BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

169 related articles for article (PubMed ID: 37086089)

  • 1. Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12-RILPL1-dependent manner.
    Ito K; Araki M; Katai Y; Nishimura Y; Imotani S; Inoue H; Ito G; Tomita T
    FASEB J; 2023 May; 37(5):e22930. PubMed ID: 37086089
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
    Wang X; Bondar VV; Davis OB; Maloney MT; Agam M; Chin MY; Cheuk-Nga Ho A; Ghosh R; Leto DE; Joy D; Calvert MEK; Lewcock JW; Di Paolo G; Thorne RG; Sweeney ZK; Henry AG
    Elife; 2023 Oct; 12():. PubMed ID: 37874617
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Lysosomal positioning regulates Rab10 phosphorylation at LRRK2
    Kluss JH; Beilina A; Williamson CD; Lewis PA; Cookson MR; Bonet-Ponce L
    Proc Natl Acad Sci U S A; 2022 Oct; 119(43):e2205492119. PubMed ID: 36256825
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
    Dhekne HS; Tonelli F; Yeshaw WM; Chiang CY; Limouse C; Jaimon E; Purlyte E; Alessi DR; Pfeffer SR
    Elife; 2023 Oct; 12():. PubMed ID: 37874635
    [TBL] [Abstract][Full Text] [Related]  

  • 5. LRRK2-mediated phosphorylation and thermal stability of Rab12 are regulated by bound nucleotides.
    Ito G; Tomita T; Utsunomiya-Tate N
    Biochem Biophys Res Commun; 2023 Jul; 667():43-49. PubMed ID: 37207563
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
    Kluss JH; Bonet-Ponce L; Lewis PA; Cookson MR
    Neurobiol Dis; 2022 Aug; 170():105769. PubMed ID: 35580815
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
    Steger M; Diez F; Dhekne HS; Lis P; Nirujogi RS; Karayel O; Tonelli F; Martinez TN; Lorentzen E; Pfeffer SR; Alessi DR; Mann M
    Elife; 2017 Nov; 6():. PubMed ID: 29125462
    [TBL] [Abstract][Full Text] [Related]  

  • 8. RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
    Lara Ordónez AJ; Fernández B; Fdez E; Romo-Lozano M; Madero-Pérez J; Lobbestael E; Baekelandt V; Aiastui A; López de Munaín A; Melrose HL; Civiero L; Hilfiker S
    Hum Mol Genet; 2019 Nov; 28(21):3552-3568. PubMed ID: 31428781
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
    Kalogeropulou AF; Freemantle JB; Lis P; Vides EG; Polinski NK; Alessi DR
    Biochem J; 2020 Nov; 477(22):4397-4423. PubMed ID: 33135724
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
    Sobu Y; Wawro PS; Dhekne HS; Yeshaw WM; Pfeffer SR
    Proc Natl Acad Sci U S A; 2021 Mar; 118(10):. PubMed ID: 33653948
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
    Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
    Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain.
    Kelly K; Chang A; Hastings L; Abdelmotilib H; West AB
    Brain Res; 2021 May; 1759():147372. PubMed ID: 33600829
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of phospho-specific Rab protein antibodies to monitor
    Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
    Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.
    Lara Ordóñez AJ; Fasiczka R; Fernández B; Naaldijk Y; Fdez E; Blanca Ramírez M; Phan S; Boassa D; Hilfiker S
    Biol Open; 2022 Aug; 11(8):. PubMed ID: 35776681
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.
    Kuwahara T; Funakawa K; Komori T; Sakurai M; Yoshii G; Eguchi T; Fukuda M; Iwatsubo T
    Neurobiol Dis; 2020 Nov; 145():105081. PubMed ID: 32919031
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.
    Thirstrup K; Dächsel JC; Oppermann FS; Williamson DS; Smith GP; Fog K; Christensen KV
    Sci Rep; 2017 Aug; 7(1):10300. PubMed ID: 28860483
    [TBL] [Abstract][Full Text] [Related]  

  • 17. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
    Eguchi T; Kuwahara T; Sakurai M; Komori T; Fujimoto T; Ito G; Yoshimura SI; Harada A; Fukuda M; Koike M; Iwatsubo T
    Proc Natl Acad Sci U S A; 2018 Sep; 115(39):E9115-E9124. PubMed ID: 30209220
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2.
    Bonet-Ponce L; Tegicho T; Beilina A; Kluss JH; Li Y; Cookson MR
    bioRxiv; 2024 Apr; ():. PubMed ID: 38903076
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Role of LRRK2 in Intracellular Organelle Dynamics.
    Boecker CA
    J Mol Biol; 2023 Jun; 435(12):167998. PubMed ID: 36764357
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
    Malik AU; Karapetsas A; Nirujogi RS; Mathea S; Chatterjee D; Pal P; Lis P; Taylor M; Purlyte E; Gourlay R; Dorward M; Weidlich S; Toth R; Polinski NK; Knapp S; Tonelli F; Alessi DR
    Biochem J; 2021 Feb; 478(3):553-578. PubMed ID: 33459343
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.