251 related articles for article (PubMed ID: 37312133)
1. Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.
Drobny A; Boros FA; Balta D; Prieto Huarcaya S; Caylioglu D; Qazi N; Vandrey J; Schneider Y; Dobert JP; Pitcairn C; Mazzulli JR; Zunke F
Transl Neurodegener; 2023 Jun; 12(1):31. PubMed ID: 37312133
[TBL] [Abstract][Full Text] [Related]
2. Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Prieto Huarcaya S; Drobny A; Marques ARA; Di Spiezio A; Dobert JP; Balta D; Werner C; Rizo T; Gallwitz L; Bub S; Stojkovska I; Belur NR; Fogh J; Mazzulli JR; Xiang W; Fulzele A; Dejung M; Sauer M; Winner B; Rose-John S; Arnold P; Saftig P; Zunke F
Autophagy; 2022 May; 18(5):1127-1151. PubMed ID: 35287553
[TBL] [Abstract][Full Text] [Related]
3. The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jones-Tabah J; He K; Senkevich K; Karpilovsky N; Deyab G; Cousineau Y; Nikanorova D; Goldsmith T; Del-Cid Pellitero E; Chen CX; Luo W; You Z; Abdian N; Pietrantonio I; Goiran T; Ahmad J; Ruskey JA; Asayesh F; Spiegelman D; Waters C; Monchi O; Dauvilliers Y; Dupre N; Miliukhina I; Timofeeva A; Emelyanov A; Pchelina S; Greenbaum L; HassinBaer S; Alcalay RN; Milnerwood A; Durcan TM; Gan-Or Z; Fon EA
Res Sq; 2024 Mar; ():. PubMed ID: 38562709
[TBL] [Abstract][Full Text] [Related]
4. 14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.
Wang B; Underwood R; Kamath A; Britain C; McFerrin MB; McLean PJ; Volpicelli-Daley LA; Whitaker RH; Placzek WJ; Becker K; Ma J; Yacoubian TA
J Neurosci; 2018 Sep; 38(38):8211-8232. PubMed ID: 30093536
[TBL] [Abstract][Full Text] [Related]
5. Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.
Gentzel RC; Toolan D; Jinn S; Schachter JB; Ma L; Kahle PJ; Smith SM; Marcus JN
Neurobiol Aging; 2021 Oct; 106():12-25. PubMed ID: 34225000
[TBL] [Abstract][Full Text] [Related]
6. Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition.
Pitcairn C; Murata N; Zalon AJ; Stojkovska I; Mazzulli JR
J Neurosci; 2023 Apr; 43(14):2615-2629. PubMed ID: 36788031
[TBL] [Abstract][Full Text] [Related]
7. Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.
Kakuda K; Ikenaka K; Kuma A; Doi J; Aguirre C; Wang N; Ajiki T; Choong CJ; Kimura Y; Badawy SMM; Shima T; Nakamura S; Baba K; Nagano S; Nagai Y; Yoshimori T; Mochizuki H
Proc Natl Acad Sci U S A; 2024 Jan; 121(1):e2312306120. PubMed ID: 38147546
[TBL] [Abstract][Full Text] [Related]
8. The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jones-Tabah J; He K; Senkevich K; Karpilovsky N; Deyab G; Cousineau Y; Nikanorova D; Goldsmith T; Del Cid Pellitero E; Chen CX; Luo W; You Z; Abdian N; Pietrantonio I; Goiran T; Ahmad J; Ruskey JA; Asayesh F; Spiegelman D; Waters C; Monchi O; Dauvilliers Y; Dupré N; Miliukhina I; Timofeeva A; Emelyanov A; Pchelina S; Greenbaum L; Hassin-Baer S; Alcalay RN; Milnerwood A; Durcan TM; Gan-Or Z; Fon EA
bioRxiv; 2023 Nov; ():. PubMed ID: 38014143
[TBL] [Abstract][Full Text] [Related]
9. Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment.
Maki RA; Holzer M; Motamedchaboki K; Malle E; Masliah E; Marsche G; Reynolds WF
Free Radic Biol Med; 2019 Sep; 141():115-140. PubMed ID: 31175983
[TBL] [Abstract][Full Text] [Related]
10. Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
Xie YX; Naseri NN; Fels J; Kharel P; Na Y; Lane D; Burré J; Sharma M
Nat Commun; 2022 Aug; 13(1):4918. PubMed ID: 35995799
[TBL] [Abstract][Full Text] [Related]
11. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.
Cuddy LK; Wani WY; Morella ML; Pitcairn C; Tsutsumi K; Fredriksen K; Justman CJ; Grammatopoulos TN; Belur NR; Zunke F; Subramanian A; Affaneh A; Lansbury PT; Mazzulli JR
Neuron; 2019 Dec; 104(5):869-884.e11. PubMed ID: 31648898
[TBL] [Abstract][Full Text] [Related]
12. The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches.
Drobny A; Prieto Huarcaya S; Dobert J; Kluge A; Bunk J; Schlothauer T; Zunke F
Biochim Biophys Acta Mol Cell Res; 2022 Jul; 1869(7):119243. PubMed ID: 35217144
[TBL] [Abstract][Full Text] [Related]
13. Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
McGlinchey RP; Lee JC
Proc Natl Acad Sci U S A; 2015 Jul; 112(30):9322-7. PubMed ID: 26170293
[TBL] [Abstract][Full Text] [Related]
14. The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease.
Jimenez-Ferrer I; Bäckström F; Dueñas-Rey A; Jewett M; Boza-Serrano A; Luk KC; Deierborg T; Swanberg M
Brain Behav Immun; 2021 Jan; 91():369-382. PubMed ID: 33223048
[TBL] [Abstract][Full Text] [Related]
15. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Hu D; Sun X; Liao X; Zhang X; Zarabi S; Schimmer A; Hong Y; Ford C; Luo Y; Qi X
Acta Neuropathol; 2019 Jun; 137(6):939-960. PubMed ID: 30877431
[TBL] [Abstract][Full Text] [Related]
16. Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells.
Rostami J; Jäntti M; Cui H; Rinne MK; Kukkonen JP; Falk A; Erlandsson A; Myöhänen T
Biomed Pharmacother; 2020 Nov; 131():110788. PubMed ID: 33152946
[TBL] [Abstract][Full Text] [Related]
17. VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.
Miura E; Hasegawa T; Konno M; Suzuki M; Sugeno N; Fujikake N; Geisler S; Tabuchi M; Oshima R; Kikuchi A; Baba T; Wada K; Nagai Y; Takeda A; Aoki M
Neurobiol Dis; 2014 Nov; 71():1-13. PubMed ID: 25107340
[TBL] [Abstract][Full Text] [Related]
18. C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.
McGlinchey RP; Lacy SM; Huffer KE; Tayebi N; Sidransky E; Lee JC
J Biol Chem; 2019 Jun; 294(25):9973-9984. PubMed ID: 31092553
[TBL] [Abstract][Full Text] [Related]
19. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
Mazzulli JR; Zunke F; Tsunemi T; Toker NJ; Jeon S; Burbulla LF; Patnaik S; Sidransky E; Marugan JJ; Sue CM; Krainc D
J Neurosci; 2016 Jul; 36(29):7693-706. PubMed ID: 27445146
[TBL] [Abstract][Full Text] [Related]
20. Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.
Rodrigues PV; de Godoy JVP; Bosque BP; Amorim Neto DP; Tostes K; Palameta S; Garcia-Rosa S; Tonoli CCC; de Carvalho HF; de Castro Fonseca M
Sci Rep; 2022 Mar; 12(1):4168. PubMed ID: 35264710
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
