149 related articles for article (PubMed ID: 36876904)
1. Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases.
Lindberg MF; Deau E; Arfwedson J; George N; George P; Alfonso P; Corrionero A; Meijer L
J Med Chem; 2023 Mar; 66(6):4106-4130. PubMed ID: 36876904
[TBL] [Abstract][Full Text] [Related]
2. Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview.
Lindberg MF; Meijer L
Int J Mol Sci; 2021 Jun; 22(11):. PubMed ID: 34205123
[TBL] [Abstract][Full Text] [Related]
3. Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.
Loaëc N; Attanasio E; Villiers B; Durieu E; Tahtouh T; Cam M; Davis RA; Alencar A; Roué M; Bourguet-Kondracki ML; Proksch P; Limanton E; Guiheneuf S; Carreaux F; Bazureau JP; Klautau M; Meijer L
Mar Drugs; 2017 Oct; 15(10):. PubMed ID: 29039762
[TBL] [Abstract][Full Text] [Related]
4. Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.
Deau E; Lindberg MF; Miege F; Roche D; George N; George P; Krämer A; Knapp S; Meijer L
J Med Chem; 2023 Aug; 66(15):10694-10714. PubMed ID: 37487467
[TBL] [Abstract][Full Text] [Related]
5. Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4.
Schmitt C; Miralinaghi P; Mariano M; Hartmann RW; Engel M
ACS Med Chem Lett; 2014 Sep; 5(9):963-7. PubMed ID: 25221649
[TBL] [Abstract][Full Text] [Related]
6. Mechanism of dual specificity kinase activity of DYRK1A.
Walte A; Rüben K; Birner-Gruenberger R; Preisinger C; Bamberg-Lemper S; Hilz N; Bracher F; Becker W
FEBS J; 2013 Sep; 280(18):4495-511. PubMed ID: 23809146
[TBL] [Abstract][Full Text] [Related]
7. Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Coombs TC; Tanega C; Shen M; Wang JL; Auld DS; Gerritz SW; Schoenen FJ; Thomas CJ; Aubé J
Bioorg Med Chem Lett; 2013 Jun; 23(12):3654-61. PubMed ID: 23642479
[TBL] [Abstract][Full Text] [Related]
8. Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core.
Ţînţaş ML; Peauger L; Alix F; Papamicaël C; Besson T; Sopková-de Oliveira Santos J; Gembus V; Levacher V
Molecules; 2022 Dec; 28(1):. PubMed ID: 36615235
[TBL] [Abstract][Full Text] [Related]
9. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice.
Naert G; Ferré V; Meunier J; Keller E; Malmström S; Givalois L; Carreaux F; Bazureau JP; Maurice T
Eur Neuropsychopharmacol; 2015 Nov; 25(11):2170-82. PubMed ID: 26381812
[TBL] [Abstract][Full Text] [Related]
10. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
Walter A; Chaikuad A; Helmer R; Loaëc N; Preu L; Ott I; Knapp S; Meijer L; Kunick C
PLoS One; 2018; 13(5):e0196761. PubMed ID: 29723265
[TBL] [Abstract][Full Text] [Related]
11. Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
Tahtouh T; Durieu E; Villiers B; Bruyère C; Nguyen TL; Fant X; Ahn KH; Khurana L; Deau E; Lindberg MF; Sévère E; Miege F; Roche D; Limanton E; L'Helgoual'ch JM; Burgy G; Guiheneuf S; Herault Y; Kendall DA; Carreaux F; Bazureau JP; Meijer L
J Med Chem; 2022 Jan; 65(2):1396-1417. PubMed ID: 34928152
[TBL] [Abstract][Full Text] [Related]
12. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Tahtouh T; Elkins JM; Filippakopoulos P; Soundararajan M; Burgy G; Durieu E; Cochet C; Schmid RS; Lo DC; Delhommel F; Oberholzer AE; Pearl LH; Carreaux F; Bazureau JP; Knapp S; Meijer L
J Med Chem; 2012 Nov; 55(21):9312-30. PubMed ID: 22998443
[TBL] [Abstract][Full Text] [Related]
13. Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma.
Zhou Q; Phoa AF; Abbassi RH; Hoque M; Reekie TA; Font JS; Ryan RM; Stringer BW; Day BW; Johns TG; Munoz L; Kassiou M
J Med Chem; 2017 Mar; 60(5):2052-2070. PubMed ID: 28206758
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors.
Schmitt C; Kail D; Mariano M; Empting M; Weber N; Paul T; Hartmann RW; Engel M
PLoS One; 2014; 9(3):e87851. PubMed ID: 24676346
[TBL] [Abstract][Full Text] [Related]
15. Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
Czarna A; Wang J; Zelencova D; Liu Y; Deng X; Choi HG; Zhang T; Zhou W; Chang JW; Kildalsen H; Seternes OM; Gray NS; Engh RA; Rothweiler U
J Med Chem; 2018 Sep; 61(17):7560-7572. PubMed ID: 30095246
[TBL] [Abstract][Full Text] [Related]
16. Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.
Brahmaiah D; Kanaka Durga Bhavani A; Aparna P; Sampath Kumar N; Solhi H; Le Guevel R; Baratte B; Ruchaud S; Bach S; Singh Jadav S; Raji Reddy C; Roisnel T; Mosset P; Levoin N; Grée R
Bioorg Med Chem; 2021 Feb; 31():115962. PubMed ID: 33422908
[TBL] [Abstract][Full Text] [Related]
17. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.
Falke H; Chaikuad A; Becker A; Loaëc N; Lozach O; Abu Jhaisha S; Becker W; Jones PG; Preu L; Baumann K; Knapp S; Meijer L; Kunick C
J Med Chem; 2015 Apr; 58(7):3131-43. PubMed ID: 25730262
[TBL] [Abstract][Full Text] [Related]
18. Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity.
Kumar K; Man-Un Ung P; Wang P; Wang H; Li H; Andrews MK; Stewart AF; Schlessinger A; DeVita RJ
Eur J Med Chem; 2018 Sep; 157():1005-1016. PubMed ID: 30170319
[TBL] [Abstract][Full Text] [Related]
19. Structure Activity Relationship Studies around
Brahmaiah D; Bhavani AKD; Aparna P; Kumar NS; Solhi H; Le Guevel R; Baratte B; Robert T; Ruchaud S; Bach S; Jadav SS; Reddy CR; Mosset P; Gouault N; Levoin N; Grée R
Molecules; 2022 Sep; 27(19):. PubMed ID: 36234686
[TBL] [Abstract][Full Text] [Related]
20.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
[Next] [New Search]