BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 37062794)

  • 1. Ligand-based 3D pharmacophore modeling, virtual screening, and molecular dynamic simulation of potential smoothened inhibitors.
    Mohebbi A
    J Mol Model; 2023 Apr; 29(5):143. PubMed ID: 37062794
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular Modelling of Berberine Derivatives as Inhibitors of Human Smoothened Receptor and Hedgehog Signalling Pathway Using a Newly Developed Algorithm on Anti-Cancer Drugs.
    Kaboli PJ; Bazrafkan M; Ismail P; Ling KH
    Recent Pat Anticancer Drug Discov; 2017 Nov; 12(4):384-400. PubMed ID: 28969581
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.
    Infante P; Alfonsi R; Ingallina C; Quaglio D; Ghirga F; D'Acquarica I; Bernardi F; Di Magno L; Canettieri G; Screpanti I; Gulino A; Botta B; Mori M; Di Marcotullio L
    Cell Death Dis; 2016 Sep; 7(9):e2376. PubMed ID: 27899820
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Deciphering structural stability and binding mechanisms of potential antagonists with smoothened protein.
    Sinha N; Chowdhury S; Sarkar RR
    J Biomol Struct Dyn; 2018 Aug; 36(11):2917-2937. PubMed ID: 28849750
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.
    Peluso MO; Campbell VT; Harari JA; Tibbitts TT; Proctor JL; Whitebread N; Conley JM; White KF; Kutok JL; Read MA; McGovern K; Faia KL
    PLoS One; 2014; 9(3):e90534. PubMed ID: 24608250
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.
    Lu W; Zhang D; Ma H; Tian S; Zheng J; Wang Q; Luo L; Zhang X
    Eur J Med Chem; 2018 Jul; 155():34-48. PubMed ID: 29857275
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Developing new PI3Kγ inhibitors by combining pharmacophore modeling, molecular dynamic simulation, molecular docking, fragment-based drug design, and virtual screening.
    Zhu J; Sun D; Li X; Jia L; Cai Y; Chen Y; Jin J; Yu L
    Comput Biol Chem; 2023 Jun; 104():107879. PubMed ID: 37182359
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Overcoming the emerging drug resistance of smoothened: an overview of small-molecule SMO antagonists with antiresistance activity.
    Zhang H; Sun Z; Liu Z; Song C
    Future Med Chem; 2018 Dec; 10(24):2855-2875. PubMed ID: 30557039
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacophore based virtual screening for identification of effective inhibitors to combat HPV 16 E6 driven cervical cancer.
    Mohan A; Krishnamoorthy S; Sabanayagam R; Schwenk G; Feng E; Ji HF; Muthusami S
    Eur J Pharmacol; 2023 Oct; 957():175961. PubMed ID: 37549730
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural optimization on a virtual screening hit of smoothened receptor.
    Song S; Jiang J; Zhao L; Wang Q; Lu W; Zheng C; Zhang J; Ma H; Tian S; Zheng J; Luo L; Li Y; Yang ZJ; Zhang X
    Eur J Med Chem; 2019 Jun; 172():1-15. PubMed ID: 30939349
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular basis of drug resistance in smoothened receptor: An in silico study of protein resistivity and specificity.
    Sinha N; Chowdhury S; Sarkar RR
    Proteins; 2020 Mar; 88(3):514-526. PubMed ID: 31589795
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles.
    Liu M; Liang G; Zheng H; Zheng N; Ge H; Liu W
    Life Sci; 2019 Jan; 217():222-228. PubMed ID: 30543826
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol, rather as a BH3 mimetic.
    Wang J; Zhang Y; Huang WJ; Yang J; Tang WG; Huang TM; Tan WF
    Acta Pharmacol Sin; 2021 Jun; 42(6):1005-1013. PubMed ID: 32855528
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine.
    Kozielewicz P; Bowin CF; Turku A; Schulte G
    Mol Pharmacol; 2020 Jan; 97(1):23-34. PubMed ID: 31707356
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.
    Wang Y; Arvanites AC; Davidow L; Blanchard J; Lam K; Yoo JW; Coy S; Rubin LL; McMahon AP
    ACS Chem Biol; 2012 Jun; 7(6):1040-8. PubMed ID: 22554036
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.
    Tian N; Wu H; Zhang H; Yang D; Lv L; Yang Z; Zhang T; Quan D; Zhou L; Xie Y; Xu Y; Wei N; Zhang J; Chen M; Schmitz JC; Tian Y; Wu S
    Bioorg Med Chem; 2020 Aug; 28(16):115584. PubMed ID: 32690258
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural dynamics of Smoothened (SMO) in the ciliary membrane and its interaction with membrane lipids.
    Kumari S; Mitra A; Bulusu G
    Biochim Biophys Acta Biomembr; 2022 Aug; 1864(8):183946. PubMed ID: 35483421
    [TBL] [Abstract][Full Text] [Related]  

  • 18. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
    Gruber W; Hutzinger M; Elmer DP; Parigger T; Sternberg C; Cegielkowski L; Zaja M; Leban J; Michel S; Hamm S; Vitt D; Aberger F
    Oncotarget; 2016 Feb; 7(6):7134-48. PubMed ID: 26784250
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
    Li QR; Zhao H; Zhang XS; Lang H; Yu K
    Acta Pharmacol Sin; 2019 Feb; 40(2):257-267. PubMed ID: 29777201
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacoinformatics exploration of polyphenol oxidases leading to novel inhibitors by virtual screening and molecular dynamic simulation study.
    Hassan M; Abbas Q; Ashraf Z; Moustafa AA; Seo SY
    Comput Biol Chem; 2017 Jun; 68():131-142. PubMed ID: 28340400
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.