145 related articles for article (PubMed ID: 37349114)
1. NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction.
Mitamura R; Nakano M; Isono M; Kurosawa K; Fukami T; Nakajima M
Drug Metab Dispos; 2023 Oct; 51(10):1230-1237. PubMed ID: 37349114
[TBL] [Abstract][Full Text] [Related]
2. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.
Svecova L; Vrzal R; Burysek L; Anzenbacherova E; Cerveny L; Grim J; Trejtnar F; Kunes J; Pour M; Staud F; Anzenbacher P; Dvorak Z; Pavek P
Drug Metab Dispos; 2008 Feb; 36(2):339-48. PubMed ID: 17998298
[TBL] [Abstract][Full Text] [Related]
3. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
[TBL] [Abstract][Full Text] [Related]
4. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.
Tan H; Xu C; Zeng H; Wang Y; Li Y; Fan X; Chen P; Jiang Y; Chen X; Huang M; Bi H
J Pharmacol Sci; 2016 Feb; 130(2):66-71. PubMed ID: 26782648
[TBL] [Abstract][Full Text] [Related]
5. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.
Taneja G; Chu C; Maturu P; Moorthy B; Ghose R
Drug Metab Dispos; 2018 Apr; 46(4):397-404. PubMed ID: 29440179
[TBL] [Abstract][Full Text] [Related]
6. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
Chang HY; Chen CJ; Ma WC; Cheng WK; Lin YN; Lee YR; Chen JJ; Lim YP
Phytomedicine; 2017 Dec; 36():37-49. PubMed ID: 29157826
[TBL] [Abstract][Full Text] [Related]
7. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
El-Sankary W; Bombail V; Gibson GG; Plant N
Drug Metab Dispos; 2002 Sep; 30(9):1029-34. PubMed ID: 12167569
[TBL] [Abstract][Full Text] [Related]
8. Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.
Liu CL; Lim YP; Hu ML
Mar Drugs; 2012 Jan; 10(1):242-257. PubMed ID: 22363234
[TBL] [Abstract][Full Text] [Related]
9. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
[TBL] [Abstract][Full Text] [Related]
10. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Li T; Chiang JY
Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
[TBL] [Abstract][Full Text] [Related]
11. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Kim S; Dinchuk JE; Anthony MN; Orcutt T; Zoeckler ME; Sauer MB; Mosure KW; Vuppugalla R; Grace JE; Simmermacher J; Dulac HA; Pizzano J; Sinz M
Drug Metab Dispos; 2010 Jan; 38(1):16-24. PubMed ID: 19833845
[TBL] [Abstract][Full Text] [Related]
12. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
Kanno Y; Tanuma N; Yazawa S; Zhao S; Inaba M; Nakamura S; Nemoto K; Inouye Y
Drug Metab Dispos; 2016 Aug; 44(8):1158-63. PubMed ID: 27197997
[TBL] [Abstract][Full Text] [Related]
13. Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Zhang L; Yan J; Liu J; Meng C; Liu F; Xia C
Phytomedicine; 2022 Jul; 101():154097. PubMed ID: 35417848
[TBL] [Abstract][Full Text] [Related]
14. The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.
Lin YS; Yasuda K; Assem M; Cline C; Barber J; Li CW; Kholodovych V; Ai N; Chen JD; Welsh WJ; Ekins S; Schuetz EG
Drug Metab Dispos; 2009 Jun; 37(6):1295-304. PubMed ID: 19251824
[TBL] [Abstract][Full Text] [Related]
15. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
Ma X; Cheung C; Krausz KW; Shah YM; Wang T; Idle JR; Gonzalez FJ
Drug Metab Dispos; 2008 Dec; 36(12):2506-12. PubMed ID: 18799805
[TBL] [Abstract][Full Text] [Related]
16. Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
Luckert C; Ehlers A; Buhrke T; Seidel A; Lampen A; Hessel S
Toxicol Lett; 2013 Oct; 222(2):180-8. PubMed ID: 23845848
[TBL] [Abstract][Full Text] [Related]
17. Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells.
Wang X; Yu Y; Wang P; Yang K; Wang Y; Yan L; Zhong XB; Zhang L
Drug Metab Dispos; 2022 May; 50(5):704-715. PubMed ID: 34949673
[TBL] [Abstract][Full Text] [Related]
18. The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.
Doricakova A; Novotna A; Vrzal R; Pavek P; Dvorak Z
Arch Toxicol; 2013 Feb; 87(2):291-301. PubMed ID: 22976785
[TBL] [Abstract][Full Text] [Related]
19. Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
Hu Q; Yao N; Wu J; Liu M; Liu F; Zhang H; Xiong Y; Xia C
Biochem Pharmacol; 2019 Jan; 159():32-39. PubMed ID: 30414935
[TBL] [Abstract][Full Text] [Related]
20. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.
Krausova L; Stejskalova L; Wang H; Vrzal R; Dvorak Z; Mani S; Pavek P
Biochem Pharmacol; 2011 Dec; 82(11):1771-80. PubMed ID: 21920351
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
