BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 37022445)

  • 1. Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.
    Martínez-Sena T; Moro E; Moreno-Torres M; Quintás G; Hengstler J; Castell JV
    Arch Toxicol; 2023 Jun; 97(6):1723-1738. PubMed ID: 37022445
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury.
    García-Cañaveras JC; Castell JV; Donato MT; Lahoz A
    Sci Rep; 2016 Jun; 6():27239. PubMed ID: 27265840
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Sakatis MZ; Reese MJ; Harrell AW; Taylor MA; Baines IA; Chen L; Bloomer JC; Yang EY; Ellens HM; Ambroso JL; Lovatt CA; Ayrton AD; Clarke SE
    Chem Res Toxicol; 2012 Oct; 25(10):2067-82. PubMed ID: 22931300
    [TBL] [Abstract][Full Text] [Related]  

  • 4. LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells.
    García-Cañaveras JC; Jiménez N; Gómez-Lechón MJ; Castell JV; Donato MT; Lahoz A
    Electrophoresis; 2015 Sep; 36(18):2294-2302. PubMed ID: 26031481
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.
    Gerets HH; Tilmant K; Gerin B; Chanteux H; Depelchin BO; Dhalluin S; Atienzar FA
    Cell Biol Toxicol; 2012 Apr; 28(2):69-87. PubMed ID: 22258563
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The use of hepatocytes to investigate drug toxicity.
    Gómez-Lechón MJ; Castell JV; Donato MT
    Methods Mol Biol; 2010; 640():389-415. PubMed ID: 20645064
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
    Albrecht W; Kappenberg F; Brecklinghaus T; Stoeber R; Marchan R; Zhang M; Ebbert K; Kirschner H; Grinberg M; Leist M; Moritz W; Cadenas C; Ghallab A; Reinders J; Vartak N; van Thriel C; Golka K; Tolosa L; Castell JV; Damm G; Seehofer D; Lampen A; Braeuning A; Buhrke T; Behr AC; Oberemm A; Gu X; Kittana N; van de Water B; Kreiling R; Fayyaz S; van Aerts L; Smedsrød B; Ellinger-Ziegelbauer H; Steger-Hartmann T; Gundert-Remy U; Zeigerer A; Ullrich A; Runge D; Lee SML; Schiergens TS; Kuepfer L; Aguayo-Orozco A; Sachinidis A; Edlund K; Gardner I; Rahnenführer J; Hengstler JG
    Arch Toxicol; 2019 Jun; 93(6):1609-1637. PubMed ID: 31250071
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro.
    Fan Q; Zhao B; Wang C; Zhang J; Wu J; Wang T; Xu A
    Molecules; 2018 Sep; 23(10):. PubMed ID: 30274140
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay.
    Brecklinghaus T; Albrecht W; Duda J; Kappenberg F; Gründler L; Edlund K; Marchan R; Ghallab A; Cadenas C; Rieck A; Vartak N; Tolosa L; Castell JV; Gardner I; Halilbasic E; Trauner M; Ullrich A; Zeigerer A; Demirci Turgunbayer Ö; Damm G; Seehofer D; Rahnenführer J; Hengstler JG
    Toxicol Lett; 2022 Sep; 368():33-46. PubMed ID: 35963427
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.
    Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R
    Toxicol Sci; 2016 Jul; 152(1):214-29. PubMed ID: 27208088
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A high content screening assay to predict human drug-induced liver injury during drug discovery.
    Persson M; Løye AF; Mow T; Hornberg JJ
    J Pharmacol Toxicol Methods; 2013; 68(3):302-13. PubMed ID: 23933113
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The assessment of the potential hepatotoxicity of new drugs by
    Quintás G; Castell JV; Moreno-Torres M
    Front Pharmacol; 2023; 14():1155271. PubMed ID: 37214440
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Integrated spatially resolved metabolomics and network toxicology to investigate the hepatotoxicity mechanisms of component D of Polygonum multiflorum Thunb.
    Jiang HY; Gao HY; Li J; Zhou TY; Wang ST; Yang JB; Hao RR; Pang F; Wei F; Liu ZG; Kuang L; Ma SC; He JM; Jin HT
    J Ethnopharmacol; 2022 Nov; 298():115630. PubMed ID: 35987407
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.
    Tolosa L; Donato MT; Pérez-Cataldo G; Castell JV; Gómez-Lechón MJ
    Toxicol In Vitro; 2012 Dec; 26(8):1272-7. PubMed ID: 22138474
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
    Cosgrove BD; King BM; Hasan MA; Alexopoulos LG; Farazi PA; Hendriks BS; Griffith LG; Sorger PK; Tidor B; Xu JJ; Lauffenburger DA
    Toxicol Appl Pharmacol; 2009 Jun; 237(3):317-30. PubMed ID: 19362101
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
    Moreno-Torres M; García-Llorens G; Moro E; Méndez R; Quintás G; Castell JV
    Sci Rep; 2021 Nov; 11(1):22119. PubMed ID: 34764412
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human-Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans.
    Goda K; Kobayashi A; Takahashi A; Takahashi T; Saito K; Maekawa K; Saito Y; Sugai S
    Int J Mol Sci; 2017 Apr; 18(4):. PubMed ID: 28417920
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analysis of extracellular metabolome by HS-SPME/GC-MS: Optimization and application in a pilot study to evaluate galactosamine-induced hepatotoxicity.
    Araújo AM; Moreira N; Lima AR; Bastos ML; Carvalho F; Carvalho M; Guedes de Pinho P
    Toxicol Lett; 2018 Oct; 295():22-31. PubMed ID: 29852275
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro evaluation of potential hepatotoxicity induced by drugs.
    Gómez-Lechón MJ; Lahoz A; Gombau L; Castell JV; Donato MT
    Curr Pharm Des; 2010 Jun; 16(17):1963-77. PubMed ID: 20236064
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
    Tolosa L; Pinto S; Donato MT; Lahoz A; Castell JV; O'Connor JE; Gómez-Lechón MJ
    Toxicol Sci; 2012 May; 127(1):187-98. PubMed ID: 22331495
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.