BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 37216523)

  • 1. Molecular mechanism of fatty acid activation of FFAR1.
    Kumari P; Inoue A; Chapman K; Lian P; Rosenbaum DM
    Proc Natl Acad Sci U S A; 2023 May; 120(22):e2219569120. PubMed ID: 37216523
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1.
    Yabuki C; Komatsu H; Tsujihata Y; Maeda R; Ito R; Matsuda-Nagasumi K; Sakuma K; Miyawaki K; Kikuchi N; Takeuchi K; Habata Y; Mori M
    PLoS One; 2013; 8(10):e76280. PubMed ID: 24130766
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics.
    Atanasio S; Deganutti G; Reynolds CA
    J Comput Aided Mol Des; 2020 Nov; 34(11):1181-1193. PubMed ID: 32851580
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2.
    Petersen JE; Pedersen MH; Dmytriyeva O; Nellemose E; Arora T; Engelstoft MS; Asher WB; Javitch JA; Schwartz TW; Trauelsen M
    Mol Metab; 2023 Aug; 74():101757. PubMed ID: 37348738
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans.
    Wagner R; Kaiser G; Gerst F; Christiansen E; Due-Hansen ME; Grundmann M; Machicao F; Peter A; Kostenis E; Ulven T; Fritsche A; Häring HU; Ullrich S
    Diabetes; 2013 Jun; 62(6):2106-11. PubMed ID: 23378609
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure.
    Kristinsson H; Bergsten P; Sargsyan E
    Biochim Biophys Acta; 2015 Dec; 1853(12):3248-57. PubMed ID: 26408932
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1.
    Nishino K; Uesugi H; Hirasawa A; Ohtera A; Miyamae Y; Neffati M; Isoda H; Kambe T; Masuda S; Irie K; Nagao M
    Biochem Biophys Res Commun; 2020 Jan; 522(1):68-73. PubMed ID: 31740001
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus.
    Rani L; Grewal AS; Sharma N; Singh S
    Mini Rev Med Chem; 2021; 21(4):426-470. PubMed ID: 33100202
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.
    Lin DC; Guo Q; Luo J; Zhang J; Nguyen K; Chen M; Tran T; Dransfield PJ; Brown SP; Houze J; Vimolratana M; Jiao XY; Wang Y; Birdsall NJ; Swaminath G
    Mol Pharmacol; 2012 Nov; 82(5):843-59. PubMed ID: 22859723
    [TBL] [Abstract][Full Text] [Related]  

  • 10. β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
    Mancini AD; Bertrand G; Vivot K; Carpentier É; Tremblay C; Ghislain J; Bouvier M; Poitout V
    J Biol Chem; 2015 Aug; 290(34):21131-21140. PubMed ID: 26157145
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1.
    Tunaru S; Bonnavion R; Brandenburger I; Preussner J; Thomas D; Scholich K; Offermanns S
    Nat Commun; 2018 Jan; 9(1):177. PubMed ID: 29330456
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation.
    Helal MA; Darwish KM; Hammad MA
    Bioorg Med Chem Lett; 2014 Nov; 24(22):5330-6. PubMed ID: 25441945
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A FFAR1 full agonist restores islet function in models of impaired glucose-stimulated insulin secretion and diabetic non-human primates.
    Rady B; Liu J; Huang H; Bakaj I; Qi J; Lee SP; Martin T; Norquay L; Player M; Pocai A
    Front Endocrinol (Lausanne); 2022; 13():1061688. PubMed ID: 36482991
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution.
    Yoshioka K; Yamashita H; Shimizu K; Shimomura S; Shibata T; Miyazaki JI; Honda H
    Biochem Biophys Res Commun; 2021 Apr; 550():177-183. PubMed ID: 33706101
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets.
    Lorza-Gil E; Kaiser G; Carlein C; Hoffmann MDA; König GM; Haug S; Prates Roma L; Rexen Ulven E; Ulven T; Kostenis E; Birkenfeld AL; Häring HU; Ullrich S; Gerst F
    Diabetologia; 2023 Aug; 66(8):1501-1515. PubMed ID: 37217659
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.
    Sabrautzki S; Kaiser G; Przemeck GKH; Gerst F; Lorza-Gil E; Panse M; Sartorius T; Hoene M; Marschall S; Häring HU; Hrabě de Angelis M; Ullrich S
    Mol Metab; 2017 Oct; 6(10):1304-1312. PubMed ID: 29031729
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle.
    Mizuta K; Zhang Y; Mizuta F; Hoshijima H; Shiga T; Masaki E; Emala CW
    Am J Physiol Lung Cell Mol Physiol; 2015 Nov; 309(9):L970-82. PubMed ID: 26342087
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Physiology and therapeutics of the free fatty acid receptor GPR40.
    Huang H; Dai MH; Tao YX
    Prog Mol Biol Transl Sci; 2014; 121():67-94. PubMed ID: 24373235
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice.
    Chen Y; Ren Q; Zhou Z; Deng L; Hu L; Zhang L; Li Z
    Br J Pharmacol; 2020 May; 177(10):2286-2302. PubMed ID: 31971610
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis for the ligand recognition and signaling of free fatty acid receptors.
    Zhang X; Guseinov AA; Jenkins L; Li K; Tikhonova IG; Milligan G; Zhang C
    Sci Adv; 2024 Jan; 10(2):eadj2384. PubMed ID: 38198545
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.