BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

243 related articles for article (PubMed ID: 37127652)

  • 1. Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition.
    Vo T; Balderson B; Jones K; Ni G; Crawford J; Millar A; Tolson E; Singleton M; Kojic M; Robertson T; Walters S; Mulay O; Bhuva DD; Davis MJ; Wainwright BJ; Nguyen Q; Genovesi LA
    Genome Med; 2023 May; 15(1):29. PubMed ID: 37127652
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hedgehog pathway permissive conditions allow generation of immortal cell lines from granule cells derived from cancerous and non-cancerous cerebellum.
    Heil C
    Open Biol; 2019 Jan; 9(1):180145. PubMed ID: 30958113
    [TBL] [Abstract][Full Text] [Related]  

  • 3. p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.
    Bhatia B; Malik A; Fernandez-L A; Kenney AM
    Cell Cycle; 2010 Nov; 9(21):4307-14. PubMed ID: 21051932
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression.
    Milla LA; Arros A; Espinoza N; Remke M; Kool M; Taylor MD; Pfister SM; Wainwright BJ; Palma V
    Int J Cancer; 2014 Jan; 134(1):21-31. PubMed ID: 23775842
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.
    Daggubati V; Hochstelter J; Bommireddy A; Choudhury A; Krup AL; Kaur P; Tong P; Li A; Xu L; Reiter JF; Raleigh DR
    J Clin Invest; 2021 Mar; 131(6):. PubMed ID: 33476305
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation.
    Tan IL; Wojcinski A; Rallapalli H; Lao Z; Sanghrajka RM; Stephen D; Volkova E; Korshunov A; Remke M; Taylor MD; Turnbull DH; Joyner AL
    Proc Natl Acad Sci U S A; 2018 Mar; 115(13):3392-3397. PubMed ID: 29531057
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma.
    Luo W; Lin GN; Song W; Zhang Y; Lai H; Zhang M; Miao J; Cheng X; Wang Y; Li W; Wei W; Gao WQ; Yang R; Wang J
    BMC Biol; 2021 Jul; 19(1):135. PubMed ID: 34210306
    [TBL] [Abstract][Full Text] [Related]  

  • 8. PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.
    Singh AR; Joshi S; Zulcic M; Alcaraz M; Garlich JR; Morales GA; Cho YJ; Bao L; Levy ML; Newbury R; Malicki D; Messer K; Crawford J; Durden DL
    PLoS One; 2016; 11(3):e0150836. PubMed ID: 26938241
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models.
    Cook Sangar ML; Genovesi LA; Nakamoto MW; Davis MJ; Knobluagh SE; Ji P; Millar A; Wainwright BJ; Olson JM
    Clin Cancer Res; 2017 Oct; 23(19):5802-5813. PubMed ID: 28637687
    [No Abstract]   [Full Text] [Related]  

  • 10. Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.
    Al-Halabi H; Nantel A; Klekner A; Guiot MC; Albrecht S; Hauser P; Garami M; Bognar L; Kavan P; Gerges N; Shirinian M; Roberge D; Muanza T; Jabado N
    Acta Neuropathol; 2011 Feb; 121(2):229-39. PubMed ID: 21107850
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.
    Northcott PA; Fernandez-L A; Hagan JP; Ellison DW; Grajkowska W; Gillespie Y; Grundy R; Van Meter T; Rutka JT; Croce CM; Kenney AM; Taylor MD
    Cancer Res; 2009 Apr; 69(8):3249-55. PubMed ID: 19351822
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.
    Purzner T; Purzner J; Buckstaff T; Cozza G; Gholamin S; Rusert JM; Hartl TA; Sanders J; Conley N; Ge X; Langan M; Ramaswamy V; Ellis L; Litzenburger U; Bolin S; Theruvath J; Nitta R; Qi L; Li XN; Li G; Taylor MD; Wechsler-Reya RJ; Pinna LA; Cho YJ; Fuller MT; Elias JE; Scott MP
    Sci Signal; 2018 Sep; 11(547):. PubMed ID: 30206138
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks.
    Po A; Abballe L; Sabato C; Gianno F; Chiacchiarini M; Catanzaro G; De Smaele E; Giangaspero F; Ferretti E; Miele E; Besharat ZM
    Int J Mol Sci; 2018 Aug; 19(8):. PubMed ID: 30096798
    [TBL] [Abstract][Full Text] [Related]  

  • 14. IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma.
    Kunhiraman H; McSwain L; Shahab SW; Gershon TR; MacDonald TJ; Kenney AM
    Acta Neuropathol Commun; 2023 Apr; 11(1):62. PubMed ID: 37029430
    [TBL] [Abstract][Full Text] [Related]  

  • 15. YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.
    Dey A; Robitaille M; Remke M; Maier C; Malhotra A; Gregorieff A; Wrana JL; Taylor MD; Angers S; Kenney AM
    Oncogene; 2016 Aug; 35(32):4256-68. PubMed ID: 26725322
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.
    Riemondy KA; Venkataraman S; Willard N; Nellan A; Sanford B; Griesinger AM; Amani V; Mitra S; Hankinson TC; Handler MH; Sill M; Ocasio J; Weir SJ; Malawsky DS; Gershon TR; Garancher A; Wechsler-Reya RJ; Hesselberth JR; Foreman NK; Donson AM; Vibhakar R
    Neuro Oncol; 2022 Feb; 24(2):273-286. PubMed ID: 34077540
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging.
    Linke F; Johnson JEC; Kern S; Bennett CD; Lourdusamy A; Lea D; Clifford SC; Merry CLR; Stolnik S; Alexander MR; Peet AC; Scurr DJ; Griffiths RL; Grabowska AM; Kerr ID; Coyle B
    Acta Neuropathol Commun; 2023 Jan; 11(1):6. PubMed ID: 36631900
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Transcriptional repressor REST drives lineage stage-specific chromatin compaction at
    Dobson THW; Tao RH; Swaminathan J; Maegawa S; Shaik S; Bravo-Alegria J; Sharma A; Kennis B; Yang Y; Callegari K; Haltom AR; Taylor P; Kogiso M; Qi L; Khatua S; Goldman S; Lulla RR; Fangusaro J; MacDonald TJ; Li XN; Hawkins C; Rajaram V; Gopalakrishnan V
    Sci Signal; 2019 Jan; 12(565):. PubMed ID: 30670636
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Exosomal microRNAs induce tumor-associated macrophages via PPARγ during tumor progression in SHH medulloblastoma.
    Zhu L; Yang Y; Li H; Xu L; You H; Liu Y; Liu Z; Liu X; Zheng D; Bie J; Li J; Song C; Yang B; Luo J; Chang Q
    Cancer Lett; 2022 Jun; 535():215630. PubMed ID: 35304257
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma.
    Pak E; MacKenzie EL; Zhao X; Pazyra-Murphy MF; Park PMC; Wu L; Shaw DL; Addleson EC; Cayer SS; Lopez BG; Agar NYR; Rubin LL; Qi J; Merk DJ; Segal RA
    Neuro Oncol; 2019 Sep; 21(9):1150-1163. PubMed ID: 31111916
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.