250 related articles for article (PubMed ID: 36884303)
1. Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF.
Ibanez V; Vaitkus K; Zhang X; Ramasamy J; Rivers AE; Saunthararajah Y; Molokie R; Lavelle D
Blood Adv; 2023 Aug; 7(15):3891-3902. PubMed ID: 36884303
[TBL] [Abstract][Full Text] [Related]
2. Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons.
Rivers A; Vaitkus K; Jagadeeswaran R; Ruiz MA; Ibanez V; Ciceri F; Cavalcanti F; Molokie RE; Saunthararajah Y; Engel JD; DeSimone J; Lavelle D
Exp Hematol; 2018 Nov; 67():60-64.e2. PubMed ID: 30125603
[TBL] [Abstract][Full Text] [Related]
3. RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model.
Rivers A; Vaitkus K; Ruiz MA; Ibanez V; Jagadeeswaran R; Kouznetsova T; DeSimone J; Lavelle D
Exp Hematol; 2015 Jul; 43(7):546-53.e1-3. PubMed ID: 25931013
[TBL] [Abstract][Full Text] [Related]
4. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).
Rivers A; Vaitkus K; Ibanez V; Ruiz MA; Jagadeeswaran R; Saunthararajah Y; Cui S; Engel JD; DeSimone J; Lavelle D
Haematologica; 2016 Jun; 101(6):688-97. PubMed ID: 26858356
[TBL] [Abstract][Full Text] [Related]
5. Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis).
Ibanez V; Vaitkus K; Ruiz MA; Lei Z; Maienschein-Cline M; Arbieva Z; Lavelle D
PLoS One; 2023; 18(12):e0289860. PubMed ID: 38134183
[TBL] [Abstract][Full Text] [Related]
6. Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
Molokie R; Lavelle D; Gowhari M; Pacini M; Krauz L; Hassan J; Ibanez V; Ruiz MA; Ng KP; Woost P; Radivoyevitch T; Pacelli D; Fada S; Rump M; Hsieh M; Tisdale JF; Jacobberger J; Phelps M; Engel JD; Saraf S; Hsu LL; Gordeuk V; DeSimone J; Saunthararajah Y
PLoS Med; 2017 Sep; 14(9):e1002382. PubMed ID: 28880867
[TBL] [Abstract][Full Text] [Related]
7. Clinical studies with fetal hemoglobin-enhancing agents in sickle cell disease.
Saunthararajah Y; DeSimone J
Semin Hematol; 2004 Oct; 41(4 Suppl 6):11-6. PubMed ID: 15534852
[TBL] [Abstract][Full Text] [Related]
8.
Gilmartin AG; Groy A; Gore ER; Atkins C; Long ER; Montoute MN; Wu Z; Halsey W; McNulty DE; Ennulat D; Rueda L; Pappalardi M; Kruger RG; McCabe MT; Raoof A; Butlin R; Stowell A; Cockerill M; Waddell I; Ogilvie D; Luengo J; Jordan A; Benowitz AB
Haematologica; 2021 Jul; 106(7):1979-1987. PubMed ID: 32586904
[TBL] [Abstract][Full Text] [Related]
9. Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data.
Rivers A; Jagadeeswaran R; Lavelle D
Am J Physiol Regul Integr Comp Physiol; 2018 Oct; 315(4):R840-R847. PubMed ID: 30067082
[TBL] [Abstract][Full Text] [Related]
10. Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea.
Allard P; Alhaj N; Lobitz S; Cario H; Jarisch A; Grosse R; Oevermann L; Hakimeh D; Tagliaferri L; Kohne E; Kopp-Schneider A; Kulozik AE; Kunz JB
Haematologica; 2022 Jul; 107(7):1577-1588. PubMed ID: 34706496
[TBL] [Abstract][Full Text] [Related]
11. Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription.
Akpan I; Banzon V; Ibanez V; Vaitkus K; DeSimone J; Lavelle D
Exp Hematol; 2010 Nov; 38(11):989-993.e1. PubMed ID: 20713129
[TBL] [Abstract][Full Text] [Related]
12. Hemoglobin F (HbF) Inducers; History, Structure and Efficacies.
Hashemi Z; Ebrahimzadeh MA
Mini Rev Med Chem; 2022; 22(1):52-68. PubMed ID: 34036918
[TBL] [Abstract][Full Text] [Related]
13. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.
Krishnamoorthy S; Pace B; Gupta D; Sturtevant S; Li B; Makala L; Brittain J; Moore N; Vieira BF; Thullen T; Stone I; Li H; Hobbs WE; Light DR
JCI Insight; 2017 Oct; 2(20):. PubMed ID: 29046485
[TBL] [Abstract][Full Text] [Related]
14. Post-Transcriptional Genetic Silencing of
Esrick EB; Lehmann LE; Biffi A; Achebe M; Brendel C; Ciuculescu MF; Daley H; MacKinnon B; Morris E; Federico A; Abriss D; Boardman K; Khelladi R; Shaw K; Negre H; Negre O; Nikiforow S; Ritz J; Pai SY; London WB; Dansereau C; Heeney MM; Armant M; Manis JP; Williams DA
N Engl J Med; 2021 Jan; 384(3):205-215. PubMed ID: 33283990
[TBL] [Abstract][Full Text] [Related]
15. 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia.
Koshy M; Dorn L; Bressler L; Molokie R; Lavelle D; Talischy N; Hoffman R; van Overveld W; DeSimone J
Blood; 2000 Oct; 96(7):2379-84. PubMed ID: 11001887
[TBL] [Abstract][Full Text] [Related]
16. Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease.
Saunthararajah Y; Hillery CA; Lavelle D; Molokie R; Dorn L; Bressler L; Gavazova S; Chen YH; Hoffman R; DeSimone J
Blood; 2003 Dec; 102(12):3865-70. PubMed ID: 12907443
[TBL] [Abstract][Full Text] [Related]
17. Novel histone deacetylase inhibitor CT-101 induces γ-globin gene expression in sickle erythroid progenitors with targeted epigenetic effects.
Junker LH; Li B; Zhu X; Koti S; Cerbone RE; Hendrick CL; Sangerman J; Perrine S; Pace BS
Blood Cells Mol Dis; 2022 Mar; 93():102626. PubMed ID: 34856533
[TBL] [Abstract][Full Text] [Related]
18. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.
Zhang Y; Paikari A; Sumazin P; Ginter Summarell CC; Crosby JR; Boerwinkle E; Weiss MJ; Sheehan VA
Blood; 2018 Jul; 132(3):321-333. PubMed ID: 29884740
[TBL] [Abstract][Full Text] [Related]
19. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.
Cui S; Lim KC; Shi L; Lee M; Jearawiriyapaisarn N; Myers G; Campbell A; Harro D; Iwase S; Trievel RC; Rivers A; DeSimone J; Lavelle D; Saunthararajah Y; Engel JD
Blood; 2015 Jul; 126(3):386-96. PubMed ID: 26031919
[TBL] [Abstract][Full Text] [Related]
20. Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice.
Oseghale AR; Zhu X; Li B; Peterson KR; Nudelman A; Rephaeli A; Xu H; Pace BS
Blood Cells Mol Dis; 2019 Nov; 79():102345. PubMed ID: 31351219
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]