BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 37421557)

  • 1. HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics.
    Sheik Ismail Z; Worth R; Mosebi S; Sayed Y
    Protein J; 2023 Oct; 42(5):490-501. PubMed ID: 37421557
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Double trouble? Gag in conjunction with double insert in HIV protease contributes to reduced DRV susceptibility.
    Williams A; Basson A; Achilonu I; Dirr HW; Morris L; Sayed Y
    Biochem J; 2019 Jan; 476(2):375-384. PubMed ID: 30573649
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease.
    Zondagh J; Balakrishnan V; Achilonu I; Dirr HW; Sayed Y
    J Mol Graph Model; 2018 Jun; 82():1-11. PubMed ID: 29625416
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
    Liu Z; Huang X; Hu L; Pham L; Poole KM; Tang Y; Mahon BP; Tang W; Li K; Goldfarb NE; Dunn BM; McKenna R; Fanucci GE
    J Biol Chem; 2016 Oct; 291(43):22741-22756. PubMed ID: 27576689
    [TBL] [Abstract][Full Text] [Related]  

  • 5. An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant.
    Sanusi ZK; Govender T; Maguire GEM; Maseko SB; Lin J; Kruger HG; Honarparvar B
    J Comput Aided Mol Des; 2018 Mar; 32(3):459-471. PubMed ID: 29397520
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.
    Naicker P; Achilonu I; Fanucchi S; Fernandes M; Ibrahim MA; Dirr HW; Soliman ME; Sayed Y
    J Biomol Struct Dyn; 2013 Dec; 31(12):1370-80. PubMed ID: 23140382
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cantilever-centric mechanism of cooperative non-active site mutations in HIV protease: Implications for flap dynamics.
    Sherry D; Worth R; Ismail ZS; Sayed Y
    J Mol Graph Model; 2021 Jul; 106():107931. PubMed ID: 34030114
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir.
    Venkatachalam S; Murlidharan N; Krishnan SR; Ramakrishnan C; Setshedi M; Pandian R; Barh D; Tiwari S; Azevedo V; Sayed Y; Gromiha MM
    Genes (Basel); 2023 Feb; 14(2):. PubMed ID: 36833460
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.
    Burnaman SH; Kneller DW; Wang YF; Kovalevsky A; Weber IT
    J Mol Graph Model; 2021 Nov; 108():108005. PubMed ID: 34419931
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.
    Agniswamy J; Louis JM; Roche J; Harrison RW; Weber IT
    PLoS One; 2016; 11(12):e0168616. PubMed ID: 27992544
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Drug susceptibility and replication capacity of a rare HIV-1 subtype C protease hinge region variant.
    Zondagh J; Basson AE; Achilonu I; Morris L; Dirr HW; Sayed Y
    Antivir Ther; 2019; 24(5):333-342. PubMed ID: 30958309
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
    Gupta A; Jamal S; Goyal S; Jain R; Wahi D; Grover A
    BMC Bioinformatics; 2015; 16 Suppl 19(Suppl 19):S10. PubMed ID: 26695135
    [TBL] [Abstract][Full Text] [Related]  

  • 13. I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions.
    Maseko SB; Padayachee E; Govender T; Sayed Y; Kruger G; Maguire GEM; Lin J
    Biol Chem; 2017 Sep; 398(10):1109-1117. PubMed ID: 28525359
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.
    Maseko SB; Natarajan S; Sharma V; Bhattacharyya N; Govender T; Sayed Y; Maguire GE; Lin J; Kruger HG
    Protein Expr Purif; 2016 Jun; 122():90-6. PubMed ID: 26917227
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Exploring the drug resistance mechanism of active site, non-active site mutations and their cooperative effects in CRF01_AE HIV-1 protease: molecular dynamics simulations and free energy calculations.
    C S V; Tamizhselvi R; Munusami P
    J Biomol Struct Dyn; 2019 Jul; 37(10):2608-2626. PubMed ID: 30051758
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.
    Chetty S; Bhakat S; Martin AJ; Soliman ME
    J Biomol Struct Dyn; 2016; 34(1):135-51. PubMed ID: 25671669
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
    Kneller DW; Agniswamy J; Harrison RW; Weber IT
    FEBS J; 2020 Aug; 287(15):3235-3254. PubMed ID: 31920003
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Elucidating a relationship between conformational sampling and drug resistance in HIV-1 protease.
    de Vera IM; Smith AN; Dancel MC; Huang X; Dunn BM; Fanucci GE
    Biochemistry; 2013 May; 52(19):3278-88. PubMed ID: 23566104
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease.
    Maseko S; Padayachee E; Maphumulo S; Govender T; Sayed Y; Maguire G; Lin J; Naicker T; Baijnath S; Gerhardus KH
    J Enzyme Inhib Med Chem; 2019 Dec; 34(1):1451-1456. PubMed ID: 31409143
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Flap-site Fragment Restores Back Wild-type Behaviour in Resistant Form of HIV Protease.
    Luchi A; Angelina E; Bogado L; Forli S; Olson A; Peruchena N
    Mol Inform; 2018 Dec; 37(12):e1800053. PubMed ID: 30051611
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.