These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 3700401)

  • 1. The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.
    Allegra CJ; Fine RL; Drake JC; Chabner BA
    J Biol Chem; 1986 May; 261(14):6478-85. PubMed ID: 3700401
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
    Allegra CJ; Hoang K; Yeh GC; Drake JC; Baram J
    J Biol Chem; 1987 Oct; 262(28):13520-6. PubMed ID: 2443493
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells.
    Chu E; Drake JC; Boarman D; Baram J; Allegra CJ
    J Biol Chem; 1990 May; 265(15):8470-8. PubMed ID: 2341391
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intracellular metabolism of 5-methyltetrahydrofolate and 5-formyltetrahydrofolate in a human breast-cancer cell line.
    Voeller DM; Allegra CJ
    Cancer Chemother Pharmacol; 1994; 34(6):491-6. PubMed ID: 7522978
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of methotrexate on intracellular folate pools in purified myeloid precursor cells from normal human bone marrow.
    Baram J; Allegra CJ; Fine RL; Chabner BA
    J Clin Invest; 1987 Mar; 79(3):692-7. PubMed ID: 3818945
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
    Seither RL; Trent DF; Mikulecky DC; Rape TJ; Goldman ID
    J Biol Chem; 1989 Oct; 264(29):17016-23. PubMed ID: 2529254
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cobalamin dependent methionine synthesis and methyl-folate-trap in human vitamin B12 deficiency.
    Sauer H; Wilmanns W
    Br J Haematol; 1977 Jun; 36(2):189-98. PubMed ID: 871432
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells.
    Baram J; Chabner BA; Drake JC; Fitzhugh AL; Sholar PW; Allegra CJ
    J Biol Chem; 1988 May; 263(15):7105-11. PubMed ID: 3366769
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.
    Houghton PJ; Rahman A; Will CL; Dolnick BJ; Houghton JA
    Cancer Res; 1992 Feb; 52(3):558-65. PubMed ID: 1732043
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells.
    Boarman DM; Baram J; Allegra CJ
    Biochem Pharmacol; 1990 Dec; 40(12):2651-60. PubMed ID: 2260989
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells.
    Bunni M; Doig MT; Donato H; Kesavan V; Priest DG
    Cancer Res; 1988 Jun; 48(12):3398-404. PubMed ID: 3370638
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Folate cycle kinetics in human breast cancer cells.
    Morrison PF; Allegra CJ
    J Biol Chem; 1989 Jun; 264(18):10552-66. PubMed ID: 2732237
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.
    Matherly LH; Muench SP
    Biochem Pharmacol; 1990 Jun; 39(12):2005-14. PubMed ID: 2141258
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells.
    Rhee MS; Coward JK; Galivan J
    Mol Pharmacol; 1992 Nov; 42(5):909-16. PubMed ID: 1435754
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates.
    Jansen G; Westerhof GR; Jarmuszewski MJ; Kathmann I; Rijksen G; Schornagel JH
    J Biol Chem; 1990 Oct; 265(30):18272-7. PubMed ID: 2211701
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo.
    Priest DG; Bunni M; Sirotnak FM
    Cancer Res; 1989 Aug; 49(15):4204-9. PubMed ID: 2743307
    [TBL] [Abstract][Full Text] [Related]  

  • 17. High-performance liquid chromatographic determination of the distribution of naturally occurring folic acid derivatives in rat liver.
    Wilson SD; Horne DW
    Anal Biochem; 1984 Nov; 142(2):529-35. PubMed ID: 6442107
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
    Jansen G; Mauritz RM; Assaraf YG; Sprecher H; Drori S; Kathmann I; Westerhof GR; Priest DG; Bunni M; Pinedo HM; Schornagel JH; Peters GJ
    Adv Enzyme Regul; 1997; 37():59-76. PubMed ID: 9381986
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Trace enrichment of biological folates on solid-phase adsorption cartridges and analysis by high-pressure liquid chromatography.
    Rebello T
    Anal Biochem; 1987 Oct; 166(1):55-64. PubMed ID: 3674417
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thymidylate synthase, dihydrofolate reductase, folyl binder, 10-formyl-H4PteGlu synthetase, 5,10-methenyl-H4PteGlu cyclohydrolase and 5,10-methylene-H4PteGlu dehydrogenase derived from cells of human origin.
    Cheng YC; Domin BA; Conrad D
    Adv Exp Med Biol; 1983; 163():85-94. PubMed ID: 6351556
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.