BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 37339720)

  • 1. A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461.
    Jin M; Hurley LH; Xu H
    Bioorg Med Chem Lett; 2023 Jul; 91():129384. PubMed ID: 37339720
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex).
    Xu H; Hurley LH
    Bioorg Med Chem Lett; 2022 Dec; 77():129016. PubMed ID: 36195286
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
    Xu H; Di Antonio M; McKinney S; Mathew V; Ho B; O'Neil NJ; Santos ND; Silvester J; Wei V; Garcia J; Kabeer F; Lai D; Soriano P; Banáth J; Chiu DS; Yap D; Le DD; Ye FB; Zhang A; Thu K; Soong J; Lin SC; Tsai AH; Osako T; Algara T; Saunders DN; Wong J; Xian J; Bally MB; Brenton JD; Brown GW; Shah SP; Cescon D; Mak TW; Caldas C; Stirling PC; Hieter P; Balasubramanian S; Aparicio S
    Nat Commun; 2017 Feb; 8():14432. PubMed ID: 28211448
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461.
    Masud T; Soong C; Xu H; Biele J; Bjornson S; McKinney S; Aparicio S
    Sci Rep; 2021 May; 11(1):9812. PubMed ID: 33963218
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.
    Koh GCC; Boushaki S; Zhao SJ; Pregnall AM; Sadiyah F; Badja C; Memari Y; Georgakopoulos-Soares I; Nik-Zainal S
    Nat Genet; 2024 Jan; 56(1):23-26. PubMed ID: 38036782
    [TBL] [Abstract][Full Text] [Related]  

  • 6. G-quadruplex DNA: a novel target for drug design.
    Teng FY; Jiang ZZ; Guo M; Tan XZ; Chen F; Xi XG; Xu Y
    Cell Mol Life Sci; 2021 Oct; 78(19-20):6557-6583. PubMed ID: 34459951
    [TBL] [Abstract][Full Text] [Related]  

  • 7. G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.
    McLuckie KI; Di Antonio M; Zecchini H; Xian J; Caldas C; Krippendorff BF; Tannahill D; Lowe C; Balasubramanian S
    J Am Chem Soc; 2013 Jul; 135(26):9640-3. PubMed ID: 23782415
    [TBL] [Abstract][Full Text] [Related]  

  • 8. G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells.
    Piekna-Przybylska D; Bambara RA; Maggirwar SB; Dewhurst S
    Cell Cycle; 2020 Sep; 19(18):2298-2313. PubMed ID: 32807015
    [TBL] [Abstract][Full Text] [Related]  

  • 9. DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells.
    Liu S; Wang Z; Shah SB; Chang CY; Ai M; Nguyen T; Xiang R; Wu X
    J Biol Chem; 2023 Jan; 299(1):102770. PubMed ID: 36470428
    [TBL] [Abstract][Full Text] [Related]  

  • 10. DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting.
    Chen L; Dickerhoff J; Sakai S; Yang D
    Acc Chem Res; 2022 Sep; 55(18):2628-2646. PubMed ID: 36054116
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Breast Cancer Predisposition Genes and Synthetic Lethality.
    Neiger HE; Siegler EL; Shi Y
    Int J Mol Sci; 2021 May; 22(11):. PubMed ID: 34070674
    [No Abstract]   [Full Text] [Related]  

  • 12. FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.
    Guo E; Ishii Y; Mueller J; Srivatsan A; Gahman T; Putnam CD; Wang JYJ; Kolodner RD
    Proc Natl Acad Sci U S A; 2020 Aug; 117(32):19415-19424. PubMed ID: 32719125
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.
    Musumeci D; Amato J; Zizza P; Platella C; Cosconati S; Cingolani C; Biroccio A; Novellino E; Randazzo A; Giancola C; Pagano B; Montesarchio D
    Biochim Biophys Acta Gen Subj; 2017 May; 1861(5 Pt B):1341-1352. PubMed ID: 28130159
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
    Mengwasser KE; Adeyemi RO; Leng Y; Choi MY; Clairmont C; D'Andrea AD; Elledge SJ
    Mol Cell; 2019 Mar; 73(5):885-899.e6. PubMed ID: 30686591
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours.
    Groelly FJ; Porru M; Zimmer J; Benainous H; De Visser Y; Kosova AA; Di Vito S; Serra V; Ryan A; Leonetti C; Bruna A; Biroccio A; Tarsounas M
    EMBO Mol Med; 2022 Mar; 14(3):e14501. PubMed ID: 35107878
    [TBL] [Abstract][Full Text] [Related]  

  • 16. G-quadruplex in cancer biology and drug discovery.
    Nakanishi C; Seimiya H
    Biochem Biophys Res Commun; 2020 Oct; 531(1):45-50. PubMed ID: 32312519
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Determination of the binding of natural products to the human c-myb oncogene promoter G-quadruplex DNA by capillary electrophoresis and electrospray ionization mass spectrometry].
    Wang S; Yang Y; Fan S; Li H; David DYC
    Se Pu; 2020 Sep; 38(9):1069-1077. PubMed ID: 34213273
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of a potent Guanidine derivative that selectively binds and stabilizes the human BCL-2 G-quadruplex DNA and downregulates the transcription.
    Pandya N; Rani R; Kumar V; Kumar A
    Gene; 2023 Jan; 851():146975. PubMed ID: 36261091
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction.
    Carbajosa S; Pansa MF; Paviolo NS; Castellaro AM; Andino DL; Nigra AD; García IA; Racca AC; Rodriguez-Berdini L; Angiolini V; Guantay L; Villafañez F; Federico MB; Rodríguez-Baili MC; Caputto BL; Drewes G; Madauss KP; Gloger I; Fernandez E; Gil GA; Bocco JL; Gottifredi V; Soria G
    Clin Cancer Res; 2019 Jul; 25(13):4049-4062. PubMed ID: 30890549
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Assessing G4-Binding Ligands In Vitro and in Cellulo Using Dimeric Carbocyanine Dye Displacement Assay.
    Desai N; Shah V; Datta B
    Molecules; 2021 Mar; 26(5):. PubMed ID: 33807659
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.