BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

113 related articles for article (PubMed ID: 36959108)

  • 21. The retinoid derivant ECPIRM selectively exhibited anti-proliferation effects in cutaneous T-Cell lymphoma via ITK-mediated signaling pathway.
    Li H; Wang C; Ma P; Zhang M; Yang H; Yuan S; Wei J; Tao L; Qian K; Xu M; Li L
    J Dermatol Sci; 2020 Mar; 97(3):208-215. PubMed ID: 32165081
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment.
    Shan X; Wange RL
    J Biol Chem; 1999 Oct; 274(41):29323-30. PubMed ID: 10506192
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders.
    Chen L; Chen Y; Zhang C; Jiao B; Liang S; Tan Q; Chai H; Yu W; Qian Y; Yang H; Yao W; Yu J; Luo Y; Plewe M; Wang J; Han XR; Liu J
    J Med Chem; 2020 Dec; 63(23):14562-14575. PubMed ID: 33058680
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.
    Harling JD; Deakin AM; Campos S; Grimley R; Chaudry L; Nye C; Polyakova O; Bessant CM; Barton N; Somers D; Barrett J; Graves RH; Hanns L; Kerr WJ; Solari R
    J Biol Chem; 2013 Sep; 288(39):28195-206. PubMed ID: 23935099
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Optimisation of ITK inhibitors through successive iterative design cycles.
    Herdemann M; Weber A; Jonveaux J; Schwoebel F; Stoeck M; Heit I
    Bioorg Med Chem Lett; 2011 Mar; 21(6):1852-6. PubMed ID: 21316219
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
    Das J; Furch JA; Liu C; Moquin RV; Lin J; Spergel SH; McIntyre KW; Shuster DJ; O'Day KD; Penhallow B; Hung CY; Doweyko AM; Kamath A; Zhang H; Marathe P; Kanner SB; Lin TA; Dodd JH; Barrish JC; Wityak J
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3706-12. PubMed ID: 16682193
    [TBL] [Abstract][Full Text] [Related]  

  • 27. [Effect of Itk down regulation on cytokines production in Jurkat cell].
    Yao HL; He F; Xiao ZH; Han JS; Zhang YD; Huang BY; Liu ZW
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 2010 Oct; 24(5):358-61. PubMed ID: 21280324
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor.
    Grasis JA; Browne CD; Tsoukas CD
    J Immunol; 2003 Apr; 170(8):3971-6. PubMed ID: 12682224
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors.
    Charrier JD; Miller A; Kay DP; Brenchley G; Twin HC; Collier PN; Ramaya S; Keily SB; Durrant SJ; Knegtel RM; Tanner AJ; Brown K; Curnock AP; Jimenez JM
    J Med Chem; 2011 Apr; 54(7):2341-50. PubMed ID: 21391610
    [TBL] [Abstract][Full Text] [Related]  

  • 30. A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation.
    Mamontov P; Eberwine RA; Perrigoue J; Das A; Friedman JR; Mora JR
    PLoS One; 2019; 14(4):e0215963. PubMed ID: 31022269
    [TBL] [Abstract][Full Text] [Related]  

  • 31. 5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).
    Winters MP; Robinson DJ; Khine HH; Pullen SS; Woska JR; Raymond EL; Sellati R; Cywin CL; Snow RJ; Kashem MA; Wolak JP; King J; Kaplita PV; Liu LH; Farrell TM; DesJarlais R; Roth GP; Takahashi H; Moriarty KJ
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5541-4. PubMed ID: 18823779
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.
    Deakin A; Duddy G; Wilson S; Harrison S; Latcham J; Fulleylove M; Fung S; Smith J; Pedrick M; McKevitt T; Felton L; Morley J; Quint D; Fattah D; Hayes B; Gough J; Solari R
    PLoS One; 2014; 9(9):e107490. PubMed ID: 25250764
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.
    Carrizosa E; Gomez TS; Labno CM; Klos Dehring DA; Liu X; Freedman BD; Billadeau DD; Burkhardt JK
    J Immunol; 2009 Dec; 183(11):7352-61. PubMed ID: 19917685
    [TBL] [Abstract][Full Text] [Related]  

  • 34. TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain.
    Ching KA; Grasis JA; Tailor P; Kawakami Y; Kawakami T; Tsoukas CD
    J Immunol; 2000 Jul; 165(1):256-62. PubMed ID: 10861059
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
    Huang HT; Dobrovolsky D; Paulk J; Yang G; Weisberg EL; Doctor ZM; Buckley DL; Cho JH; Ko E; Jang J; Shi K; Choi HG; Griffin JD; Li Y; Treon SP; Fischer ES; Bradner JE; Tan L; Gray NS
    Cell Chem Biol; 2018 Jan; 25(1):88-99.e6. PubMed ID: 29129717
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads.
    Hallumi E; Shalah R; Lo WL; Corso J; Oz I; Beach D; Wittman S; Isenberg A; Sela M; Urlaub H; Weiss A; Yablonski D
    J Immunol; 2021 May; 206(10):2322-2337. PubMed ID: 33931484
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells.
    Eken A; Cansever M; Somekh I; Mizoguchi Y; Zietara N; Okus FZ; Erdem S; Canatan H; Akyol S; Ozcan A; Karakukcu M; Hollizeck S; Rohlfs M; Unal E; Klein C; Patiroglu T
    J Clin Immunol; 2019 May; 39(4):391-400. PubMed ID: 31025232
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease.
    Dierks C; Adrian F; Fisch P; Ma H; Maurer H; Herchenbach D; Forster CU; Sprissler C; Liu G; Rottmann S; Guo GR; Katja Z; Veelken H; Warmuth M
    Cancer Res; 2010 Aug; 70(15):6193-204. PubMed ID: 20670954
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay.
    Zapf CW; Gerstenberger BS; Xing L; Limburg DC; Anderson DR; Caspers N; Han S; Aulabaugh A; Kurumbail R; Shakya S; Li X; Spaulding V; Czerwinski RM; Seth N; Medley QG
    J Med Chem; 2012 Nov; 55(22):10047-63. PubMed ID: 23098091
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
    Gibson S; Truitt K; Lu Y; Lapushin R; Khan H; Imboden JB; Mills GB
    Biochem J; 1998 Mar; 330 ( Pt 3)(Pt 3):1123-8. PubMed ID: 9494076
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.