144 related articles for article (PubMed ID: 36898968)
1. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.
Teng M; Jiang J; Wang ES; Geng Q; Toenjes ST; Donovan KA; Mageed N; Yue H; Nowak RP; Wang J; Manz TD; Fischer ES; Cantley LC; Gray NS
Angew Chem Int Ed Engl; 2023 Apr; 62(18):e202302364. PubMed ID: 36898968
[TBL] [Abstract][Full Text] [Related]
2. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
Shim H; Wu C; Ramsamooj S; Bosch KN; Chen Z; Emerling BM; Yun J; Liu H; Choo-Wing R; Yang Z; Wulf GM; Kuchroo VK; Cantley LC
Proc Natl Acad Sci U S A; 2016 Jul; 113(27):7596-601. PubMed ID: 27313209
[TBL] [Abstract][Full Text] [Related]
3. PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells.
Roy A; Chakraborty AR; Nomanbhoy T; DePamphilis ML
Autophagy; 2023 Sep; 19(9):2464-2484. PubMed ID: 36803256
[TBL] [Abstract][Full Text] [Related]
4. Development of potent and selective degraders of PI5P4Kγ.
Ji W; Wang ES; Manz TD; Jiang J; Donovan KA; Abulaiti X; Fischer ES; Cantley LC; Zhang T; Gray NS
Eur J Med Chem; 2023 Feb; 247():115027. PubMed ID: 36584631
[TBL] [Abstract][Full Text] [Related]
5. PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Karim M; Mishra M; Lo CW; Saul S; Cagirici HB; Tran DHN; Agrawal A; Ghita L; Ojha A; East MP; Gammeltoft KA; Sahoo MK; Johnson GL; Das S; Jochmans D; Cohen CA; Gottwein J; Dye J; Neff N; Pinsky BA; Laitinen T; Pantsar T; Poso A; Zanini F; Jonghe S; Asquith CRM; Einav S
bioRxiv; 2024 Apr; ():. PubMed ID: 38659941
[TBL] [Abstract][Full Text] [Related]
6. PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.
Lima K; Coelho-Silva JL; Kinker GS; Pereira-Martins DA; Traina F; Fernandes PACM; Markus RP; Lucena-Araujo AR; Machado-Neto JA
Cancer Genet; 2019 Apr; 233-234():56-66. PubMed ID: 31109595
[TBL] [Abstract][Full Text] [Related]
7. Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.
Magadum A; Singh N; Kurian AA; Sharkar MTK; Sultana N; Chepurko E; Kaur K; Żak MM; Hadas Y; Lebeche D; Sahoo S; Hajjar R; Zangi L
Adv Sci (Weinh); 2021 May; 8(10):2004661. PubMed ID: 34026458
[TBL] [Abstract][Full Text] [Related]
8. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis.
Sharma G; Guardia CM; Roy A; Vassilev A; Saric A; Griner LN; Marugan J; Ferrer M; Bonifacino JS; DePamphilis ML
Autophagy; 2019 Oct; 15(10):1694-1718. PubMed ID: 30806145
[TBL] [Abstract][Full Text] [Related]
9. Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
Cao X; Lenk GM; Meisler MH
G3 (Bethesda); 2023 Aug; 13(8):. PubMed ID: 36691351
[TBL] [Abstract][Full Text] [Related]
10. C24-Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation.
Zhang Y; Wang H; Chen T; Wang H; Liang X; Zhang Y; Duan J; Qian S; Qiao K; Zhang L; Liu Y; Wang J
Hepatology; 2021 Feb; 73(2):692-712. PubMed ID: 32374916
[TBL] [Abstract][Full Text] [Related]
11. Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor.
Kato JY; Korenaga S; Iwakura M
Bioorg Med Chem Lett; 2023 Jan; 79():129083. PubMed ID: 36414177
[TBL] [Abstract][Full Text] [Related]
12. Development of CDK2 and CDK5 Dual Degrader TMX-2172.
Teng M; Jiang J; He Z; Kwiatkowski NP; Donovan KA; Mills CE; Victor C; Hatcher JM; Fischer ES; Sorger PK; Zhang T; Gray NS
Angew Chem Int Ed Engl; 2020 Aug; 59(33):13865-13870. PubMed ID: 32415712
[TBL] [Abstract][Full Text] [Related]
13. Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma.
Giudici ML; Clarke JH; Irvine RF
Adv Biol Regul; 2016 May; 61():47-50. PubMed ID: 26710750
[TBL] [Abstract][Full Text] [Related]
14. Degradation of lipid droplets by chimeric autophagy-tethering compounds.
Fu Y; Chen N; Wang Z; Luo S; Ding Y; Lu B
Cell Res; 2021 Sep; 31(9):965-979. PubMed ID: 34239073
[TBL] [Abstract][Full Text] [Related]
15. Targeting lipid droplets for autophagic degradation by ATTEC.
Fu Y; Lu B
Autophagy; 2021 Dec; 17(12):4486-4488. PubMed ID: 34436975
[TBL] [Abstract][Full Text] [Related]
16. WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway-Mowat Syndrome.
Li H; Liu F; Kuang H; Teng H; Chen S; Zeng S; Zhou Q; Li Z; Liang D; Li Z; Wu L
Biology (Basel); 2022 Sep; 11(10):. PubMed ID: 36290302
[TBL] [Abstract][Full Text] [Related]
17. Novel Mechanism for an Old Drug: Phenazopyridine is a Kinase Inhibitor Affecting Autophagy and Cellular Differentiation.
Preynat-Seauve O; Nguyen EB; Westermaier Y; Héritier M; Tardy S; Cambet Y; Feyeux M; Caillon A; Scapozza L; Krause KH
Front Pharmacol; 2021; 12():664608. PubMed ID: 34421588
[TBL] [Abstract][Full Text] [Related]
18. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.
Donovan KA; Ferguson FM; Bushman JW; Eleuteri NA; Bhunia D; Ryu S; Tan L; Shi K; Yue H; Liu X; Dobrovolsky D; Jiang B; Wang J; Hao M; You I; Teng M; Liang Y; Hatcher J; Li Z; Manz TD; Groendyke B; Hu W; Nam Y; Sengupta S; Cho H; Shin I; Agius MP; Ghobrial IM; Ma MW; Che J; Buhrlage SJ; Sim T; Gray NS; Fischer ES
Cell; 2020 Dec; 183(6):1714-1731.e10. PubMed ID: 33275901
[TBL] [Abstract][Full Text] [Related]
19. Bivalent Ligands for Protein Degradation in Drug Discovery.
Scheepstra M; Hekking KFW; van Hijfte L; Folmer RHA
Comput Struct Biotechnol J; 2019; 17():160-176. PubMed ID: 30788082
[TBL] [Abstract][Full Text] [Related]
20. Discovery and resistance mechanism of a selective CDK12 degrader.
Jiang B; Gao Y; Che J; Lu W; Kaltheuner IH; Dries R; Kalocsay M; Berberich MJ; Jiang J; You I; Kwiatkowski N; Riching KM; Daniels DL; Sorger PK; Geyer M; Zhang T; Gray NS
Nat Chem Biol; 2021 Jun; 17(6):675-683. PubMed ID: 33753926
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
