BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

275 related articles for article (PubMed ID: 36944398)

  • 21. Are γ-secretase and its associated Alzheimer's disease γ problems?
    Rodríguez-Manotas M; Amorín-Díaz M; Cabezas-Herrera J; Acedo-Martínez A; Llorca-Escuín I
    Med Hypotheses; 2012 Feb; 78(2):299-304. PubMed ID: 22133557
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
    Marinangeli C; Tasiaux B; Opsomer R; Hage S; Sodero AO; Dewachter I; Octave JN; Smith SO; Constantinescu SN; Kienlen-Campard P
    J Biol Chem; 2015 Mar; 290(11):7169-84. PubMed ID: 25614624
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.
    Pérez-Revuelta BI; Fukumori A; Lammich S; Yamasaki A; Haass C; Steiner H
    J Neurochem; 2010 Feb; 112(4):940-50. PubMed ID: 20021564
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.
    Ryazantseva M; Skobeleva K; Glushankova L; Kaznacheyeva E
    J Neurochem; 2016 Mar; 136(5):1085-95. PubMed ID: 26678016
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
    Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
    Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
    [TBL] [Abstract][Full Text] [Related]  

  • 27. γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.
    Hedskog L; Petersen CA; Svensson AI; Welander H; Tjernberg LO; Karlström H; Ankarcrona M
    J Cell Mol Med; 2011 Oct; 15(10):2150-63. PubMed ID: 21054783
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
    Gong P; Vetrivel KS; Nguyen PD; Meckler X; Cheng H; Kounnas MZ; Wagner SL; Parent AT; Thinakaran G
    J Biol Chem; 2010 Dec; 285(49):38042-52. PubMed ID: 20921220
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
    Wu S; Song W; Wong CCL; Shi Y
    Proc Natl Acad Sci U S A; 2019 Jan; 116(1):141-147. PubMed ID: 30559186
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W
    Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
    Feilen LP; Chen SY; Fukumori A; Feederle R; Zacharias M; Steiner H
    Elife; 2022 May; 11():. PubMed ID: 35579427
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
    Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
    J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Bidirectional regulation of Aβ levels by Presenilin 1.
    Bustos V; Pulina MV; Kelahmetoglu Y; Sinha SC; Gorelick FS; Flajolet M; Greengard P
    Proc Natl Acad Sci U S A; 2017 Jul; 114(27):7142-7147. PubMed ID: 28533411
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.
    Fernandez MA; Klutkowski JA; Freret T; Wolfe MS
    J Biol Chem; 2014 Nov; 289(45):31043-52. PubMed ID: 25239621
    [TBL] [Abstract][Full Text] [Related]  

  • 35. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.
    Wang J; Lu R; Yang J; Li H; He Z; Jing N; Wang X; Wang Y
    Nat Commun; 2015 Nov; 6():8876. PubMed ID: 26581893
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
    Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
    eNeuro; 2021; 8(2):. PubMed ID: 33608391
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.
    Tominaga A; Cai T; Takagi-Niidome S; Iwatsubo T; Tomita T
    J Neurosci; 2016 Jan; 36(4):1362-72. PubMed ID: 26818522
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.
    Zoltowska KM; Berezovska O
    Mol Neurobiol; 2018 Mar; 55(3):2275-2284. PubMed ID: 28332150
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation.
    Cai T; Tomita T
    J Biochem; 2021 Oct; 170(2):215-227. PubMed ID: 33739423
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
    Kretner B; Fukumori A; Kuhn PH; Pérez-Revuelta BI; Lichtenthaler SF; Haass C; Steiner H
    J Neurochem; 2013 Apr; 125(1):144-56. PubMed ID: 23237322
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.