170 related articles for article (PubMed ID: 36904854)
1. Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells.
Houser MCQ; Mitchell SPC; Sinha P; Lundin B; Berezovska O; Maesako M
Sensors (Basel); 2023 Feb; 23(5):. PubMed ID: 36904854
[TBL] [Abstract][Full Text] [Related]
2. Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons.
Maesako M; Houser MCQ; Turchyna Y; Wolfe MS; Berezovska O
J Neurosci; 2022 Jan; 42(1):145-154. PubMed ID: 34810230
[TBL] [Abstract][Full Text] [Related]
3. In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons.
McKendell AK; Houser MCQ; Mitchell SPC; Wolfe MS; Berezovska O; Maesako M
Biosensors (Basel); 2022 Aug; 12(8):. PubMed ID: 36005059
[TBL] [Abstract][Full Text] [Related]
4. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Czirr E; Cottrell BA; Leuchtenberger S; Kukar T; Ladd TB; Esselmann H; Paul S; Schubenel R; Torpey JW; Pietrzik CU; Golde TE; Wiltfang J; Baumann K; Koo EH; Weggen S
J Biol Chem; 2008 Jun; 283(25):17049-54. PubMed ID: 18426795
[TBL] [Abstract][Full Text] [Related]
5. Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells.
Houser MCQ; Turchyna Y; Perrin F; Chibnik L; Berezovska O; Maesako M
Biosensors (Basel); 2021 May; 11(6):. PubMed ID: 34073182
[TBL] [Abstract][Full Text] [Related]
6. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.
Devkota S; Williams TD; Wolfe MS
J Biol Chem; 2021; 296():100281. PubMed ID: 33450230
[TBL] [Abstract][Full Text] [Related]
7. γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.
Matsumura N; Takami M; Okochi M; Wada-Kakuda S; Fujiwara H; Tagami S; Funamoto S; Ihara Y; Morishima-Kawashima M
J Biol Chem; 2014 Feb; 289(8):5109-21. PubMed ID: 24375443
[TBL] [Abstract][Full Text] [Related]
8. Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.
Sun Z; Xie Y; Chen Y; Yang Q; Quan Z; Dai R; Qing H
Mol Neurobiol; 2018 May; 55(5):3841-3855. PubMed ID: 28547526
[TBL] [Abstract][Full Text] [Related]
9. Effects of membrane lipids on the activity and processivity of purified γ-secretase.
Holmes O; Paturi S; Ye W; Wolfe MS; Selkoe DJ
Biochemistry; 2012 May; 51(17):3565-75. PubMed ID: 22489600
[TBL] [Abstract][Full Text] [Related]
10. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
[TBL] [Abstract][Full Text] [Related]
11. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.
Fernandez MA; Klutkowski JA; Freret T; Wolfe MS
J Biol Chem; 2014 Nov; 289(45):31043-52. PubMed ID: 25239621
[TBL] [Abstract][Full Text] [Related]
12. Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production.
Kanatsu K; Hori Y; Ebinuma I; Chiu YW; Tomita T
J Neurochem; 2018 Oct; 147(1):110-123. PubMed ID: 29851073
[TBL] [Abstract][Full Text] [Related]
13. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
Richter L; Munter LM; Ness J; Hildebrand PW; Dasari M; Unterreitmeier S; Bulic B; Beyermann M; Gust R; Reif B; Weggen S; Langosch D; Multhaup G
Proc Natl Acad Sci U S A; 2010 Aug; 107(33):14597-602. PubMed ID: 20679249
[TBL] [Abstract][Full Text] [Related]
14. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.
Uemura K; Lill CM; Li X; Peters JA; Ivanov A; Fan Z; DeStrooper B; Bacskai BJ; Hyman BT; Berezovska O
PLoS One; 2009 Nov; 4(11):e7893. PubMed ID: 19924286
[TBL] [Abstract][Full Text] [Related]
15. γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.
Ran Y; Cruz PE; Ladd TB; Fauq AH; Jung JI; Matthews J; Felsenstein KM; Golde TE
J Biol Chem; 2014 Feb; 289(6):3276-87. PubMed ID: 24352661
[TBL] [Abstract][Full Text] [Related]
16. Membrane lipid remodeling modulates γ-secretase processivity.
Dawkins E; Derks RJE; Schifferer M; Trambauer J; Winkler E; Simons M; Paquet D; Giera M; Kamp F; Steiner H
J Biol Chem; 2023 Apr; 299(4):103027. PubMed ID: 36805335
[TBL] [Abstract][Full Text] [Related]
17. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.
Vetrivel KS; Cheng H; Lin W; Sakurai T; Li T; Nukina N; Wong PC; Xu H; Thinakaran G
J Biol Chem; 2004 Oct; 279(43):44945-54. PubMed ID: 15322084
[TBL] [Abstract][Full Text] [Related]
18. Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.
Higashide H; Ishihara S; Nobuhara M; Ihara Y; Funamoto S
J Neurochem; 2017 Mar; 140(6):955-962. PubMed ID: 28032911
[TBL] [Abstract][Full Text] [Related]
19. The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
Wanngren J; Frånberg J; Svensson AI; Laudon H; Olsson F; Winblad B; Liu F; Näslund J; Lundkvist J; Karlström H
J Biol Chem; 2010 Mar; 285(12):8527-36. PubMed ID: 20106965
[TBL] [Abstract][Full Text] [Related]
20. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
Jung JI; Ran Y; Cruz PE; Rosario AM; Ladd TB; Kukar TL; Koo EH; Felsenstein KM; Golde TE
Biochemistry; 2014 Apr; 53(12):1947-57. PubMed ID: 24620716
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
