high-throughput SAMDI-mass spectrometry assay for isocitrate dehydrogenase 1.
    Anderson SE; Fahey NS; Park J; O'Kane PT; Mirkin CA; Mrksich M
    Analyst; 2020 Jun; 145(11):3899-3908. PubMed ID: 32297889
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinetic and physiological effects of alterations in homologous isocitrate-binding sites of yeast NAD(+)-specific isocitrate dehydrogenase.
    Lin AP; McCammon MT; McAlister-Henn L
    Biochemistry; 2001 Nov; 40(47):14291-301. PubMed ID: 11714283
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.
    van Lith SA; Navis AC; Lenting K; Verrijp K; Schepens JT; Hendriks WJ; Schubert NA; Venselaar H; Wevers RA; van Rooij A; Wesseling P; Molenaar RJ; van Noorden CJ; Pusch S; Tops B; Leenders WP
    Sci Rep; 2016 Jul; 6():30486. PubMed ID: 27460417
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Virtual mutagenesis of isocitrate dehydrogenase 1 involved in glioblastoma multiforme.
    Wang MD; Shi YF; Wang H; Wang JL; Ma WB; Wang RZ
    Chin Med J (Engl); 2011 Sep; 124(17):2611-5. PubMed ID: 22040412
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluation by mutagenesis of the roles of His309, His315, and His319 in the coenzyme site of pig heart NADP-dependent isocitrate dehydrogenase.
    Huang YC; Colman RF
    Biochemistry; 2002 Apr; 41(17):5637-43. PubMed ID: 11969425
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluation by site-directed mutagenesis of aspartic acid residues in the metal site of pig heart NADP-dependent isocitrate dehydrogenase.
    Grodsky NB; Soundar S; Colman RF
    Biochemistry; 2000 Mar; 39(9):2193-200. PubMed ID: 10694384
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.
    Avellaneda Matteo D; Grunseth AJ; Gonzalez ER; Anselmo SL; Kennedy MA; Moman P; Scott DA; Hoang A; Sohl CD
    J Biol Chem; 2017 May; 292(19):7971-7983. PubMed ID: 28330869
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase.
    Miyagi M; Wan Q; Ahmad MF; Gokulrangan G; Tomechko SE; Bennett B; Dealwis C
    PLoS One; 2011 Feb; 6(2):e17055. PubMed ID: 21359214
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.