127 related articles for article (PubMed ID: 37421557)
1. HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics.
Sheik Ismail Z; Worth R; Mosebi S; Sayed Y
Protein J; 2023 Oct; 42(5):490-501. PubMed ID: 37421557
[TBL] [Abstract][Full Text] [Related]
2. Double trouble? Gag in conjunction with double insert in HIV protease contributes to reduced DRV susceptibility.
Williams A; Basson A; Achilonu I; Dirr HW; Morris L; Sayed Y
Biochem J; 2019 Jan; 476(2):375-384. PubMed ID: 30573649
[TBL] [Abstract][Full Text] [Related]
3. Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease.
Zondagh J; Balakrishnan V; Achilonu I; Dirr HW; Sayed Y
J Mol Graph Model; 2018 Jun; 82():1-11. PubMed ID: 29625416
[TBL] [Abstract][Full Text] [Related]
4. Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
Liu Z; Huang X; Hu L; Pham L; Poole KM; Tang Y; Mahon BP; Tang W; Li K; Goldfarb NE; Dunn BM; McKenna R; Fanucci GE
J Biol Chem; 2016 Oct; 291(43):22741-22756. PubMed ID: 27576689
[TBL] [Abstract][Full Text] [Related]
5. An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant.
Sanusi ZK; Govender T; Maguire GEM; Maseko SB; Lin J; Kruger HG; Honarparvar B
J Comput Aided Mol Des; 2018 Mar; 32(3):459-471. PubMed ID: 29397520
[TBL] [Abstract][Full Text] [Related]
6. Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.
Naicker P; Achilonu I; Fanucchi S; Fernandes M; Ibrahim MA; Dirr HW; Soliman ME; Sayed Y
J Biomol Struct Dyn; 2013 Dec; 31(12):1370-80. PubMed ID: 23140382
[TBL] [Abstract][Full Text] [Related]
7. Cantilever-centric mechanism of cooperative non-active site mutations in HIV protease: Implications for flap dynamics.
Sherry D; Worth R; Ismail ZS; Sayed Y
J Mol Graph Model; 2021 Jul; 106():107931. PubMed ID: 34030114
[TBL] [Abstract][Full Text] [Related]
8. Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir.
Venkatachalam S; Murlidharan N; Krishnan SR; Ramakrishnan C; Setshedi M; Pandian R; Barh D; Tiwari S; Azevedo V; Sayed Y; Gromiha MM
Genes (Basel); 2023 Feb; 14(2):. PubMed ID: 36833460
[TBL] [Abstract][Full Text] [Related]
9. Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.
Burnaman SH; Kneller DW; Wang YF; Kovalevsky A; Weber IT
J Mol Graph Model; 2021 Nov; 108():108005. PubMed ID: 34419931
[TBL] [Abstract][Full Text] [Related]
10. Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.
Agniswamy J; Louis JM; Roche J; Harrison RW; Weber IT
PLoS One; 2016; 11(12):e0168616. PubMed ID: 27992544
[TBL] [Abstract][Full Text] [Related]
11. Drug susceptibility and replication capacity of a rare HIV-1 subtype C protease hinge region variant.
Zondagh J; Basson AE; Achilonu I; Morris L; Dirr HW; Sayed Y
Antivir Ther; 2019; 24(5):333-342. PubMed ID: 30958309
[TBL] [Abstract][Full Text] [Related]
12. Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
Gupta A; Jamal S; Goyal S; Jain R; Wahi D; Grover A
BMC Bioinformatics; 2015; 16 Suppl 19(Suppl 19):S10. PubMed ID: 26695135
[TBL] [Abstract][Full Text] [Related]
13. I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions.
Maseko SB; Padayachee E; Govender T; Sayed Y; Kruger G; Maguire GEM; Lin J
Biol Chem; 2017 Sep; 398(10):1109-1117. PubMed ID: 28525359
[TBL] [Abstract][Full Text] [Related]
14. Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.
Maseko SB; Natarajan S; Sharma V; Bhattacharyya N; Govender T; Sayed Y; Maguire GE; Lin J; Kruger HG
Protein Expr Purif; 2016 Jun; 122():90-6. PubMed ID: 26917227
[TBL] [Abstract][Full Text] [Related]
15. Exploring the drug resistance mechanism of active site, non-active site mutations and their cooperative effects in CRF01_AE HIV-1 protease: molecular dynamics simulations and free energy calculations.
C S V; Tamizhselvi R; Munusami P
J Biomol Struct Dyn; 2019 Jul; 37(10):2608-2626. PubMed ID: 30051758
[TBL] [Abstract][Full Text] [Related]
16. Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.
Chetty S; Bhakat S; Martin AJ; Soliman ME
J Biomol Struct Dyn; 2016; 34(1):135-51. PubMed ID: 25671669
[TBL] [Abstract][Full Text] [Related]
17. Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
Kneller DW; Agniswamy J; Harrison RW; Weber IT
FEBS J; 2020 Aug; 287(15):3235-3254. PubMed ID: 31920003
[TBL] [Abstract][Full Text] [Related]
18. Elucidating a relationship between conformational sampling and drug resistance in HIV-1 protease.
de Vera IM; Smith AN; Dancel MC; Huang X; Dunn BM; Fanucci GE
Biochemistry; 2013 May; 52(19):3278-88. PubMed ID: 23566104
[TBL] [Abstract][Full Text] [Related]
19. Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease.
Maseko S; Padayachee E; Maphumulo S; Govender T; Sayed Y; Maguire G; Lin J; Naicker T; Baijnath S; Gerhardus KH
J Enzyme Inhib Med Chem; 2019 Dec; 34(1):1451-1456. PubMed ID: 31409143
[TBL] [Abstract][Full Text] [Related]
20. Flap-site Fragment Restores Back Wild-type Behaviour in Resistant Form of HIV Protease.
Luchi A; Angelina E; Bogado L; Forli S; Olson A; Peruchena N
Mol Inform; 2018 Dec; 37(12):e1800053. PubMed ID: 30051611
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]