These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
6. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Jaleel M; Nichols RJ; Deak M; Campbell DG; Gillardon F; Knebel A; Alessi DR Biochem J; 2007 Jul; 405(2):307-17. PubMed ID: 17447891 [TBL] [Abstract][Full Text] [Related]
7. Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues. Iannotta L; Biosa A; Kluss JH; Tombesi G; Kaganovich A; Cogo S; Plotegher N; Civiero L; Lobbestael E; Baekelandt V; Cookson MR; Greggio E Cells; 2020 Oct; 9(11):. PubMed ID: 33105882 [TBL] [Abstract][Full Text] [Related]
8. Wauters F; Cornelissen T; Imberechts D; Martin S; Koentjoro B; Sue C; Vangheluwe P; Vandenberghe W Autophagy; 2020 Feb; 16(2):203-222. PubMed ID: 30945962 [TBL] [Abstract][Full Text] [Related]
9. 14-3-3theta protects against neurotoxicity in a cellular Parkinson's disease model through inhibition of the apoptotic factor Bax. Slone SR; Lesort M; Yacoubian TA PLoS One; 2011; 6(7):e21720. PubMed ID: 21799745 [TBL] [Abstract][Full Text] [Related]
10. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Ito G; Katsemonova K; Tonelli F; Lis P; Baptista MA; Shpiro N; Duddy G; Wilson S; Ho PW; Ho SL; Reith AD; Alessi DR Biochem J; 2016 Sep; 473(17):2671-85. PubMed ID: 27474410 [TBL] [Abstract][Full Text] [Related]
11. Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations. Sheng Z; Zhang S; Bustos D; Kleinheinz T; Le Pichon CE; Dominguez SL; Solanoy HO; Drummond J; Zhang X; Ding X; Cai F; Song Q; Li X; Yue Z; van der Brug MP; Burdick DJ; Gunzner-Toste J; Chen H; Liu X; Estrada AA; Sweeney ZK; Scearce-Levie K; Moffat JG; Kirkpatrick DS; Zhu H Sci Transl Med; 2012 Dec; 4(164):164ra161. PubMed ID: 23241745 [TBL] [Abstract][Full Text] [Related]
13. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Nichols RJ; Dzamko N; Morrice NA; Campbell DG; Deak M; Ordureau A; Macartney T; Tong Y; Shen J; Prescott AR; Alessi DR Biochem J; 2010 Sep; 430(3):393-404. PubMed ID: 20642453 [TBL] [Abstract][Full Text] [Related]
14. The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation. Cogo S; Ho FY; Tosoni E; Tomkins JE; Tessari I; Iannotta L; Montine TJ; Manzoni C; Lewis PA; Bubacco L; Chartier Harlin MC; Taymans JM; Kortholt A; Nichols J; Cendron L; Civiero L; Greggio E Brain Res; 2022 Mar; 1778():147781. PubMed ID: 35016853 [TBL] [Abstract][Full Text] [Related]
15. LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner. Kania E; Long JS; McEwan DG; Welkenhuyzen K; La Rovere R; Luyten T; Halpin J; Lobbestael E; Baekelandt V; Bultynck G; Ryan KM; Parys JB Cell Death Dis; 2023 Jul; 14(7):436. PubMed ID: 37454104 [TBL] [Abstract][Full Text] [Related]
16. Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. Li X; Wang QJ; Pan N; Lee S; Zhao Y; Chait BT; Yue Z PLoS One; 2011 Mar; 6(3):e17153. PubMed ID: 21390248 [TBL] [Abstract][Full Text] [Related]
17. LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. Taymans JM; Vancraenenbroeck R; Ollikainen P; Beilina A; Lobbestael E; De Maeyer M; Baekelandt V; Cookson MR PLoS One; 2011; 6(8):e23207. PubMed ID: 21858031 [TBL] [Abstract][Full Text] [Related]
18. Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain. Singh V; Menard MA; Serrano GE; Beach TG; Zhao HT; Riley-DiPaolo A; Subrahmanian N; LaVoie MJ; Volpicelli-Daley LA Acta Neuropathol Commun; 2023 Dec; 11(1):201. PubMed ID: 38110990 [TBL] [Abstract][Full Text] [Related]
19. Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity. Fernández B; Chittoor-Vinod VG; Kluss JH; Kelly K; Bryant N; Nguyen APT; Bukhari SA; Smith N; Lara Ordóñez AJ; Fdez E; Chartier-Harlin MC; Montine TJ; Wilson MA; Moore DJ; West AB; Cookson MR; Nichols RJ; Hilfiker S J Parkinsons Dis; 2022; 12(5):1423-1447. PubMed ID: 35599495 [TBL] [Abstract][Full Text] [Related]
20. Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. Karayel Ö; Tonelli F; Virreira Winter S; Geyer PE; Fan Y; Sammler EM; Alessi DR; Steger M; Mann M Mol Cell Proteomics; 2020 Sep; 19(9):1546-1560. PubMed ID: 32601174 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]