These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 37298854)

  • 21. Water molecule-mediated selective inhibition of bacterial zinc metalloproteinases by non-hydroxamate compounds: Ab initio molecular simulations.
    Saito R; Imai K; Takimoto D; Ezawa T; Sugiyama S; Takimoto-Kamimura M; Kurita N
    J Mol Graph Model; 2022 Jul; 114():108200. PubMed ID: 35453045
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design.
    Kalinin DV; Holl R
    Curr Top Med Chem; 2016; 16(21):2379-430. PubMed ID: 27072691
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009-2012).
    Supuran CT; Carta F; Scozzafava A
    Expert Opin Ther Pat; 2013 Jul; 23(7):777-88. PubMed ID: 23458841
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Antibacterial activities and characterization of novel inhibitors of LpxC.
    Clements JM; Coignard F; Johnson I; Chandler S; Palan S; Waller A; Wijkmans J; Hunter MG
    Antimicrob Agents Chemother; 2002 Jun; 46(6):1793-9. PubMed ID: 12019092
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Lipid a biosynthesis of multidrug-resistant pathogens - a novel drug target.
    Lee CR; Lee JH; Jeong BC; Lee SH
    Curr Pharm Des; 2013; 19(36):6534-50. PubMed ID: 23829374
    [TBL] [Abstract][Full Text] [Related]  

  • 26. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.
    McClerren AL; Endsley S; Bowman JL; Andersen NH; Guan Z; Rudolph J; Raetz CR
    Biochemistry; 2005 Dec; 44(50):16574-83. PubMed ID: 16342948
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.
    Mdluli KE; Witte PR; Kline T; Barb AW; Erwin AL; Mansfield BE; McClerren AL; Pirrung MC; Tumey LN; Warrener P; Raetz CR; Stover CK
    Antimicrob Agents Chemother; 2006 Jun; 50(6):2178-84. PubMed ID: 16723580
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay.
    Langsdorf EF; Malikzay A; Lamarr WA; Daubaras D; Kravec C; Zhang R; Hart R; Monsma F; Black T; Ozbal CC; Miesel L; Lunn CA
    J Biomol Screen; 2010 Jan; 15(1):52-61. PubMed ID: 20019290
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.
    Szermerski M; Melesina J; Wichapong K; Löppenberg M; Jose J; Sippl W; Holl R
    Bioorg Med Chem; 2014 Feb; 22(3):1016-28. PubMed ID: 24412340
    [TBL] [Abstract][Full Text] [Related]  

  • 30. A method to assay inhibitors of lipopolysaccharide synthesis.
    Hernick M; Fierke CA
    Methods Mol Med; 2008; 142():143-54. PubMed ID: 18437312
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies.
    Kalinin DV; Agoglitta O; Van de Vyver H; Melesina J; Wagner S; Riemann B; Schäfers M; Sippl W; Löffler B; Holl R
    Bioorg Med Chem; 2019 May; 27(10):1997-2018. PubMed ID: 30954331
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents.
    Ding S; Dai RY; Wang WK; Cao Q; Lan LF; Zhou XL; Yang YS
    Bioorg Med Chem Lett; 2018 Jan; 28(2):94-102. PubMed ID: 29233653
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
    Jackman JE; Raetz CR; Fierke CA
    Biochemistry; 2001 Jan; 40(2):514-23. PubMed ID: 11148046
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Inhibitors of Selected Bacterial Metalloenzymes.
    Žalubovskis R; Winum JY
    Curr Med Chem; 2019; 26(15):2690-2714. PubMed ID: 29611472
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.
    Lemaître N; Liang X; Najeeb J; Lee CJ; Titecat M; Leteurtre E; Simonet M; Toone EJ; Zhou P; Sebbane F
    mBio; 2017 Jul; 8(4):. PubMed ID: 28743813
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Exploring the UDP pocket of LpxC through amino acid analogs.
    Hale MR; Hill P; Lahiri S; Miller MD; Ross P; Alm R; Gao N; Kutschke A; Johnstone M; Prince B; Thresher J; Yang W
    Bioorg Med Chem Lett; 2013 Apr; 23(8):2362-7. PubMed ID: 23499237
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
    Barb AW; Zhou P
    Curr Pharm Biotechnol; 2008 Feb; 9(1):9-15. PubMed ID: 18289052
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Antibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC.
    Erwin AL
    Cold Spring Harb Perspect Med; 2016 Jul; 6(7):. PubMed ID: 27235477
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors.
    Basak S; Li Y; Tao S; Daryaee F; Merino J; Gu C; Delker SL; Phan JN; Edwards TE; Walker SG; Tonge PJ
    J Med Chem; 2022 Sep; 65(17):11854-11875. PubMed ID: 36037447
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Zinc hydrolases: the mechanisms of zinc-dependent deacetylases.
    Hernick M; Fierke CA
    Arch Biochem Biophys; 2005 Jan; 433(1):71-84. PubMed ID: 15581567
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.