These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
131 related articles for article (PubMed ID: 37126536)
1. Setmelanotide optimization through fragment-growing, molecular docking in-silico method targeting MC4 receptor. Jia X; Fan S; Dong W; Li S; Zhang Y; Ma Y; Wang S J Biomol Struct Dyn; 2023; 41(24):15411-15420. PubMed ID: 37126536 [TBL] [Abstract][Full Text] [Related]
2. Structural analysis of setmelanotide binding to MC4R variants in comparison to wild-type receptor. Hammad MM; Mohammad A; Alam-Eldin N; Madhu D; Al-Mulla F; Abu-Farha M; Abubaker J Life Sci; 2022 Oct; 307():120857. PubMed ID: 35931197 [TBL] [Abstract][Full Text] [Related]
3. Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach. Falls BA; Zhang Y ACS Chem Neurosci; 2019 Mar; 10(3):1055-1065. PubMed ID: 30048591 [TBL] [Abstract][Full Text] [Related]
8. Setmelanotide: First Approval. Markham A Drugs; 2021 Feb; 81(3):397-403. PubMed ID: 33638809 [TBL] [Abstract][Full Text] [Related]
9. Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants. Haskell-Luevano C; Cone RD; Monck EK; Wan YP Biochemistry; 2001 May; 40(20):6164-79. PubMed ID: 11352754 [TBL] [Abstract][Full Text] [Related]
10. Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R). Singh A; Dirain ML; Wilczynski A; Chen C; Gosnell BA; Levine AS; Edison AS; Haskell-Luevano C ACS Chem Neurosci; 2014 Oct; 5(10):1020-31. PubMed ID: 25141170 [TBL] [Abstract][Full Text] [Related]
11. Substituted NDP-MSH peptides paired with mutant melanocortin-4 receptors demonstrate the role of transmembrane 6 in receptor activation. Fleck BA; Ling N; Chen C Biochemistry; 2007 Sep; 46(37):10473-83. PubMed ID: 17713970 [TBL] [Abstract][Full Text] [Related]
12. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. Hruby VJ; Lu D; Sharma SD; Castrucci AL; Kesterson RA; al-Obeidi FA; Hadley ME; Cone RD J Med Chem; 1995 Sep; 38(18):3454-61. PubMed ID: 7658432 [TBL] [Abstract][Full Text] [Related]
13. Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide. Heyder NA; Kleinau G; Speck D; Schmidt A; Paisdzior S; Szczepek M; Bauer B; Koch A; Gallandi M; Kwiatkowski D; Bürger J; Mielke T; Beck-Sickinger AG; Hildebrand PW; Spahn CMT; Hilger D; Schacherl M; Biebermann H; Hilal T; Kühnen P; Kobilka BK; Scheerer P Cell Res; 2021 Nov; 31(11):1176-1189. PubMed ID: 34561620 [TBL] [Abstract][Full Text] [Related]
14. Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor. Fleck BA; Chen C; Yang W; Huntley R; Markison S; Nickolls SA; Foster AC; Hoare SR Biochemistry; 2005 Nov; 44(44):14494-508. PubMed ID: 16262250 [TBL] [Abstract][Full Text] [Related]
15. Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. Carotenuto A; Merlino F; Cai M; Brancaccio D; Yousif AM; Novellino E; Hruby VJ; Grieco P J Med Chem; 2015 Dec; 58(24):9773-8. PubMed ID: 26599352 [TBL] [Abstract][Full Text] [Related]
16. Multimeric alpha-MSH has increased efficacy to activate the melanocortin MC4 receptor. Tiesjema B; Merkestein M; Garner KM; de Krom M; Adan RA Eur J Pharmacol; 2008 May; 585(1):24-30. PubMed ID: 18378226 [TBL] [Abstract][Full Text] [Related]