219 related articles for article (PubMed ID: 37043534)
1. Differential requirements for P stalk components in activating yeast protein kinase Gcn2 by stalled ribosomes during stress.
Gupta R; Hinnebusch AG
Proc Natl Acad Sci U S A; 2023 Apr; 120(16):e2300521120. PubMed ID: 37043534
[TBL] [Abstract][Full Text] [Related]
2. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.
Marton MJ; Vazquez de Aldana CR; Qiu H; Chakraburtty K; Hinnebusch AG
Mol Cell Biol; 1997 Aug; 17(8):4474-89. PubMed ID: 9234705
[TBL] [Abstract][Full Text] [Related]
3. The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
Harding HP; Ordonez A; Allen F; Parts L; Inglis AJ; Williams RL; Ron D
Elife; 2019 Nov; 8():. PubMed ID: 31749445
[TBL] [Abstract][Full Text] [Related]
4. Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.
Visweswaraiah J; Lee SJ; Hinnebusch AG; Sattlegger E
J Biol Chem; 2012 Nov; 287(45):37757-68. PubMed ID: 22888004
[TBL] [Abstract][Full Text] [Related]
5. Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.
Ramirez M; Wek RC; Vazquez de Aldana CR; Jackson BM; Freeman B; Hinnebusch AG
Mol Cell Biol; 1992 Dec; 12(12):5801-15. PubMed ID: 1448107
[TBL] [Abstract][Full Text] [Related]
6. The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
Wek SA; Zhu S; Wek RC
Mol Cell Biol; 1995 Aug; 15(8):4497-506. PubMed ID: 7623840
[TBL] [Abstract][Full Text] [Related]
7. GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.
Marton MJ; Crouch D; Hinnebusch AG
Mol Cell Biol; 1993 Jun; 13(6):3541-56. PubMed ID: 8497269
[TBL] [Abstract][Full Text] [Related]
8. Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity.
Visweswaraiah J; Lageix S; Castilho BA; Izotova L; Kinzy TG; Hinnebusch AG; Sattlegger E
J Biol Chem; 2011 Oct; 286(42):36568-79. PubMed ID: 21849502
[TBL] [Abstract][Full Text] [Related]
9. Activation of GCN2 by the ribosomal P-stalk.
Inglis AJ; Masson GR; Shao S; Perisic O; McLaughlin SH; Hegde RS; Williams RL
Proc Natl Acad Sci U S A; 2019 Mar; 116(11):4946-4954. PubMed ID: 30804176
[TBL] [Abstract][Full Text] [Related]
10. GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.
Vazquez de Aldana CR; Marton MJ; Hinnebusch AG
EMBO J; 1995 Jul; 14(13):3184-99. PubMed ID: 7621831
[TBL] [Abstract][Full Text] [Related]
11. Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation.
Sattlegger E; Hinnebusch AG
J Biol Chem; 2005 Apr; 280(16):16514-21. PubMed ID: 15722345
[TBL] [Abstract][Full Text] [Related]
12. Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation.
Garcia-Barrio M; Dong J; Ufano S; Hinnebusch AG
EMBO J; 2000 Apr; 19(8):1887-99. PubMed ID: 10775272
[TBL] [Abstract][Full Text] [Related]
13. Structure of Gcn1 bound to stalled and colliding 80S ribosomes.
Pochopien AA; Beckert B; Kasvandik S; Berninghausen O; Beckmann R; Tenson T; Wilson DN
Proc Natl Acad Sci U S A; 2021 Apr; 118(14):. PubMed ID: 33790014
[TBL] [Abstract][Full Text] [Related]
14. Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions.
Misra J; Carlson KR; Spandau DF; Wek RC
Nucleic Acids Res; 2024 Feb; 52(4):1830-1846. PubMed ID: 38281137
[TBL] [Abstract][Full Text] [Related]
15. Regulation of translation initiation by amino acids in eukaryotic cells.
Kimball SR
Prog Mol Subcell Biol; 2001; 26():155-84. PubMed ID: 11575165
[TBL] [Abstract][Full Text] [Related]
16. Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.
Garcia-Barrio M; Dong J; Cherkasova VA; Zhang X; Zhang F; Ufano S; Lai R; Qin J; Hinnebusch AG
J Biol Chem; 2002 Aug; 277(34):30675-83. PubMed ID: 12070158
[TBL] [Abstract][Full Text] [Related]
17. Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.
Lageix S; Zhang J; Rothenburg S; Hinnebusch AG
PLoS Genet; 2015 Feb; 11(2):e1004991. PubMed ID: 25695491
[TBL] [Abstract][Full Text] [Related]
18. YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.
Sattlegger E; Swanson MJ; Ashcraft EA; Jennings JL; Fekete RA; Link AJ; Hinnebusch AG
J Biol Chem; 2004 Jul; 279(29):29952-62. PubMed ID: 15126500
[TBL] [Abstract][Full Text] [Related]
19. Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae.
Zaborske JM; Wu X; Wek RC; Pan T
BMC Biochem; 2010 Aug; 11():29. PubMed ID: 20684782
[TBL] [Abstract][Full Text] [Related]
20. Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.
Kubota H; Obata T; Ota K; Sasaki T; Ito T
J Biol Chem; 2003 Jun; 278(23):20457-60. PubMed ID: 12676950
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]