230 related articles for article (PubMed ID: 36976649)
1. POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling.
Oh G; Wang A; Wang L; Li J; Werba G; Weissinger D; Zhao E; Dhara S; Hernandez RE; Ackermann A; Porcella S; Kalfakakou D; Dolgalev I; Kawaler E; Golan T; Welling TH; Sfeir A; Simeone DM
J Clin Invest; 2023 Jun; 133(11):. PubMed ID: 36976649
[TBL] [Abstract][Full Text] [Related]
2. Polymerase θ inhibition steps on the cGAS pedal.
Smith CM; Gupta GP
J Clin Invest; 2023 Jun; 133(11):. PubMed ID: 37259920
[TBL] [Abstract][Full Text] [Related]
3. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Ceccaldi R; Liu JC; Amunugama R; Hajdu I; Primack B; Petalcorin MI; O'Connor KW; Konstantinopoulos PA; Elledge SJ; Boulton SJ; Yusufzai T; D'Andrea AD
Nature; 2015 Feb; 518(7538):258-62. PubMed ID: 25642963
[TBL] [Abstract][Full Text] [Related]
4. Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer.
Patterson-Fortin J; Jadhav H; Pantelidou C; Phan T; Grochala C; Mehta AK; Guerriero JL; Wulf GM; Wolpin BM; Stanger BZ; Aguirre AJ; Cleary JM; D'Andrea AD; Shapiro GI
Nat Commun; 2023 Mar; 14(1):1390. PubMed ID: 36914658
[TBL] [Abstract][Full Text] [Related]
5. Simultaneous Delivery of Dual Inhibitors of DNA Damage Repair Sensitizes Pancreatic Cancer Response to Irreversible Electroporation.
Long X; Dai A; Huang T; Niu W; Liu L; Xu H; Yin T; Jiang T; Sun S; Lei P; Li C; Zhu X; Zhao J
ACS Nano; 2023 Jul; 17(13):12915-12932. PubMed ID: 37352467
[TBL] [Abstract][Full Text] [Related]
6. POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.
Belan O; Sebald M; Adamowicz M; Anand R; Vancevska A; Neves J; Grinkevich V; Hewitt G; Segura-Bayona S; Bellelli R; Robinson HMR; Higgins GS; Smith GCM; West SC; Rueda DS; Boulton SJ
Mol Cell; 2022 Dec; 82(24):4664-4680.e9. PubMed ID: 36455556
[TBL] [Abstract][Full Text] [Related]
7. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Liu H; Zhang H; Wu X; Ma D; Wu J; Wang L; Jiang Y; Fei Y; Zhu C; Tan R; Jungblut P; Pei G; Dorhoi A; Yan Q; Zhang F; Zheng R; Liu S; Liang H; Liu Z; Yang H; Chen J; Wang P; Tang T; Peng W; Hu Z; Xu Z; Huang X; Wang J; Li H; Zhou Y; Liu F; Yan D; Kaufmann SHE; Chen C; Mao Z; Ge B
Nature; 2018 Nov; 563(7729):131-136. PubMed ID: 30356214
[TBL] [Abstract][Full Text] [Related]
8. Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells.
Sullivan-Reed K; Toma MM; Drzewiecka M; Nieborowska-Skorska M; Nejati R; Karami A; Wasik MA; Sliwinski T; Skorski T
Mol Cancer Res; 2023 Oct; 21(10):1017-1022. PubMed ID: 37358557
[TBL] [Abstract][Full Text] [Related]
9. Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.
Kelso AA; Lopezcolorado FW; Bhargava R; Stark JM
PLoS Genet; 2019 Aug; 15(8):e1008319. PubMed ID: 31381562
[TBL] [Abstract][Full Text] [Related]
10. Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy.
Schrempf A; Slyskova J; Loizou JI
Trends Cancer; 2021 Feb; 7(2):98-111. PubMed ID: 33109489
[TBL] [Abstract][Full Text] [Related]
11. Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
Gout J; Perkhofer L; Morawe M; Arnold F; Ihle M; Biber S; Lange S; Roger E; Kraus JM; Stifter K; Hahn SA; Zamperone A; Engleitner T; Müller M; Walter K; Rodriguez-Aznar E; Sainz B; Hermann PC; Hessmann E; Müller S; Azoitei N; Lechel A; Liebau S; Wagner M; Simeone DM; Kestler HA; Seufferlein T; Wiesmüller L; Rad R; Frappart PO; Kleger A
Gut; 2021 Apr; 70(4):743-760. PubMed ID: 32873698
[TBL] [Abstract][Full Text] [Related]
12. Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair.
Zahn KE; Jensen RB
Genes (Basel); 2021 Aug; 12(9):. PubMed ID: 34573292
[TBL] [Abstract][Full Text] [Related]
13. Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression and T-lymphocyte infiltration in HCC through cGAS-STING pathway.
Ma H; Kang Z; Foo TK; Shen Z; Xia B
Hepatology; 2023 Jan; 77(1):33-47. PubMed ID: 35006619
[TBL] [Abstract][Full Text] [Related]
14. RHINO directs MMEJ to repair DNA breaks in mitosis.
Brambati A; Sacco O; Porcella S; Heyza J; Kareh M; Schmidt JC; Sfeir A
Science; 2023 Aug; 381(6658):653-660. PubMed ID: 37440612
[TBL] [Abstract][Full Text] [Related]
15. Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition-mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2-deficient cancer cells.
Schoonen PM; Kok YP; Wierenga E; Bakker B; Foijer F; Spierings DCJ; van Vugt MATM
Mol Oncol; 2019 Nov; 13(11):2422-2440. PubMed ID: 31529615
[TBL] [Abstract][Full Text] [Related]
16. cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer.
Kabashima A; Matsuo Y; Ito S; Akiyama Y; Ishii T; Shimada S; Masamune A; Tanabe M; Tanaka S
Sci Rep; 2022 Jun; 12(1):10466. PubMed ID: 35773436
[TBL] [Abstract][Full Text] [Related]
17. Targeting Polymerase Theta (POLθ) for Cancer Therapy.
Patterson-Fortin J; D'Andrea AD
Cancer Treat Res; 2023; 186():285-298. PubMed ID: 37978141
[TBL] [Abstract][Full Text] [Related]
18. DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
Wang Z; Song Y; Li S; Kurian S; Xiang R; Chiba T; Wu X
J Biol Chem; 2019 Mar; 294(11):3909-3919. PubMed ID: 30655289
[TBL] [Abstract][Full Text] [Related]
19. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
Mengwasser KE; Adeyemi RO; Leng Y; Choi MY; Clairmont C; D'Andrea AD; Elledge SJ
Mol Cell; 2019 Mar; 73(5):885-899.e6. PubMed ID: 30686591
[TBL] [Abstract][Full Text] [Related]
20. MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways.
Estrada-Bernal A; Chatterjee M; Haque SJ; Yang L; Morgan MA; Kotian S; Morrell D; Chakravarti A; Williams TM
Cell Cycle; 2015; 14(23):3713-24. PubMed ID: 26505547
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]