BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 37423123)

  • 1. Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M
    Jörg M; van der Westhuizen ET; Lu Y; Christopher Choy KH; Shackleford DM; Khajehali E; Tobin AB; Thal DM; Capuano B; Christopoulos A; Valant C; Scammells PJ
    Eur J Med Chem; 2023 Oct; 258():115588. PubMed ID: 37423123
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Probing the binding site of novel selective positive allosteric modulators at the M
    Khajehali E; Valant C; Jörg M; Tobin AB; Conn PJ; Lindsley CW; Sexton PM; Scammells PJ; Christopoulos A
    Biochem Pharmacol; 2018 Aug; 154():243-254. PubMed ID: 29777683
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M
    van der Westhuizen ET; Spathis A; Khajehali E; Jörg M; Mistry SN; Capuano B; Tobin AB; Sexton PM; Scammells PJ; Valant C; Christopoulos A
    Mol Pharmacol; 2018 Jul; 94(1):770-783. PubMed ID: 29691279
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biased Profile of Xanomeline at the Recombinant Human M
    McDonald JK; van der Westhuizen ET; Pham V; Thompson G; Felder CC; Paul SM; Thal DM; Christopoulos A; Valant C
    ACS Chem Neurosci; 2022 Apr; 13(8):1206-1218. PubMed ID: 35380782
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
    Jakubík J; Bacáková L; El-Fakahany EE; Tucek S
    Mol Pharmacol; 1997 Jul; 52(1):172-9. PubMed ID: 9224827
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders.
    Teal LB; Gould RW; Felts AS; Jones CK
    Adv Pharmacol; 2019; 86():153-196. PubMed ID: 31378251
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M
    Schubert JW; Harrison ST; Mulhearn J; Gomez R; Tynebor R; Jones K; Bunda J; Hanney B; Wai JM; Cox C; McCauley JA; Sanders JM; Magliaro B; O'Brien J; Pajkovic N; Huszar Agrapides SL; Taylor A; Gotter A; Smith SM; Uslaner J; Browne S; Risso S; Egbertson M
    ChemMedChem; 2019 May; 14(9):943-951. PubMed ID: 30920765
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.
    Huynh T; Valant C; Crosby IT; Sexton PM; Christopoulos A; Capuano B
    J Med Chem; 2013 Oct; 56(20):8196-200. PubMed ID: 24074052
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-Activity Relationships of Pan-Gα
    Berizzi AE; Bender AM; Lindsley CW; Conn PJ; Sexton PM; Langmead CJ; Christopoulos A
    ACS Chem Neurosci; 2018 Jul; 9(7):1818-1828. PubMed ID: 29683647
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and structure-activity relationships study of positive allosteric modulators of the M
    Tanaka H; Negoro K; Koike T; Tsukamoto I; Yokoyama K; Maeda J; Inagaki Y; Shimoshige Y; Ino K; Ishizu K; Takahashi T
    Bioorg Med Chem; 2020 Jul; 28(13):115531. PubMed ID: 32386953
    [TBL] [Abstract][Full Text] [Related]  

  • 11. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
    Nawaratne V; Leach K; Suratman N; Loiacono RE; Felder CC; Armbruster BN; Roth BL; Sexton PM; Christopoulos A
    Mol Pharmacol; 2008 Oct; 74(4):1119-31. PubMed ID: 18628403
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004.
    Huynh T; Valant C; Crosby IT; Sexton PM; Christopoulos A; Capuano B
    ACS Chem Neurosci; 2015 Jun; 6(6):838-44. PubMed ID: 25857219
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.
    Leach K; Loiacono RE; Felder CC; McKinzie DL; Mogg A; Shaw DB; Sexton PM; Christopoulos A
    Neuropsychopharmacology; 2010 Mar; 35(4):855-69. PubMed ID: 19940843
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.
    Nawaratne V; Leach K; Felder CC; Sexton PM; Christopoulos A
    J Biol Chem; 2010 Jun; 285(25):19012-21. PubMed ID: 20406819
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor.
    Suratman S; Leach K; Sexton P; Felder C; Loiacono R; Christopoulos A
    Br J Pharmacol; 2011 Apr; 162(7):1659-70. PubMed ID: 21198541
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bitopic Binding Mode of an M
    Bradley SJ; Molloy C; Bundgaard C; Mogg AJ; Thompson KJ; Dwomoh L; Sanger HE; Crabtree MD; Brooke SM; Sexton PM; Felder CC; Christopoulos A; Broad LM; Tobin AB; Langmead CJ
    Mol Pharmacol; 2018 Jun; 93(6):645-656. PubMed ID: 29695609
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies.
    Birdsall NJ; Farries T; Gharagozloo P; Kobayashi S; Lazareno S; Sugimoto M
    Mol Pharmacol; 1999 Apr; 55(4):778-86. PubMed ID: 10101037
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Allosteric modulators of M
    Widman CJ; Ventresca S; Dietrich J; Elmslie G; Smith H; Kaup G; Wesley A; Doenecke M; Williams FE; Schiefer IT; Ellis J; Messer WS
    Sci Rep; 2024 Jun; 14(1):14901. PubMed ID: 38942828
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.
    Smith DL; Davoren JE; Edgerton JR; Lazzaro JT; Lee CW; Neal S; Zhang L; Grimwood S
    Mol Pharmacol; 2016 Sep; 90(3):177-87. PubMed ID: 27382013
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
    Vuckovic Z; Wang J; Pham V; Mobbs JI; Belousoff MJ; Bhattarai A; Burger WAC; Thompson G; Yeasmin M; Nawaratne V; Leach K; van der Westhuizen ET; Khajehali E; Liang YL; Glukhova A; Wootten D; Lindsley CW; Tobin A; Sexton P; Danev R; Valant C; Miao Y; Christopoulos A; Thal DM
    Elife; 2023 May; 12():. PubMed ID: 37248726
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.