BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 37312859)

  • 1. Covalent
    Schwickert M; Zimmermann RA; Habeck T; Hoba SN; Nidoieva Z; Fischer TR; Stark MM; Kersten C; Lermyte F; Helm M; Schirmeister T
    ACS Med Chem Lett; 2023 Jun; 14(6):777-787. PubMed ID: 37312859
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment.
    Schwickert M; Fischer TR; Zimmermann RA; Hoba SN; Meidner JL; Weber M; Weber M; Stark MM; Koch J; Jung N; Kersten C; Windbergs M; Lyko F; Helm M; Schirmeister T
    J Med Chem; 2022 Jul; 65(14):9750-9788. PubMed ID: 35849534
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery and Computational Studies of Potent Covalent Kinase Inhibitors with α-Substituent Electrophiles Targeting Cysteine.
    Ai Y; Yang Z; Yang Z; Wan S; Huang C; Huang C; Li M; Li Z; Zhang J; Zhang T
    J Chem Inf Model; 2023 Jan; 63(2):493-506. PubMed ID: 36632804
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
    Goll MG; Kirpekar F; Maggert KA; Yoder JA; Hsieh CL; Zhang X; Golic KG; Jacobsen SE; Bestor TH
    Science; 2006 Jan; 311(5759):395-8. PubMed ID: 16424344
    [TBL] [Abstract][Full Text] [Related]  

  • 5. [Dnmt2 is the Most Evolutionary Conserved and Enigmatic Cytosine DNA Methyltransferase in Eukaryotes].
    Ashapkin VV; Kutueva LI; Vanyushin BF
    Genetika; 2016 Mar; 52(3):269-82. PubMed ID: 27281847
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An Optimized Microscale Thermophoresis Method for High-Throughput Screening of DNA Methyltransferase 2 Ligands.
    Zimmermann RA; Schwickert M; Meidner JL; Nidoieva Z; Helm M; Schirmeister T
    ACS Pharmacol Transl Sci; 2022 Nov; 5(11):1079-1085. PubMed ID: 36407957
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
    Jurkowski TP; Meusburger M; Phalke S; Helm M; Nellen W; Reuter G; Jeltsch A
    RNA; 2008 Aug; 14(8):1663-70. PubMed ID: 18567810
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.
    Lee HY; Suciu RM; Horning BD; Vinogradova EV; Ulanovskaya OA; Cravatt BF
    Bioorg Med Chem Lett; 2018 Sep; 28(16):2682-2687. PubMed ID: 29731364
    [TBL] [Abstract][Full Text] [Related]  

  • 9.
    Wen W; Cao H; Xu Y; Ren Y; Rao L; Shao X; Chen H; Wu L; Liu J; Su C; Peng C; Huang Y; Wan J
    J Med Chem; 2022 Jul; 65(13):9126-9143. PubMed ID: 35786925
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance.
    Schwartz PA; Kuzmic P; Solowiej J; Bergqvist S; Bolanos B; Almaden C; Nagata A; Ryan K; Feng J; Dalvie D; Kath JC; Xu M; Wani R; Murray BW
    Proc Natl Acad Sci U S A; 2014 Jan; 111(1):173-8. PubMed ID: 24347635
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.
    Grabrijan K; Hrast M; Proj M; Dolšak A; Zdovc I; Imre T; Petri L; Ábrányi-Balogh P; Keserű GM; Gobec S
    Eur J Med Chem; 2022 Dec; 243():114752. PubMed ID: 36126388
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lysine-Reactive
    Kawano M; Murakawa S; Higashiguchi K; Matsuda K; Tamura T; Hamachi I
    J Am Chem Soc; 2023 Dec; 145(48):26202-26212. PubMed ID: 37987622
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors.
    McAulay K; Hoyt EA; Thomas M; Schimpl M; Bodnarchuk MS; Lewis HJ; Barratt D; Bhavsar D; Robinson DM; Deery MJ; Ogg DJ; Bernardes GJL; Ward RA; Waring MJ; Kettle JG
    J Am Chem Soc; 2020 Jun; 142(23):10358-10372. PubMed ID: 32412754
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis.
    Schaefer M; Steringer JP; Lyko F
    PLoS One; 2008 Jan; 3(1):e1414. PubMed ID: 18183295
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3.
    Parenti MD; Naldi M; Manoni E; Fabini E; Cederfelt D; Talibov VO; Gressani V; Guven U; Grossi V; Fasano C; Sanese P; De Marco K; Shtil AA; Kurkin AV; Altieri A; Danielson UH; Caretti G; Simone C; Varchi G; Bartolini M; Del Rio A
    Eur J Med Chem; 2022 Dec; 243():114683. PubMed ID: 36116234
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of selective covalent cathepsin K inhibitors containing novel 4-cyanopyrimidine warhead based on quantum chemical calculations and binding mode analysis.
    Jia Y; Wang K; Wang H; Zhang B; Yang K; Zhang Z; Dong H; Wang J
    Bioorg Med Chem; 2022 Nov; 74():117053. PubMed ID: 36270112
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity.
    Buker SM; Gurard-Levin ZA; Wheeler BD; Scholle MD; Case AW; Hirsch JL; Ribich S; Copeland RA; Boriack-Sjodin PA
    SLAS Discov; 2020 Apr; 25(4):361-371. PubMed ID: 31585521
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.
    Johannsson S; Neumann P; Wulf A; Welp LM; Gerber HD; Krull M; Diederichsen U; Urlaub H; Ficner R
    Sci Rep; 2018 Jun; 8(1):8880. PubMed ID: 29892076
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.
    Tovy A; Siman Tov R; Gaentzsch R; Helm M; Ankri S
    PLoS Pathog; 2010 Feb; 6(2):e1000775. PubMed ID: 20174608
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
    Dong A; Yoder JA; Zhang X; Zhou L; Bestor TH; Cheng X
    Nucleic Acids Res; 2001 Jan; 29(2):439-48. PubMed ID: 11139614
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.