BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 36993747)

  • 1. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control.
    Wible DJ; Parikh Z; Cho EJ; Chen MD; Mukhopadhyay S; Dalby KN; Varadarajan S; Bratton SB
    bioRxiv; 2023 Mar; ():. PubMed ID: 36993747
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control.
    Wible DJ; Parikh Z; Cho EJ; Chen MD; Jeter CR; Mukhopadhyay S; Dalby KN; Varadarajan S; Bratton SB
    Cell Death Dis; 2024 Jan; 15(1):80. PubMed ID: 38253602
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
    Compton LM; Ikonomov OC; Sbrissa D; Garg P; Shisheva A
    Am J Physiol Cell Physiol; 2016 Sep; 311(3):C366-77. PubMed ID: 27335171
    [TBL] [Abstract][Full Text] [Related]  

  • 4. SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition.
    Menon MB; Kotlyarov A; Gaestel M
    PLoS One; 2011; 6(8):e23054. PubMed ID: 21853067
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.
    Ikonomov OC; Sbrissa D; Venkatareddy M; Tisdale E; Garg P; Shisheva A
    Biochim Biophys Acta; 2015 May; 1853(5):1240-50. PubMed ID: 25619930
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation.
    Ikonomov OC; Altankov G; Sbrissa D; Shisheva A
    Toxicol Appl Pharmacol; 2018 Oct; 356():151-158. PubMed ID: 30098992
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
    Saffi GT; Wang CA; Mangialardi EM; Vacher J; Botelho RJ; Salmena L
    J Biol Chem; 2022 Aug; 298(8):102187. PubMed ID: 35760104
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells.
    Venkatareddy M; Verma R; Kalinowski A; Patel SR; Shisheva A; Garg P
    J Am Soc Nephrol; 2016 Sep; 27(9):2702-19. PubMed ID: 26825532
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation.
    Sbrissa D; Naisan G; Ikonomov OC; Shisheva A
    PLoS One; 2018; 13(9):e0204532. PubMed ID: 30240452
    [TBL] [Abstract][Full Text] [Related]  

  • 10. PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells.
    Roy A; Chakraborty AR; Nomanbhoy T; DePamphilis ML
    Autophagy; 2023 Sep; 19(9):2464-2484. PubMed ID: 36803256
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
    Sbrissa D; Ikonomov OC; Filios C; Delvecchio K; Shisheva A
    Am J Physiol Cell Physiol; 2012 Aug; 303(4):C436-46. PubMed ID: 22621786
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Akebia saponin E, as a novel PIKfyve inhibitor, induces lysosome-associated cytoplasmic vacuolation to inhibit proliferation of hepatocellular carcinoma cells.
    Peng P; Jia D; Cao L; Lu W; Liu X; Liang C; Pan Z; Fang Z
    J Ethnopharmacol; 2021 Feb; 266():113446. PubMed ID: 33031902
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.
    Kayali AG; Austin DA; Webster NJ
    Diabetes; 2000 Nov; 49(11):1783-93. PubMed ID: 11078444
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Lysosomal Storage Disorder Due to
    Bao W; Wang X; Luo L; Ni R
    Zebrafish; 2021 Jun; 18(3):175-183. PubMed ID: 33909505
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel.
    Isobe Y; Nigorikawa K; Tsurumi G; Takemasu S; Takasuga S; Kofuji S; Hazeki K
    J Biochem; 2019 Jan; 165(1):75-84. PubMed ID: 30295876
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA toxin.
    Ikonomov OC; Sbrissa D; Yoshimori T; Cover TL; Shisheva A
    J Biol Chem; 2002 Nov; 277(48):46785-90. PubMed ID: 12213828
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PIKfyve regulation of endosome-linked pathways.
    de Lartigue J; Polson H; Feldman M; Shokat K; Tooze SA; Urbé S; Clague MJ
    Traffic; 2009 Jul; 10(7):883-93. PubMed ID: 19582903
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
    Sultana F; Morse LR; Picotto G; Liu W; Jha PK; Odgren PR; Battaglino RA
    J Cell Biochem; 2020 Apr; 121(4):2927-2937. PubMed ID: 31692073
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Intermittent inhibition of FYVE finger-containing phosphoinositide kinase induces melanosome degradation in B16F10 melanoma cells.
    Kawaguchi K; Watanabe M; Furukawa S; Koga K; Kanamori H; Ikemoto MJ; Takashima S; Maeda M; Oh-Hashi K; Hirata Y; Furuta K; Takemori H
    Mol Biol Rep; 2023 Jul; 50(7):5917-5930. PubMed ID: 37248430
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.
    Muniyappa H; Das KC
    Cell Signal; 2008 Apr; 20(4):675-83. PubMed ID: 18222647
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.