BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 36958722)

  • 1. Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6.
    Qian L; Scott NA; Capell-Hattam IM; Draper EA; Fenton NM; Luu W; Sharpe LJ; Brown AJ
    J Lipid Res; 2023 May; 64(5):100362. PubMed ID: 36958722
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A paREDOX in the control of cholesterol biosynthesis: Does the NADPH sensor and E3 ubiquitin ligase MARCHF6 protect mammalian cells during oxidative stress by controlling sterol biosynthesis?
    Fenton NM; Qian L; Paine EG; Sharpe LJ; Brown AJ
    Bioessays; 2024 May; ():e2400073. PubMed ID: 38760877
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond.
    Scott NA; Sharpe LJ; Brown AJ
    Biochim Biophys Acta Mol Cell Biol Lipids; 2021 Jan; 1866(1):158837. PubMed ID: 33049405
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
    Scott NA; Sharpe LJ; Capell-Hattam IM; Gullo SJ; Luu W; Brown AJ
    Biochem J; 2020 Jan; 477(2):541-555. PubMed ID: 31904814
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
    Sukhanova A; Gorin A; Serebriiskii IG; Gabitova L; Zheng H; Restifo D; Egleston BL; Cunningham D; Bagnyukova T; Liu H; Nikonova A; Adams GP; Zhou Y; Yang DH; Mehra R; Burtness B; Cai KQ; Klein-Szanto A; Kratz LE; Kelley RI; Weiner LM; Herman GE; Golemis EA; Astsaturov I
    Cancer Discov; 2013 Jan; 3(1):96-111. PubMed ID: 23125191
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis.
    Nguyen KT; Mun SH; Yang J; Lee J; Seok OH; Kim E; Kim D; An SY; Seo DY; Suh JY; Lee Y; Hwang CS
    Nat Cell Biol; 2022 Aug; 24(8):1239-1251. PubMed ID: 35941365
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.
    Ohashi M; Mizushima N; Kabeya Y; Yoshimori T
    J Biol Chem; 2003 Sep; 278(38):36819-29. PubMed ID: 12837764
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6.
    Fenton NM; Qian L; Scott NA; Paine EG; Sharpe LJ; Brown AJ
    Biochim Biophys Acta Mol Cell Biol Lipids; 2024 May; 1869(4):159482. PubMed ID: 38508300
    [No Abstract]   [Full Text] [Related]  

  • 9. Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.
    Capell-Hattam IM; Sharpe LJ; Qian L; Hart-Smith G; Prabhu AV; Brown AJ
    J Biol Chem; 2020 Feb; 295(9):2850-2865. PubMed ID: 31911440
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation.
    Pleshinger MJ; Friedrich RM; Hubler Z; Rivera-León AM; Gao F; Yan D; Sax JL; Srinivasan R; Bederman I; Shick HE; Tesar PJ; Adams DJ
    RSC Chem Biol; 2022 Jan; 3(1):56-68. PubMed ID: 35128409
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally.
    Capell-Hattam IM; Fenton NM; Coates HW; Sharpe LJ; Brown AJ
    J Lipid Res; 2022 Dec; 63(12):100295. PubMed ID: 36216146
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A rare case of sterol-C4-methyl oxidase deficiency in a young Italian male: Biochemical and molecular characterization.
    Frisso G; Gelzo M; Procopio E; Sica C; Lenza MP; Dello Russo A; Donati MA; Salvatore F; Corso G
    Mol Genet Metab; 2017 Aug; 121(4):329-335. PubMed ID: 28673550
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The role of sterol-C4-methyl oxidase in epidermal biology.
    He M; Smith LD; Chang R; Li X; Vockley J
    Biochim Biophys Acta; 2014 Mar; 1841(3):331-5. PubMed ID: 24144731
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.
    Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ
    Elife; 2023 Jan; 12():. PubMed ID: 36655986
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation.
    Sharpe LJ; Howe V; Scott NA; Luu W; Phan L; Berk JM; Hochstrasser M; Brown AJ
    J Biol Chem; 2019 Feb; 294(7):2436-2448. PubMed ID: 30545937
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
    Jo Y; Lee PC; Sguigna PV; DeBose-Boyd RA
    Proc Natl Acad Sci U S A; 2011 Dec; 108(51):20503-8. PubMed ID: 22143767
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis.
    Dickson AS; Pauzaite T; Arnaiz E; Ortmann BM; West JA; Volkmar N; Martinelli AW; Li Z; Wit N; Vitkup D; Kaser A; Lehner PJ; Nathan JA
    Nat Commun; 2023 Aug; 14(1):4816. PubMed ID: 37558666
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.
    Aleidi SM; Howe V; Sharpe LJ; Yang A; Rao G; Brown AJ; Gelissen IC
    J Biol Chem; 2015 Oct; 290(40):24604-13. PubMed ID: 26296893
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
    Song BL; Sever N; DeBose-Boyd RA
    Mol Cell; 2005 Sep; 19(6):829-40. PubMed ID: 16168377
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Noncholesterol sterols.
    Vecka M; Zak A; Tvrzická E
    Acta Univ Carol Med Monogr; 2008; 154():5-101. PubMed ID: 19283968
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.