495 related articles for article (PubMed ID: 37259128)
1. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Schilling S; Pradhan A; Heesch A; Helbig A; Blennow K; Koch C; Bertgen L; Koo EH; Brinkmalm G; Zetterberg H; Kins S; Eggert S
Acta Neuropathol Commun; 2023 Jun; 11(1):87. PubMed ID: 37259128
[TBL] [Abstract][Full Text] [Related]
2. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
Kim M; Bezprozvanny I
Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768421
[TBL] [Abstract][Full Text] [Related]
3. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
[TBL] [Abstract][Full Text] [Related]
4. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
Kimura A; Hata S; Suzuki T
J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
[TBL] [Abstract][Full Text] [Related]
5. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
Kim M; Bezprozvanny I
Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
[TBL] [Abstract][Full Text] [Related]
6. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.
Devkota S; Williams TD; Wolfe MS
J Biol Chem; 2021; 296():100281. PubMed ID: 33450230
[TBL] [Abstract][Full Text] [Related]
7. Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.
Serneels L; T'Syen D; Perez-Benito L; Theys T; Holt MG; De Strooper B
Mol Neurodegener; 2020 Oct; 15(1):60. PubMed ID: 33076948
[TBL] [Abstract][Full Text] [Related]
8. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
[TBL] [Abstract][Full Text] [Related]
9. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase.
Dehury B; Somavarapu AK; Kepp KP
J Struct Biol; 2020 Dec; 212(3):107648. PubMed ID: 33099014
[TBL] [Abstract][Full Text] [Related]
10. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
[TBL] [Abstract][Full Text] [Related]
11. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
Zhang C; Browne A; Kim DY; Tanzi RE
Curr Alzheimer Res; 2010 Feb; 7(1):21-6. PubMed ID: 20205669
[TBL] [Abstract][Full Text] [Related]
12. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.
Arber C; Toombs J; Lovejoy C; Ryan NS; Paterson RW; Willumsen N; Gkanatsiou E; Portelius E; Blennow K; Heslegrave A; Schott JM; Hardy J; Lashley T; Fox NC; Zetterberg H; Wray S
Mol Psychiatry; 2020 Nov; 25(11):2919-2931. PubMed ID: 30980041
[TBL] [Abstract][Full Text] [Related]
13. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL
Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168
[TBL] [Abstract][Full Text] [Related]
14. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
15. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
[TBL] [Abstract][Full Text] [Related]
16. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
17. Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.
Jayne T; Newman M; Verdile G; Sutherland G; Münch G; Musgrave I; Moussavi Nik SH; Lardelli M
J Alzheimers Dis; 2016 Apr; 52(3):781-99. PubMed ID: 27060961
[TBL] [Abstract][Full Text] [Related]
18. A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.
Kwart D; Gregg A; Scheckel C; Murphy EA; Paquet D; Duffield M; Fak J; Olsen O; Darnell RB; Tessier-Lavigne M
Neuron; 2019 Oct; 104(2):256-270.e5. PubMed ID: 31416668
[TBL] [Abstract][Full Text] [Related]
19. Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein.
Do HN; Devkota S; Bhattarai A; Wolfe MS; Miao Y
Commun Biol; 2023 Feb; 6(1):174. PubMed ID: 36788318
[TBL] [Abstract][Full Text] [Related]
20. Aβ43 levels determine the onset of pathological amyloid deposition.
Tambini MD; Yin T; Yesiltepe M; Breuillaud L; Zehntner SP; d'Abramo C; Giliberto L; D'Adamio L
J Biol Chem; 2023 Jul; 299(7):104868. PubMed ID: 37257821
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]